Results 71 to 80 of about 1,438,323 (398)
F1000Research, 2014 Rationale: Choroidal neovascular (CNV) lesions in younger patients are often accompanied by the appearance of a surrounding ring of pigment that is associated with disease regression or slowed disease progression.
Jeffrey Stern +3 more
doaj +1 more source
Role of SDF1/CXCR4 Interaction in Experimental Hemiplegic Models with Neural Cell Transplantation [PDF]
, 2012 Much attention has been focused on neural cell transplantation because of its promising clinical applications. We have reported that embryonic stem (ES) cell derived neural stem/progenitor cell transplantation significantly improved motor functions in a ...
Amoureux +76 more
core +4 more sources
eLife, 2018 Human GABAergic interneurons (GIN) are implicated in normal brain function and in numerous mental disorders. However, the generation of functional human GIN subtypes from human pluripotent stem cells (hPSCs) has not been established.
Fang Yuan +11 more
doaj +1 more source
Novel Advancements in Three-Dimensional Neural Tissue Engineering and Regenerative Medicine [PDF]
Neural Regen. Res. 2015;10(3):352-4, 2015 Neurological diseases and injuries present some of the greatest challenges in modern medicine, often causing irreversible and lifelong burdens in the people whom they afflict. These diagnoses have devastating consequences on millions of people each year, and yet there are currently no therapies or interventions that can repair the structure of neural ...
arxiv +1 more source
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
Stem Cells and Development, 2018 Maternal diabetes induces neural tube defects by suppressing neurogenesis in the developing neuroepithelium. Our recent study further revealed that high glucose inhibited embryonic stem cell differentiation into neural lineage cells.
Xi Chen +5 more
semanticscholar +1 more source
Recognition and reconstruction of cell differentiation patterns with deep learning [PDF]
arXiv, 2022 Cell lineage decisions occur in three-dimensional spatial patterns that are difficult to identify by eye. There is an ongoing effort to replicate such patterns using mathematical modeling. One approach uses long ranging cell-cell communication to replicate common spatial arrangements like checkerboard and engulfing patterns.
arxiv
Multi-Compartmental Biomaterial Scaffolds for Patterning Neural Tissue Organoids in Models of Neurodevelopment and Tissue Regeneration [PDF]
J. Tissue Engineering 2016; 7:1-8, 2016 Biomaterials are becoming an essential tool in the study and application of stem cell research. Various types of biomaterials enable three-dimensional (3D) culture of stem cells, and, more recently, also enable high-resolution patterning and organization of multicellular architectures.
arxiv +1 more source
Designing signaling environments to steer transcriptional diversity in neural progenitor cell populations [PDF]
, 2019 Stem cell populations within developing embryos are diverse, composed of many different subpopulations of cells with varying developmental potential. The structure of stem cell populations in cell culture remains poorly understood and presents a barrier ...
Chen, Sisi +4 more
core
TRIM32-dependent transcription in adult neural progenitor cells regulates neuronal differentiation [PDF]
, 2013 In the adult mammalian brain, neural stem cells in the subventricular zone continuously generate new neurons for the olfactory bulb. Cell fate commitment in these adult neural stem cells is regulated by cell fate-determining proteins.
Bahnassawy, Lamiaa +7 more
core +1 more source