Results 41 to 50 of about 1,045,843 (356)

Human Neural Stem Cell Extracellular Vesicles Improve Tissue and Functional Recovery in the Murine Thromboembolic Stroke Model

Translational Stroke Research, 2017
Over 700 drugs have failed in stroke clinical trials, an unprecedented rate thought to be attributed in part to limited and isolated testing often solely in “young” rodent models and focusing on a single secondary injury mechanism.
Robin L. Webb, Erin E Kaiser, S. Scoville, Tyler A. Thompson, Sumbul Fatima, C. Pandya, Karishma Sriram, R. Swetenburg, K. Vaibhav, A. Arbab, B. Baban, K. Dhandapani, D. Hess, M. Hoda, S. Stice   +14 more
semanticscholar   +1 more source

Human organoids in basic research and clinical applications

Signal Transduction and Targeted Therapy, 2022
Organoids are three-dimensional (3D) miniature structures cultured in vitro produced from either human pluripotent stem cells (hPSCs) or adult stem cells (AdSCs) derived from healthy individuals or patients that recapitulate the cellular heterogeneity ...
Xiao-Yan Tang, Shanshan Wu, Da Wang, Chu Chu, Yuan Hong, Mengdan Tao, Hao Hu, Min Xu, Xing Guo, Yan Liu   +9 more
doaj   +1 more source

Generation of an iPSC line (CRICKi001-A) from an individual with a germline SMARCA4 missense mutation and autism spectrum disorder

Stem Cell Research, 2021
Germline missense mutations in the BAF swi/snf chromatin remodeling subunit SMARCA4 are associated with neurodevelopmental disorders, including Coffin Siris Syndrome (CSS). Here, we generated an induced pluripotent stem cell line from a male patient with
Liani G. Devito, Lyn Healy, Shehla Mohammed, Francois Guillemot, Cristina Dias   +4 more
doaj   +1 more source

Lessons Learned from Pioneering Neural Stem Cell Studies

Stem Cell Reports, 2017
As stem cell products are increasingly entering early stage clinical trials, we are learning from experience about how cell products may be best assessed for safety and efficacy.
Sally Temple, Lorenz Studer
doaj   +1 more source

Lysophosphatidic Acid Receptor 1 Specifically Labels Seizure-Induced Hippocampal Reactive Neural Stem Cells and Regulates Their Division

Frontiers in Neuroscience, 2020
A population of neural stem cells (NSCs) dwelling in the dentate gyrus (DG) is able to generate neurons throughout adult life in the hippocampus of most mammals. These NSCs generate also astrocytes naturally and are capable of generating oligodendrocytes
Roberto Valcárcel-Martín, Roberto Valcárcel-Martín, Soraya Martín-Suárez, Teresa Muro-García, Teresa Muro-García, Oier Pastor-Alonso, Oier Pastor-Alonso, Fernando Rodríguez de Fonseca, Guillermo Estivil-Torrús, Juan Manuel Encinas, Juan Manuel Encinas, Juan Manuel Encinas   +11 more
doaj   +1 more source

Optimized protocol for analysis of neural stem proliferation in human-pluripotent-stem-cell-derived cerebral organoids

STAR Protocols, 2023
Summary: Cerebral organoids represent an optimal experimental system for studying human cortical development, evolution, physiology, function, and disease mechanisms.
Xiao-Yan Tang, Da Wang, Xin-Yue Zhang, Min Xu, Yan Liu   +4 more
doaj   +1 more source

Exogenous neural stem cell transplantation for cerebral ischemia

Neural Regeneration Research, 2019
Cerebral ischemic injury is the main manifestation of stroke, and its incidence in stroke patients is 70–80%. Although ischemic stroke can be treated with tissue-type plasminogen activator, its time window of effectiveness is narrow.
Ling-Yi Liao, B. Lau, D. Sánchez-Vidaña, Q. Gao   +3 more
semanticscholar   +1 more source

Shared and Divergent Epigenetic Mechanisms in Cachexia and Sarcopenia

Cells, 2022
Significant loss of muscle mass may occur in cachexia and sarcopenia, which are major causes of mortality and disability. Cachexia represents a complex multi-organ syndrome associated with cancer and chronic diseases.
Laura Yedigaryan, Martina Gatti, Vittoria Marini, Tullia Maraldi, Maurilio Sampaolesi   +4 more
doaj   +1 more source

Elevated FOXG1 and SOX2 in glioblastoma enforces neural stem cell identity through transcriptional control of cell cycle and epigenetic regulators

Genes & Development, 2017
Bulstrode et al. show that increased expression of FOXG1 and SOX2 restricts astrocyte differentiation and can trigger dedifferentiation to a proliferative neural stem cell state.
H. Bulstrode, E. Johnstone, M. Marques-Torrejon, Kirsty M. Ferguson, R. Bressan, Carla Blin, Vivien Grant, Sabine Gogolok, E. Gangoso, Sladjana Gagrica, Christine Ender, V. Fotaki, D. Sproul, Paul Bertone, S. Pollard   +14 more
semanticscholar   +1 more source

The cytoskeletal control of B cell receptor and integrin signaling in normal B cells and chronic lymphocytic leukemia

FEBS Letters, EarlyView.
In lymphoid organs, antigen recognition and B cell receptor signaling rely on integrins and the cytoskeleton. Integrins act as mechanoreceptors, couple B cell receptor activation to cytoskeletal remodeling, and support immune synapse formation as well as antigen extraction.
Abhishek Pethe, Tanja Nicole Hartmann
wiley   +1 more source