Results 81 to 90 of about 441,743 (344)

Improving and accelerating the differentiation and functional maturation of human stem cell-derived neurons: role of extracellular calcium and GABA [PDF]

, 2016
Neurons differentiated from pluripotent stem cells using established neural culture conditions often exhibit functional deficits. Recently, we have developed enhanced media which both synchronize the neurogenesis of pluripotent stem cell-derived neural ...
Allen, Nicholas Denby, Badder, Luned, Brown, Jonathan T., Cope, Emma Louise, Geater, Charlene, Hancock, Jane M., Hughes, Alis, Kemp, Paul J, Randall, Andrew, Riccardi, Daniela, Rushton, David J., Schnell, Christian, Telezhkin, Vsevolod, Wieland, Annalena, Yarova, Polina   +14 more
core   +1 more source

Expression and function of Ndel1 during the differentiation of neural stem cells induced by hippocampal exosomesticle [PDF]

, 2021
Wen Li, Shanshan Wang, Hui He, Jianbing Qin, Xiang Cheng, Heyan Zhao, Meiling Tian, Xinhua Zhang, Guohua Jin   +8 more
openalex   +1 more source

Transcriptional regulation of neuropeptide receptors underlies context‐dependent adaptation in Drosophila melanogaster

FEBS Open Bio, EarlyView.
Under environmental changes, the expression level of neuropeptide (NP) and neuropeptide receptor (NPR) genes changes to confer context‐dependent adaptation to the model organism Drosophila melanogaster. Through finding more regulatory elements in the NPR genes in comparison with their ligands (NPs), we found that NPR‐biased transcriptional regulation ...
SeungHeui Ryu, Yanan Wei, Zekun Wu, Tianmu Zhang, DoHoon Lee, Hadi Najafi, Woo Jae Kim   +6 more
wiley   +1 more source

A novel, long-lived, and highly engraftable immunodeficient mouse model of mucopolysaccharidosis type I

Molecular Therapy: Methods & Clinical Development, 2015
Mucopolysaccharidosis type I (MPS I) is an inherited α-L-iduronidase (IDUA, I) deficiency in which glycosaminoglycan (GAG) accumulation causes progressive multisystem organ dysfunction, neurological impairment, and death.
Daniel C Mendez, Alexander E Stover, Anthony D Rangel, David J Brick, Hubert E Nethercott, Marissa A Torres, Omar Khalid, Andrew MS Wong, Jonathan D Cooper, James V Jester, Edwin S Monuki, Cian McGuire, Steven Q Le, Shih-hsin Kan, Patricia I Dickson, Philip H Schwartz   +15 more
doaj   +1 more source

Retinoid Machinery in Distinct Neural Stem Cell Populations with Different Retinoid Responsiveness [PDF]

, 2013
Retinoic acid (RA) is present at sites of neurogenesis in both the embryonic and adult brain. While it is widely accepted that RA signaling is involved in the regulation of neural stem cell differentiation, little is known about vitamin A utilization ...
Adrienn Borsy, Barbara Orsolits, de The H, Emília Madarász, Ervin Welker, Károly Markó, Márta Jelitai, Toresson H, Tímea Kőhidi, Zsuzsanna Környei, Zsófia Mészáros   +10 more
core   +1 more source

The impact of Hnrnpl deficiency on transcriptional patterns of developing muscle cells

FEBS Open Bio, EarlyView.
We performed nanopore whole‐transcriptome sequencing comparing RNA from Hnrnpl‐knockdown versus control C2C12 myoblasts to investigate the contributions of Hnrnpl to muscle development. Our results indicate that Hnrnpl regulates the expression of genes involved with Notch signaling and skeletal muscle, particularly splicing patterns of specific muscle ...
Hannah R. Littel, Mekala Gunasekaran, Audrey L. Daugherty, Natalya M. Wells, Johnnie Turner, Christine C. Bruels, Christina A. Pacak, Isabelle Draper, Peter B. Kang   +8 more
wiley   +1 more source

Machine Learning and Medical Data: Predicting ICU Mortality and Re-admission Risks

Journal of Advanced Research in Natural and Applied Sciences
Intensive care units (ICUs) are divisions where critically ill patients are treated by medical experts. The unmet and vital need for automated clinical decision-making mechanisms is critical to maneuvering the large influx of patients.
Ulya Bayram, Runia Roy
doaj   +1 more source

Naked cuticle is essential for Drosophila wing development beyond Wingless signaling

FEBS Open Bio, EarlyView.
Naked cuticle (Nkd), a Wnt signaling inhibitor, assumes extensive roles in Drosophila wing development. Overexpressing Nkd causes smaller, crumpled wings, while also perturbing multiple signaling pathways and developmental genes. A specific region (R1S) is critical for Nkd's function as a signaling integrator, offering new insights for studying its ...
Rui Wang, Ping Wang
wiley   +1 more source

Quantified F-Actin Morphology Is Predictive of Phagocytic Capacity of Stem Cell-Derived Retinal Pigment Epithelium

Stem Cell Reports, 2018
Summary: With stem cell-derived retinal pigment epithelial (RPE) replacement therapies in clinical testing, establishing potency of RPE prior to transplantation is imperative. Phagocytosis of photoreceptor outer segment fragments (POS) is a key indicator
Claudia Müller, Carol Charniga, Sally Temple, Silvia C. Finnemann   +3 more
doaj   +1 more source

Stem cell sources and characterization in the development of cell-based products for treating retinal disease: An NEI Town Hall report

Stem Cell Research & Therapy, 2023
National Eye Institute recently issued a new Strategic Plan outlining priority research areas for the next 5 years. Starting cell source for deriving stem cell lines is as an area with gaps and opportunities for making progress in regenerative medicine ...
Ashley M. Fortress, Kiyoharu J. Miyagishima, Amberlynn A. Reed, Sally Temple, Dennis O. Clegg, Budd A. Tucker, Timothy A. Blenkinsop, George Harb, Thomas N. Greenwell, Tenneille E. Ludwig, Kapil Bharti   +10 more
doaj   +1 more source