Results 61 to 70 of about 6,298,151 (304)

Human iPSC‐Derived Tissue‐Engineered Nigrostriatal Pathway for Chronic Restoration of Dopaminergic Axon Tracts in a Rat Parkinson's Model

Advanced Healthcare Materials, EarlyView.
Inspired by conventional cell therapy and emerging bioengineering approaches, the tissue‐engineered nigrostriatal pathway (TE‐NSP) has an anatomically‐inspired design comprising a population of human dopaminergic neurons with unidirectional, long‐projecting axon tracts.
Wisberty J. Gordián‐Vélez, Dimple Chouhan, Kevin D. Browne, James Lim, Saarang P. Karandikar, Rodrigo A. España, John E. Duda, H. Isaac Chen, D. Kacy Cullen   +8 more
wiley   +1 more source

Forcing neural progenitor cells to cycle is insufficient to alter cell-fate decision and timing of neuronal differentiation in the spinal cord

Neural Development, 2008
Background During the development of the nervous system, neural progenitor cells can either stay in the pool of proliferating undifferentiated cells or exit the cell cycle and differentiate. Two main factors will determine the fate of a neural progenitor
Trousse Françoise, Bel-Vialar Sophie, Lobjois Valérie, Pituello Fabienne   +3 more
doaj   +1 more source

Anti‐Inflammatory and Neuroactive Effects of Polymer‐Coated Iron Oxide Nanoparticles Functionalized With Interleukin 4 for Spinal Cord Injury

Advanced Healthcare Materials, EarlyView.
Polymer‐coated IONPs functionalized with IL‐4 display respective neuroactive and anti‐inflammatory actions on neural progenitor cells and macrophages/microglia in vitro. When examined chronically in a rat experimental model of spinal cord injury, rGO scaffolds carrying these nanosystems adequately integrate into the lesion, significantly reduce ...
Julia Martínez‐Ramírez, Paloma Lozano‐Picazo, María de Lamo‐Atencia, Andrea Ferreras, Esther Benayas‐Martín, Elena Fernández‐López, Marina Sánchez‐Petidier, Verónica Barranco‐Maresca, Víctor Caz, Anne des Rieux, Juliana M. Rosa, María del Puerto Morales, María C. Serrano   +12 more
wiley   +1 more source

Proliferation zones in the axolotl brain and regeneration of the telencephalon

Neural Development, 2013
Background Although the brains of lower vertebrates are known to exhibit somewhat limited regeneration after incisional or stab wounds, the Urodele brain exhibits extensive regeneration after massive tissue removal.
Maden Malcolm, Manwell Laurie A, Ormerod Brandi K   +2 more
doaj   +1 more source

Cul4B regulates neural progenitor cell growth [PDF]

BMC Neuroscience, 2012
Abstract Background Cullin ubiquitin ligases are activated via the covalent modification of Cullins by the small ubiquitin-like protein nedd8 in a process called neddylation. Genetic mutations of cullin-4b (cul4b) cause a prevalent type of X-linked intellectual disability (XLID) in males, but the physiological ...
Liu Helio C, Enikolopov Grigori, Chen Yuzhi   +2 more
openaire   +3 more sources

Characterisation of neural progenitors from the adult retina and ciliary epithelium [PDF]

, 2009
The mammalian central neural retina (CNR) lacks the capability to regenerate, a phenomenon retained by lower vertebrates. However, retinal stem cells have been isolated from the ciliary epithelium of the mammalian retina.
Kokkinopoulos, I.
core  

The Endocannabinoid System Promotes Astroglial Differentiation by Acting on Neural Progenitor Cells [PDF]

, 2006
Endocannabinoids exert an important neuromodulatory role via presynaptic cannabinoid CB1 receptors and may also participate in the control of neural cell death and survival.
Monory, K, Stella, Nephi, Palazuelos, J, Lutz, B, Guzmán Pastor, Manuel, Marsicano, Giovanni, Galve Roperh, Ismael, Galve-Roperh, I, Stella, N, Palazuelos Diego, Javier, Guzman, M, Aguado, T, Cravatt, B, Monory, Krisztina, Kokaia, Zaal,, Marsicano, G, Lutz, Beat, Kokaia, Zaal, Cravatt, Benjamin, Aguado Sánchez, Tania, Lund University.   +20 more
core   +1 more source

Bone Organoids Across the Development‐to‐Remodeling Continuum: From Tissue Formation to Functional Competence and Translation

Advanced Healthcare Materials, EarlyView.
Mineralization alone does not establish a mature bone organoid. This Review integrates biological foundations, materials design, adaptive remodeling, and translational validation through the development‐to‐remodeling continuum (DRC). By separating biological functions from the evidence supporting them, the framework exposes critical gaps in current ...
Xijie Tang, Haijia Xu, Xiangzhong Liu, Yi Yang, Zhanghua Li   +4 more
wiley   +1 more source

Establishment of human iPSC-based models for the study and targeting of glioma initiating cells

Nature Communications, 2016
Glioma can originate from the transformation of neural progenitor cells into glioma initiating cells. Here, the authors demonstrate the use of induced pluripotent stem cells as a suitable model for generating neural progenitor cells, which can be ...
Ignacio Sancho-Martinez, Emmanuel Nivet, Yun Xia, Tomoaki Hishida, Aitor Aguirre, Alejandro Ocampo, Li Ma, Robert Morey, Marie N. Krause, Andreas Zembrzycki, Olaf Ansorge, Eric Vazquez-Ferrer, Ilir Dubova, Pradeep Reddy, David Lam, Yuriko Hishida, Min-Zu Wu, Concepcion Rodriguez Esteban, Dennis O’Leary, Geoffrey M. Wahl, Inder M. Verma, Louise C. Laurent, Juan Carlos Izpisua Belmonte   +22 more
doaj   +1 more source

Live-cell Migration Assays to Study Motility of Neural and Glial (Oligodendrocyte) Progenitor Cells

Bio-Protocol, 2019
Cell motility has been extensively studied in in vitro models using fibroblasts and keratocytes, but the cell type-specific mechanisms underlying migration of lineage- or disease-specific cells, such as neural and glial progenitor cells, remain an active
Chu-Yen Chen, Fu-Sheng Chou, Pei-Shan Wang   +2 more
doaj   +1 more source