Results 101 to 110 of about 29,945 (263)

A regulatory transcriptional loop controls proliferation and differentiation in Drosophila neural stem cells [PDF]

, 2014
Neurogenesis is initiated by a set of basic Helix-Loop-Helix (bHLH) transcription factors that specify neural progenitors and allow them to generate neurons in multiple rounds of asymmetric cell division.
Heinrich Reichert, Reichert, Heinrich, Juergen A. Knoblich (481769), Yasugi, Tetsuo, Anja Fischer (509977), Anja Fischer, Tetsuo Yasugi (560564), Heinrich Reichert (42730), Juergen A. Knoblich, Fischer, Anja, Jiang, Yanrui, Knoblich, Juergen A., Tetsuo Yasugi, Yanrui Jiang, Yanrui Jiang (560565), Juergen A Knoblich   +15 more
core   +1 more source

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

Molecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau, Lilian G. Zhai, Ryunosuke Hoshi, Zackary Rousseau, Abraam Zakhary, Yin Fang Wu, Rola M. Saleeb, Heyu Ni, Kelsie L. Thu   +8 more
wiley   +1 more source

SnapShot: Neural Pathways that Control Feeding

Cell Metabolism, 2014
This SnapShot provides an overview of brain systems such as the hypothalamus and brainstem that sense and integrate nutritional signals controlling eating.
Myers, Martin G., Olson, David P.
openaire   +2 more sources

Model selection and adaptation for biochemical pathways

, 2010
In bioinformatics, biochemical signal pathways can be modeled by many differential equations. It is still an open problem how to fit the huge amount of parameters of the equations to the available data.
Brause, Rüdiger W.
core  

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Posteriorizing factor Gbx2 is a direct target of Wnt signalling during neural crest induction

, 2015
Wnt signalling is required for neural crest induction; however the direct targets of the Wnt pathway during neural crest induction remain unknown. I show here that the homeobox gene Gbx2 is essential in this process and is directly activated by Wnt/β ...
Li, B
core  

Nondirected axonal growth on basal lamina from avian embryonic neural retina [PDF]

, 1987
The vitreous surface of the embryonic avian retinal neuroepithelium was isolated by mechanical disruption of the retina mounted between 2 adhesive substrata.
Kröger, Stephan, Kröger, S. ; https://orcid.org/, Reckhaus, W., W Halfter, W Reckhaus, S Kroger, Halfter, W.   +6 more
core   +1 more source

Harmony in the brain: A narrative review on the shared neural substrates of emotion regulation and creativity

Brain Organoid and Systems Neuroscience Journal
The contribution of creativity in overall well-being through regulating emotions has sparkled research interest in employing artistic interventions recently for the improvement of mental health.
A.I. Ladas, T. Gravalas, C. Katsoridou, C.A. Frantzidis   +3 more
doaj   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

Parallel Excitatory and Inhibitory Neural Circuit Pathways Underlie Reward-Based Phasic Neural Responses

Complexity, 2018
Phasic activity of dopaminergic (DA) neurons in the ventral tegmental area or substantia nigra compacta (VTA/SNc) has been suggested to encode reward-prediction error signal for reinforcement learning. Recent studies have shown that the lateral habenula (
Huanyuan Zhou, KongFatt Wong-Lin, Da-Hui Wang   +2 more
doaj   +1 more source