Results 41 to 50 of about 1,237,621 (358)
Journal of Tissue Engineering and Regenerative Medicine, 2017 Three‐dimensional (3D) porous scaffolds combined with therapeutic stem cells play vital roles in tissue engineering. The adult brain has very limited regeneration ability after injuries such as trauma and stroke. In this study, injectable 3D silk fibroin‐
Wei Sun +5 more
semanticscholar +1 more source
Updated Toolbox for Assessing Neuronal Network Reconstruction after Cell Therapy
BioengineeringCell therapy has proven to be a promising treatment for a range of neurological disorders, including Parkinson Disease, drug-resistant epilepsy, and stroke, by restoring function after brain damage.
Ana Gonzalez-Ramos +3 more
doaj +1 more source
Stem Cell Reports, 2023 Summary: Models for human brain-oriented research are often established on primary cultures from rodents, which fails to recapitulate cellular specificity and molecular cues of the human brain.
Estefanía Estévez-Priego +5 more
doaj
Stem Cell Research & Therapy, 2021 Background In the brain of adult mammals, neural stem cells persist in the subventricular zone of the lateral ventricle and the subgranular zone of the dentate gyrus, which are specialized niches with proliferative capacity. Most neural stem cells are in
Wen Li +8 more
doaj +1 more source
Cell reprogramming modelled as transitions in a hierarchy of cell cycles [PDF]
J. Phys. A: Math. Theor. 50 (2017) 425601 (23pp), 2016 We construct a model of cell reprogramming (the conversion of fully differentiated cells to a state of pluripotency, known as induced pluripotent stem cells, or iPSCs) which builds on key elements of cell biology viz. cell cycles and cell lineages. Although reprogramming has been demonstrated experimentally, much of the underlying processes governing ...
arxiv +1 more source
miR-381 Regulates Neural Stem Cell Proliferation and Differentiation via Regulating Hes1 Expression.
PLoS ONE, 2015 Neural stem cells are self-renewing, multipotent and undifferentiated precursors that retain the capacity for differentiation into both glial (astrocytes and oligodendrocytes) and neuronal lineages.
Xiaodong Shi +8 more
doaj +1 more source
Novel Advancements in Three-Dimensional Neural Tissue Engineering and Regenerative Medicine [PDF]
Neural Regen. Res. 2015;10(3):352-4, 2015 Neurological diseases and injuries present some of the greatest challenges in modern medicine, often causing irreversible and lifelong burdens in the people whom they afflict. These diagnoses have devastating consequences on millions of people each year, and yet there are currently no therapies or interventions that can repair the structure of neural ...
arxiv +1 more source
Nature Communications, 2016 Transdifferentiation (TD) is a recent advancement in somatic cell reprogramming. The direct conversion of TD eliminates the pluripotent intermediate state to create cells that are ideal for personalized cell therapy.
J. Bago +8 more
semanticscholar +1 more source
Making tau amyloid models in vitro: a crucial and underestimated challenge
FEBS Letters, EarlyView.This review highlights the challenges of producing in vitro amyloid assemblies of the tau protein. We review how accurately the existing protocols mimic tau deposits found in the brain of patients affected with tauopathies. We discuss the important properties that should be considered when forming amyloids and the benchmarks that should be used to ...
Julien Broc, Clara Piersson, Yann Fichou
wiley +1 more source
Neural Regeneration Research, 2022 Our previous study showed that cell cycle exit and neuronal differentiation 1 (CEND1) may participate in neural stem cell cycle exit and oriented differentiation. However, whether CEND1-transfected neural stem cells can improve the prognosis of traumatic
Ren Wang +7 more
doaj +1 more source