Results 11 to 20 of about 417,177 (325)
Bone Marrow Transplantation, 2003 The adult vertebrate central nervous system (CNS) consists of four major differentiated cell types: neurons, astrocytes, oligodendrocytes and ependymal cells. Historically, there has been a disagreement on how these differentiated cell types are generated in the CNS. Progress remains hindered by the complexity of cell structure in this system, the lack
Rossella Galli +3 more
+9 more sources
The Journal of Pathology, 2002 AbstractNeural stem cells (NSCs) have the ability to self‐renew, and are capable of differentiating into neurones, astrocytes and oligodendrocytes. Such cells have been isolated from the developing brain and more recently from the adult central nervous system. This review aims to provide an overview of the current research in this evolving area.
Tanja Zigova +2 more
+7 more sources
Flexibility of Neural Stem Cells [PDF]
Frontiers in Physiology, 2011 Embryonic cortical neural stem cells are self-renewing progenitors that can differentiate into neurons and glia. We generated neurospheres from the developing cerebral cortex using a mouse genetic model that allows for lineage selection and found that the self-renewing neural stem cells are restricted to Sox2 expressing cells.
Remboutsika, Eumorphia +7 more
openaire +5 more sources
Neural Stem Cells and Stroke [PDF]
Cell Transplantation, 2013 Acute ischemic stroke causes a disturbance of neuronal circuitry and disruption of the blood–brain barrier that can lead to functional disabilities. At present, thrombolytic therapy inducing recanalization of the occluded vessels in the cerebral infarcted area is a commonly used therapeutic strategy.
Chen Huan Lin +3 more
openaire +3 more sources
Induced Stem Cells as a Novel Multiple Sclerosis Therapy. [PDF]
, 2016 Stem cell replacement is providing hope for many degenerative diseases that lack effective therapeutic methods including multiple sclerosis (MS), an inflammatory demyelinating disease of the central nervous system. Transplantation of neural stem cells or
Guan, Yang-Tai +3 more
core +2 more sources
Journal of Investigative Dermatology Symposium Proceedings, 1997 This article is concerned with the idea that neural precursor cells in vertebrates can self-renew and give rise to all cell types within the nervous system. Supportive evidence for this notion of neural stem cells comes from clonal analyses undertaken both in vivo and in vitro. Neural stem cells also give rise to other cells in the body, including skin
Gordon J.f. Brooker +4 more
openaire +3 more sources
Proliferation versus Differentiation: Redefining Retinoic Acids Role. [PDF]
, 2018 Retinoic acid is commonly used in culture to differentiate stem cells into neurons and has established neural differentiation functions in vivo in developing and adult organisms. In this issue of Stem Cell Reports, Mishra et al.
Mosher, Kira, SCHAFFER, David
core +1 more source
Hyaluronan, neural stem cells and tissue reconstruction after acute ischemic stroke. [PDF]
, 2013 Focal stroke is a disabling disease with lifelong sensory, motor and cognitive impairments. Given the paucity of effective clinical treatments, basic scientists are developing novel options for protection of the affected brain and regeneration of lost ...
Carmichael, S Thomas, Moshayedi, Pouria
core +1 more source
, 2008 Neural stem cells (NSCs) are the self-renewing, multipotent cells that generate neurons, astrocytes, and oligodendrocytes in the nervous system. In the fetus, NSCs participate to the development of the nervous system. Stem cells are present in many tissues of adult mammals where they contribute to cellular homeostasis and regeneration after injury. The
Richard L. Sidman +6 more
+6 more sources
NPTX1 Regulates Neural Lineage Specification from Human Pluripotent Stem Cells
Cell Reports, 2014 Neural induction is the first fundamental step in nervous system formation. During development, a tightly regulated niche modulates transient extracellular signals to influence neural lineage commitment.
Nathan C. Boles +9 more
doaj +1 more source