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Therapeutic Plasticity of Neural Stem Cells [PDF]

Frontiers in Neurology, 2020
Neural stem cells (NSCs) have garnered significant scientific and commercial interest in the last 15 years. Given their plasticity, defined as the ability to develop into different phenotypes inside and outside of the nervous system, with a capacity of almost unlimited self-renewal, of releasing trophic and immunomodulatory factors, and of exploiting ...
Linda Ottoboni, Beatrice von Wunster, Gianvito Martino, Gianvito Martino   +3 more
openaire   +5 more sources

Dopamine transporter neuroimaging accurately assesses the maturation of dopamine neurons in a preclinical model of Parkinson’s disease

Stem Cell Research & Therapy, 2020
Background Significant developments in stem cell therapy for Parkinson’s disease (PD) have already been achieved; however, methods for reliable assessment of dopamine neuron maturation in vivo are lacking.
Julian L. Goggi, Lifeng Qiu, Mei Chih Liao, Shivashankar Khanapur, Lingfan Jiang, Ramasamy Boominathan, Siddesh V. Hartimath, Peter Cheng, Fui Fong Yong, Vanessa Soh, Xiaozhou Deng, Youshan Melissa Lin, Anna Haslop, Peng Wen Tan, Xiaoxia Zeng, Jolene W. L. Lee, Zhiwei Zhang, Pragalath Sadasivam, Eng King Tan, Sajinder K. Luthra, William D. Shingleton, Steve K. W. Oh, Li Zeng, Edward G. Robins   +23 more
doaj   +1 more source

Human organoids in basic research and clinical applications

Signal Transduction and Targeted Therapy, 2022
Organoids are three-dimensional (3D) miniature structures cultured in vitro produced from either human pluripotent stem cells (hPSCs) or adult stem cells (AdSCs) derived from healthy individuals or patients that recapitulate the cellular heterogeneity ...
Xiao-Yan Tang, Shanshan Wu, Da Wang, Chu Chu, Yuan Hong, Mengdan Tao, Hao Hu, Min Xu, Xing Guo, Yan Liu   +9 more
doaj   +1 more source

Generation of an iPSC line (CRICKi001-A) from an individual with a germline SMARCA4 missense mutation and autism spectrum disorder

Stem Cell Research, 2021
Germline missense mutations in the BAF swi/snf chromatin remodeling subunit SMARCA4 are associated with neurodevelopmental disorders, including Coffin Siris Syndrome (CSS). Here, we generated an induced pluripotent stem cell line from a male patient with
Liani G. Devito, Lyn Healy, Shehla Mohammed, Francois Guillemot, Cristina Dias   +4 more
doaj   +1 more source

Lessons Learned from Pioneering Neural Stem Cell Studies

Stem Cell Reports, 2017
As stem cell products are increasingly entering early stage clinical trials, we are learning from experience about how cell products may be best assessed for safety and efficacy.
Sally Temple, Lorenz Studer
doaj   +1 more source

Lysophosphatidic Acid Receptor 1 Specifically Labels Seizure-Induced Hippocampal Reactive Neural Stem Cells and Regulates Their Division

Frontiers in Neuroscience, 2020
A population of neural stem cells (NSCs) dwelling in the dentate gyrus (DG) is able to generate neurons throughout adult life in the hippocampus of most mammals. These NSCs generate also astrocytes naturally and are capable of generating oligodendrocytes
Roberto Valcárcel-Martín, Roberto Valcárcel-Martín, Soraya Martín-Suárez, Teresa Muro-García, Teresa Muro-García, Oier Pastor-Alonso, Oier Pastor-Alonso, Fernando Rodríguez de Fonseca, Guillermo Estivil-Torrús, Juan Manuel Encinas, Juan Manuel Encinas, Juan Manuel Encinas   +11 more
doaj   +1 more source

Optimized protocol for analysis of neural stem proliferation in human-pluripotent-stem-cell-derived cerebral organoids

STAR Protocols, 2023
Summary: Cerebral organoids represent an optimal experimental system for studying human cortical development, evolution, physiology, function, and disease mechanisms.
Xiao-Yan Tang, Da Wang, Xin-Yue Zhang, Min Xu, Yan Liu   +4 more
doaj   +1 more source

Identification of a neural crest stem cell niche by Spatial Genomic Analysis [PDF]

, 2017
The neural crest is an embryonic population of multipotent stem cells that form numerous defining features of vertebrates. Due to lack of reliable techniques to perform transcriptional profiling in intact tissues, it remains controversial whether the ...
Bronner, Marianne E., Cai, Long, Kerosuo, Laura, Lignell, Antti, Streichan, Sebastian J.   +4 more
core   +4 more sources

Shared and Divergent Epigenetic Mechanisms in Cachexia and Sarcopenia

Cells, 2022
Significant loss of muscle mass may occur in cachexia and sarcopenia, which are major causes of mortality and disability. Cachexia represents a complex multi-organ syndrome associated with cancer and chronic diseases.
Laura Yedigaryan, Martina Gatti, Vittoria Marini, Tullia Maraldi, Maurilio Sampaolesi   +4 more
doaj   +1 more source

Making tau amyloid models in vitro: a crucial and underestimated challenge

FEBS Letters, EarlyView.
This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley   +1 more source