Results 81 to 90 of about 448,417 (306)

A novel, long-lived, and highly engraftable immunodeficient mouse model of mucopolysaccharidosis type I

Molecular Therapy: Methods & Clinical Development, 2015
Mucopolysaccharidosis type I (MPS I) is an inherited α-L-iduronidase (IDUA, I) deficiency in which glycosaminoglycan (GAG) accumulation causes progressive multisystem organ dysfunction, neurological impairment, and death.
Daniel C Mendez, Alexander E Stover, Anthony D Rangel, David J Brick, Hubert E Nethercott, Marissa A Torres, Omar Khalid, Andrew MS Wong, Jonathan D Cooper, James V Jester, Edwin S Monuki, Cian McGuire, Steven Q Le, Shih-hsin Kan, Patricia I Dickson, Philip H Schwartz   +15 more
doaj   +1 more source

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

FEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source

Exploring the Functional Heterogeneity of Directly Reprogrammed Neural Stem Cell-Derived Neurons via Single-Cell RNA Sequencing [PDF]

, 2023
Yoo Sung Kim, NaRi Seo, Jihye Kim, Soyeong Kang, Ji Won Park, Ki Dae Park, Hyang‐Ae Lee, Misun Park   +7 more
openalex   +1 more source

Machine Learning and Medical Data: Predicting ICU Mortality and Re-admission Risks

Journal of Advanced Research in Natural and Applied Sciences
Intensive care units (ICUs) are divisions where critically ill patients are treated by medical experts. The unmet and vital need for automated clinical decision-making mechanisms is critical to maneuvering the large influx of patients.
Ulya Bayram, Runia Roy
doaj   +1 more source

First steps to define murine amniotic fluid stem cell microenvironment [PDF]

, 2016
Stem cell niche refers to the microenvironment where stem cells reside in living organisms. Several elements define the niche and regulate stem cell characteristics, such as stromal support cells, gap junctions, soluble factors, extracellular matrix ...
Bertin, Enrica, Bonaldo, Paolo, Braghetta, Paola, DE COPPI, Paolo, Dedja, Arben, Dona', Silvia, Franzin, Chiara, Piccoli, Martina, Pozzobon, Michela, Schiavi, Francesca, Spiro, Giovanna, Taschin, E.   +11 more
core   +3 more sources

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

Quantified F-Actin Morphology Is Predictive of Phagocytic Capacity of Stem Cell-Derived Retinal Pigment Epithelium

Stem Cell Reports, 2018
Summary: With stem cell-derived retinal pigment epithelial (RPE) replacement therapies in clinical testing, establishing potency of RPE prior to transplantation is imperative. Phagocytosis of photoreceptor outer segment fragments (POS) is a key indicator
Claudia Müller, Carol Charniga, Sally Temple, Silvia C. Finnemann   +3 more
doaj   +1 more source

Stem cell sources and characterization in the development of cell-based products for treating retinal disease: An NEI Town Hall report

Stem Cell Research & Therapy, 2023
National Eye Institute recently issued a new Strategic Plan outlining priority research areas for the next 5 years. Starting cell source for deriving stem cell lines is as an area with gaps and opportunities for making progress in regenerative medicine ...
Ashley M. Fortress, Kiyoharu J. Miyagishima, Amberlynn A. Reed, Sally Temple, Dennis O. Clegg, Budd A. Tucker, Timothy A. Blenkinsop, George Harb, Thomas N. Greenwell, Tenneille E. Ludwig, Kapil Bharti   +10 more
doaj   +1 more source

The role of lipid metabolism in neuronal senescence

FEBS Open Bio, EarlyView.
Disrupted lipid metabolism, through alterations in lipid species or lipid droplet accumulation, can drive neuronal senescence. However, lipid dyshomeostasis can also occur alongside neuronal senescence, further amplifying tissue damage. Delineating how lipid‐induced senescence emerges in neurons and glial cells, and how it contributes to ageing and ...
Dikaia Tsagkari, Eleftheria Panagiotidou, Nektarios Tavernarakis   +2 more
wiley   +1 more source

Autophagy is a cell-intrinsic driver of neural stem cell quiescence in hippocampal dentate gyrus development [PDF]

, 2023
Isabel Calatayud-Baselga, Lucía Casares-Crespo, Carmina Franch-Ibáñez, José Guijarro-Nuez, Pascual Sanz, Helena Mira   +5 more
openalex   +1 more source