Results 41 to 50 of about 446,619 (318)

Endogenous Inhibition and the Neural Basis of “Free Won't” [PDF]

open access: yesThe Journal of Neuroscience, 2007
Every day we perform thousands of actions and, although we might pay little attention to them, we take for granted that they are mostly generated by our will. In other words, we seem to believe in the existence of a “free will” as an inner causal agent of our behavior.
openaire   +5 more sources

Closing in on the constitution of consciousness

open access: yesFrontiers in Psychology, 2014
The science of consciousness is a nascent and thriving field of research that is founded on identifying the minimally sufficient neural correlates of consciousness.
Steven M. Miller
doaj   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

open access: yesFEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source

Characterizing the Neural Correlates of Response Inhibition and Error Processing in Children With Symptoms of Irritability and/or Attention-Deficit/Hyperactivity Disorder in the ABCD Study®

open access: yesFrontiers in Psychiatry, 2022
Attention-deficit/hyperactivity disorder (ADHD), characterized by symptoms of inattention and/or hyperactivity and impulsivity, is a neurodevelopmental disorder associated with executive dysfunctions, including response inhibition and error processing ...
Ka Shu Lee   +9 more
doaj   +1 more source

Refining the NaV1.7 pharmacophore of a class of venom‐derived peptide inhibitors via a combination of in silico screening and rational engineering

open access: yesFEBS Letters, EarlyView.
Venom peptides have shown promise in treating pain. Our study uses computer screening to identify a peptide that targets a sodium channel (NaV1.7) linked to chronic pain. We produced the peptide in the laboratory and refined its design, advancing the search for innovative pain therapies.
Gagan Sharma   +8 more
wiley   +1 more source

Dissociation between cortical and spinal excitability of the antagonist muscle during combined motor imagery and action observation

open access: yesScientific Reports, 2019
Inhibitory neural control of antagonist muscle is one of the fundamental neural mechanism of coordinated human limb movement. Previous studies have revealed that motor execution (ME) and motor imagery (MI) share many common neural substrates; however ...
Toshiyuki Aoyama   +3 more
doaj   +1 more source

Anxiety-Like Behavioural Inhibition Is Normative under Environmental Threat-Reward Correlations.

open access: yesPLoS Computational Biology, 2015
Behavioural inhibition is a key anxiety-like behaviour in rodents and humans, distinct from avoidance of danger, and reduced by anxiolytic drugs. In some situations, it is not clear how behavioural inhibition minimises harm or maximises benefit for the ...
Dominik R Bach
doaj   +1 more source

Neural correlates of central inhibition during physical fatigue. [PDF]

open access: yesPLoS ONE, 2013
Central inhibition plays a pivotal role in determining physical performance during physical fatigue. Classical conditioning of central inhibition is believed to be associated with the pathophysiology of chronic fatigue.
Masaaki Tanaka   +2 more
doaj   +1 more source

Normalized neural representations of natural odors [PDF]

open access: yes, 2016
The olfactory system removes correlations in natural odors using a network of inhibitory neurons in the olfactory bulb. It has been proposed that this network integrates the response from all olfactory receptors and inhibits them equally. However, how such global inhibition influences the neural representations of odors is unclear.
arxiv   +1 more source

Neural Activity of Heterogeneous Inhibitory Spiking Networks with Delay [PDF]

open access: yesPhys. Rev. E 99, 052412 (2019), 2019
We study a network of spiking neurons with heterogeneous excitabilities connected via inhibitory delayed pulses. For globally coupled systems the increase of the inhibitory coupling reduces the number of firing neurons by following a Winner Takes All mechanism.
arxiv   +1 more source

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