Results 61 to 70 of about 446,619 (318)
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
Neural Correlates of the Preserved Inhibition of Return in Schizophrenia
PLOS ONE, 2015 Inhibition of return (IOR) is an attentional mechanism that previously has been reported to be either intact or blunted in subjects with schizophrenia (SCZ). In the present study, we explored the neural mechanism of IOR in SCZ by comparing the target-locked N1 and P1 activity evoked by valid-cued trials with that evoked by invalid-cued trials.
Yan Li +11 more
openaire +5 more sources
Changes in BOLD variability are linked to the development of variable response inhibition
NeuroImage, 2021 Research on the development of response inhibition in humans has focused almost exclusively on average stopping performance. The development of intra-individual variability in stopping performance and its underlying neural circuitry has remained largely ...
Abigail Thompson +2 more
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Critical excitation-inhibition balance in dense neural networks [PDF]
Phys. Rev. E 100, 010301 (2019), 2019 The "edge of chaos" phase transition in artificial neural networks is of renewed interest in light of recent evidence for criticality in brain dynamics. Statistical mechanics traditionally studied this transition with connectivity $k$ as the control parameter and an exactly balanced excitation-inhibition ratio.
arxiv +1 more source
FEBS Letters, EarlyView.B cells sense external mechanical forces and convert them into biochemical signals through mechanotransduction. Understanding how malignant B cells respond to physical stimuli represents a groundbreaking area of research. This review examines the key mechano‐related molecules and pathways in B lymphocytes, highlights the most relevant techniques to ...
Marta Sampietro +2 more
wiley +1 more source
Disinhibition of somatostatin interneurons confers resilience to stress in male but not female mice
Neurobiology of Stress, 2020 Chronic stress represents a vulnerability factor for anxiety and depressive disorders and has been widely used to model aspects of these disorders in rodents.
Sarah J. Jefferson +5 more
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Molecular Oncology, EarlyView.Presurgery 72‐h fasting in GB patients leads to adaptations of plasma lipids and polar metabolites. Fasting reduces lysophosphatidylcholines and increases free fatty acids, shifts triglycerides toward long‐chain TGs and increases branched‐chain amino acids, alpha aminobutyric acid, and uric acid.
Iris Divé +7 more
wiley +1 more source
Neural differentiation is increased by GSK-3β inhibition and decreased by tankyrase inhibition in human neural precursor cells [PDF]
, 2019 AbstractGlycogen synthase kinase-3β (GSK-3β) and tankyrase-1/2 (TANK) are two enzymes known to play multiple roles in cell biology, including regulation of proliferation, differentiation and metabolism. Both of them act on the canonical Wnt/β-Catenin pathway, but are also involved in many other independent intracellular mechanisms.
Telias, Michael, Ben-Yosef, Dalit
openaire +2 more sources
Transcriptome‐wide analysis of circRNA and RBP profiles and their molecular relevance for GBM
Molecular Oncology, EarlyView.CircRNAs are differentially expressed in glioblastoma primary tumors and might serve as therapeutic targets and diagnostic markers. The investigation of circRNA and RNA‐binding proteins (RBPs) interactions shows that distinct RBPs play a role in circRNA biogenesis and function.
Julia Latowska‐Łysiak +14 more
wiley +1 more source
Cell Reports, 2023 Summary: Alpha oscillations are a distinctive feature of the awake resting state of the human brain. However, their functional role in resting-state neuronal dynamics remains poorly understood.
Fabrizio Lombardi +7 more
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