Results 101 to 110 of about 5,830,276 (292)

Anterior cingulate cortex and its input to the basolateral amygdala control innate fear response

Nature Communications, 2018
Brain circuits that control innate fear response are essential for an animal’s survival. Here, the authors report how the anterior cingulate cortex and its projection to amygdala control the innate fear response in mice.
Jinho Jhang, Hyoeun Lee, Min Soo Kang, Han-Sol Lee, Hyungju Park, Jin-Hee Han   +5 more
doaj   +1 more source

From energy provision to protein synthesis: Tunnelling nanotubes as mediators of intercellular metabolic cooperation in cancer

FEBS Open Bio, EarlyView.
The cytoskeleton‐mediated transport of mitochondria via tunnelling nanotubes restores respiration, increases ATP production, rescues cells from apoptosis, activates the AKT/mTOR signalling pathway, promotes cell migration and invasiveness, contributes to cancer progression and treatment resistance.
Stanislava Martínková, Jan Trnka
wiley   +1 more source

Neural networks for inference, inference for neural networks

, 2018
Bayesian statistics is a powerful framework for modeling the world and reasoning over uncertainty. It provides a principled method for representing our prior knowledge, and updating that knowledge in the light of new information. Traditional Bayesian statistics, however, has been limited to simple models.
openaire   +3 more sources

Neural DAEs: Constrained Neural Networks

SIAM Journal on Scientific Computing
This article investigates the effect of explicitly adding auxiliary algebraic trajectory information to neural networks for dynamical systems. We draw inspiration from the field of differential-algebraic equations and differential equations on manifolds and implement related methods in residual neural networks, despite some fundamental scenario ...
Tue Boesen, Eldad Haber, Uri M. Ascher
openaire   +5 more sources

SORN : a self-organizing recurrent neural network [PDF]

, 2009
Understanding the dynamics of recurrent neural networks is crucial for explaining how the brain processes information. In the neocortex, a range of different plasticity mechanisms are shaping recurrent networks into effective information processing ...
Pipa, Gordon, Andreea Lazar, Triesch, Jochen, Lazar, Andreea, Gordon Pipa, Jochen Triesch   +5 more
core   +1 more source

Treatment with KCL‐286, a first‐in‐class retinoic acid receptor‐β (RARβ) agonist, ameliorates neuronal DNA damage and inflammation in a mouse model of Alzheimer's disease

FEBS Open Bio, EarlyView.
Repair of neuronal DNA damage in Alzheimer's disease by KCL‐286. (A) Amyloid‐β oligomers and plaques impair neuronal DNA repair pathways, leading to DNA double‐strand breaks and glial activation. (B) KCL‐286 activates RARβ/RXR signalling via retinoic acid response elements (RAREs), associated with increased BRCA1 expression, enhanced DNA repair and ...
Natasha Hill, Hassan Yousef Othman AlMuallim, Elouisa Maddock, Carl Hobbs, Earl Clarke, Maria B. Goncalves, Jonathan P. T. Corcoran   +6 more
wiley   +1 more source

Single-nucleus transcriptomics reveals a distinct microglial state and increased MSR1-mediated phagocytosis as common features across dementia subtypes

Genome Medicine
Background Alzheimer’s disease (AD), dementia with Lewy bodies (DLB), and Parkinson’s disease dementia (PDD) collectively represent the majority of dementia cases worldwide.
Sook-Yoong Chia, Mengwei Li, Zhihong Li, Haitao Tu, Jolene Wei Ling Lee, Lifeng Qiu, Jingjing Ling, Richard Reynolds, Salvatore Albani, Eng-King Tan, Adeline Su Lyn Ng, Jinmiao Chen, Li Zeng   +12 more
doaj   +1 more source

Neural network ensembles

IEEE Transactions on Pattern Analysis and Machine Intelligence, 1990
Several means for improving the performance and training of neural networks for classification are proposed. Crossvalidation is used as a tool for optimizing network parameters and architecture. It is shown that the remaining residual generalization error can be reduced by invoking ensembles of similar networks. >
Lars Kai Hansen, Peter Salamon
openaire   +3 more sources

NEW TECHNIQUES APPLIED IN ECONOMICS. ARTIFICIAL NEURAL NETWORK [PDF]

The present paper has the objective to inform the public regarding the use of new techniques for the modeling, simulate and forecast of system from different field of activity.
Constantin Ilie, Margareta Udrescu
core  

Accurate and noninvasive prostate cancer detection using plasma‐derived extracellular vesicle RNA

FEBS Open Bio, EarlyView.
Plasma extracellular vesicles were captured with WGA‐conjugated magnetic beads and profiled for RNA biomarkers. A three‐RNA panel (NM_024955, NR_047469, and NR_002564) distinguished prostate cancer from healthy controls and benign prostatic hyperplasia, supporting a simple, noninvasive approach to improve prostate cancer detection.
Hanping Wei, Haoran Wu, Wei Feng
wiley   +1 more source