Results 91 to 100 of about 5,830,276 (292)

Arginine methylation as a regulatory ratchet in cancer: From substrate selection to malignant‐state stabilization

Molecular Oncology, EarlyView.
Arginine methylation can be viewed as a persistence‐prone post‐translational modification regulated by a network of PRMTs. Competitive and compensatory interactions among PRMTs can redistribute methylation across substrate pools shaped by sequence, structural, spatial, and environmental layers, reinforcing RNA‐processing, chromatin, and signaling ...
So Hyun Kwon, Ji Min Lee
wiley   +1 more source

Active noise control algorithm based on a neural network and nonlinear input-output system identification model

Archives of Acoustics, 2013
The development of digital signal processors and the increase in their computing capabilities bring opportunities to employ algorithms with multiple variable parameters in active noise control systems.
Tomasz KRUKOWICZ
doaj  

Characterising motor and cognitive contributions of cortical beta oscillations and their modulation with rTMS

NeuroImage
Cortical beta oscillations are central to motor control. These rhythms are modulated during movement preparation and execution and are also sensitive to cognitive factors such as uncertainty and attention.
Shenghong He, Juan Francisco Martin-Rodriguez, Alek Pogosyan, Eduardo M. Moraud, Huiling Tan   +4 more
doaj   +1 more source

Towards Clinical Diagnosis: Automated Stroke Lesion Segmentation on Multi-Spectral MR Image Using Convolutional Neural Network

IEEE Access, 2018
The patient with ischemic stroke can benefit most from the earliest possible definitive diagnosis. While a quantitative evaluation of the stroke lesions on the magnetic resonance images (MRIs) is effective in clinical diagnosis, manually segmenting the ...
Zhiyang Liu, Chen Cao, Shuxue Ding, Zhiang Liu, Tong Han, Sheng Liu   +5 more
doaj   +1 more source

Directed evolution of enzymes at the crossroads of tradition and innovation

FEBS Open Bio, EarlyView.
An iterative cycle of data‐driven enzyme optimization comprising four stages: genetic diversification of a template enzyme, expression of protein variants, high‐throughput evaluation, and machine‐learning‐guided redesign of the next variant library.
Maria Tomkova, Andrej Mirossay, Erik Sedlak   +2 more
wiley   +1 more source

Postsynaptic density protein 95 (PSD-95) is transported by KIF5 to dendritic regions

Molecular Brain, 2019
Postsynaptic density protein 95 (PSD-95) is a pivotal postsynaptic scaffolding protein in excitatory neurons. Although the transport and regulation of PSD-95 in synaptic regions is well understood, dendritic transport of PSD-95 before synaptic ...
Ki-Seo Yoo, Kina Lee, Jun-Young Oh, Hyoeun Lee, Hyungju Park, Young Seok Park, Hyong Kyu Kim   +6 more
doaj   +1 more source

General fuzzy min-max neural network for clustering and classification [PDF]

, 2000
This paper describes a general fuzzy min-max (GFMM) neural network which is a generalization and extension of the fuzzy min-max clustering and classification algorithms of Simpson (1992, 1993).
Gabrys, Bogdan, Bargiela, Andrzej
core   +1 more source

Guiding AlphaFold to predict how Munc13‐1 opens Syntaxin‐1

FEBS Open Bio, EarlyView.
The syntaxin‐1 Habc‐domain (orange), linker (pink) and SNARE motif (yellow) form a closed conformation that binds to Munc18‐1 (violet) and is opened by the Munc13‐1 MUN domain (cyan) to form the SNARE complex that triggers neurotransmitter release.
Madhurima Chattopadhyay, Junjie Xu, Josep Rizo   +2 more
wiley   +1 more source

Hyperactive ice‐binding proteins stabilize cell membranes and improve resistance to dehydration stress in Caenorhabditis elegans

FEBS Open Bio, EarlyView.
TisIBP8, a fungal‐derived hyperactive ice‐binding protein, helps Caenorhabditis elegans survive dehydration. It localizes near cell membranes, reduces cell damage, and helps maintain membrane structure during drying. These results suggest that ice‐binding proteins can protect cells from dehydration stress as well as freezing stress.
Daiki Shimose, Kotaro Ozaki, Ryohei Kuriyama, Yuka Ikemoto, Kazuhiro Mio, Yuji C. Sasaki, Tatsuya Arai, Sakae Tsuda, Yoichi Shinkai, Masahiro Kuramochi   +9 more
wiley   +1 more source

Loss of AMBRA1 activates MAPK and angiogenesis signaling pathways in melanoma cells

FEBS Open Bio, EarlyView.
Loss of AMBRA1 in melanoma cells activates multiple oncogenic pathways associated with tumor progression. Transcriptomic and protein network analyses revealed that AMBRA1 depletion enhances MAPK/ERK signaling, angiogenesis, TGF‐β/EMT signaling, and Wnt/axon guidance pathways.
Milad Ibrahim, Marco Corazzari, Iman Osman, Jane Armstrong, Noel Carter   +4 more
wiley   +1 more source