Results 51 to 60 of about 6,298,151 (304)

Chronobiology of Cancer: How Aging Fuels Oncogenesis at the Molecular Level

Aging and Cancer, EarlyView.
This graphical abstract illustrates the key biological pathways linking aging with cancer development and progression. In the upper left, cumulative exposure to ultraviolet radiation, toxins, and reactive oxygen species (ROS) causes DNA damage and genomic instability, whereas age‐related decline in repair mechanisms, such as ATM/ATR, BER, and NER ...
Anu Singh, Aroonima Misra, Sufian Zaheer
wiley   +1 more source

Involvement of p38 in Age-Related Decline in Adult Neurogenesis via Modulation of Wnt Signaling

Stem Cell Reports, 2019
Summary: Neurogenesis in specific brain regions in adult mammals decreases with age. Progressive reduction in the proliferation of neural stem and progenitor cells (NS/PCs) is a primary cause of this age-associated decline.
Yoshitaka Kase, Kinya Otsu, Takuya Shimazaki, Hideyuki Okano   +3 more
doaj   +1 more source

Drosophila Neural Stem Cells in Brain Development and Tumor Formation [PDF]

, 2014
Neuroblasts, the neural stem cells in Drosophila, generate the complex neural structure of the central nervous system. Significant progress has been made in understanding the mechanisms regulating the self-renewal, proliferation, and differentiation in ...
Reichert, Heinrich, Jiang, Yanrui, Jiang Y, Reichert H   +3 more
core   +1 more source

Region Specific miRNA–mRNA Networks in Gray and White Matter Lesions of Progressive Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Multiple sclerosis (MS) is a neurodegenerative demyelinating disease of the central nervous system. This study aimed to identify micro‐RNA (miRNA)–mRNA regulatory networks underlying region‐specific molecular mechanisms in white matter and gray matter lesions in progressive MS.
Adya Sapra, Nagendra K. Rai, Timothy D. Niepokny, Haley Courtney, Ajai Tripathi, Ranjan Dutta   +5 more
wiley   +1 more source

Relationships between genome-wide R-loop distribution and classes of recurrent DNA breaks in neural stem/progenitor cells

Scientific Reports, 2022
Recent studies revealed classes of recurrent DNA double-strand breaks (DSBs) in neural stem/progenitor cells, including transcription-associated, promoter-proximal breaks and recurrent DSB clusters in late-replicating, long neural genes that may give ...
Supawat Thongthip, Annika Carlson, Magdalena P. Crossley, Bjoern Schwer   +3 more
doaj   +1 more source

An Epigenetic Fate Converter Based on Nuclei‐Targeting Lipid Nanoparticles Drives Neuronal Programming of Stem Cells for Spinal Cord Repair

Advanced Functional Materials, EarlyView.
Schematic illustration of LNP‐MPG nuclei‐targeting delivery of HMW‐FGF2 promoting histone acetylation to regulate the fate of DPSCs and treat spinal cord injury. LNPs components include pHMW‐FGF2 plasmid, DSPC, Dlin‐MC3‐DMA, cholesterol, and PEG2000, and are modified with MPG to form HMW‐FGF2@LNP‐MPG (HLM). HLM nuclei‐targets DPSCs to deliver HMW‐FGF2,
Heng Zhou, Qiang Qin, Xiqin Li, Hanyu Ding, Chun Xu, Yan He, Qingsong Ye   +6 more
wiley   +1 more source

Human neural progenitor cells retain viability, phenotype, proliferation, and lineage differentiation when labeled with a novel iron oxide nanoparticle, Molday ION Rhodamine B

International Journal of Nanomedicine, 2013
Wei-Bin Shen,1,2 Celine Plachez,2,3 Amanda Chan,4 Deborah Yarnell,1 Adam C Puche,3 Paul S Fishman,1,5 Paul Yarowsky1,21Research Service, VA Maryland Health Care System, Baltimore, MD, USA; 2Department of Pharmacology, University of Maryland School of ...
Shen WB, Plachez C, Chan A, Yarnell D, Puche AC, Fishman PS, Yarowsky P   +6 more
doaj  

Adult hippocampal neurogenesis inversely correlates with microglia in conditions of voluntary running and aging.

Frontiers in Neuroscience, 2013
Adult hippocampal neurogenesis results in the formation of new neurons and is a process of brain plasticity involved in learning and memory. The proliferation of adult neural stem or progenitor cells is regulated by several extrinsic factors such as ...
Elias Georges Gebara, Sebastien eSultan, Jacqueline eKocher-Braissant, Nicolas eToni   +3 more
doaj   +1 more source

Advancing Human Skin Equivalents: The Crucial Role of Neurovascular Integration

Advanced Healthcare Materials, EarlyView.
This review discusses the importance of integrating vascular and peripheral nerve systems into human skin equivalents (HSEs) to better recapitulate native skin physiology. Recent advances in vascularized, innervated, and neurovascularized HSEs are highlighted, together with emerging bioengineering strategies, current challenges, and future ...
Hao Wu, Lorenzo Moroni, Nicolas Lebonvallet, Vincent Flacher, Paul Wieringa   +4 more
wiley   +1 more source

MYC Expression Promotes the Proliferation of Neural Progenitor Cells in Culture and In Vivo

Neoplasia: An International Journal for Oncology Research, 2002
Primitive neuroectodermal tumors. (20PNETs) are pediatric brain tumors that result from defects in signaling molecules governing the growth and differentiation of neural progenitor cells.
Dan Fults, Carolyn Pedone, Chengkai Dai, Eric C. Holland   +3 more
doaj   +1 more source