Results 151 to 160 of about 38,379 (201)

Mutations of neuraminidase implicated in neuraminidase inhibitors resistance

Journal of Clinical Virology, 2008
Influenza constitutes one of the most important upper respiratory tract infections regarding morbidity, and mortality. Prevention and treatment of influenza rely on inactivated vaccines and antiviral drugs. Zanamivir and Oseltamivir, the currently available influenza neuraminidase inhibitors (NAI) can be used in clinical practice for the treatment of ...
Olivier, Ferraris, Bruno, Lina
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Neuraminidase Gangliosides Interactions

1978
Gangliosides are sialoglycolipids containing one hydrophilic (the acidic oligosaccharide) and one hydrophobic (the N-acylsphingosine) portion. Due to this chemical property they behave, in water, as soluble amphiphilic compounds and occur as free molecules (monomers), below a certain concentration, and as aggregates (micelles) over that concentration ...
G, Tettamanti, B, Cestaro, B, Venerando, A, Preti   +3 more
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Neuraminidase Inhibitors for Influenza

New England Journal of Medicine, 2005
he impact of influenza infection is felt globally each year when the disease develops in approximately 20 percent of the world’s population. In the United States, influenza infections occur in epidemics each winter, generally between late December and early March. Recent events, including human cases of avian influenza, have heightened awareness of the
exaly   +3 more sources

Neuraminidase and tumor immunotherapy

Klinische Wochenschrift, 1977
Preliminary results of first clinical studies with the enzyme neuraminidase call attention to a new kind of cancer treatment. This promising approach to tumor immunotherapy was entered into the clinical phase as a consequence of successful experimental studies in tumor-bearing mice, rats and dogs.
H H, Sedlacek, F R, Seiler, H G, Schwick
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Isoelectric focusing of neuraminidase

Experientia, 1970
Die isoelektrischen Punkte der Neuraminidasen vonVibrio cholerae (pH 4.80) undClostridium perfringens (pH 4.95) wurden mittels isoelektrischer Fokusierung bestimmt. Neuraminidasen zwei verschiedener Influenzaviren (A2/Aichi/68 und B/Mass/66) wurden entsprechend analysiert.
A R, Neurath, R W, Hartzell, B A, Rubin
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Neuraminidase assays.

Developments in biologicals, 2004
Anti-neuraminidase (NA) antibodies (Ab) play a role in protection against influenza and in combination with anti-HA Ab they increase the protection in mice. To control the NA content of vaccines, which should improve vaccine standardisation and may benefit vaccine efficacy, a series of questions must be addressed: 1) The antigenic characterization of ...
M, Aymard, O, Ferraris, L, Gerentes, J, Jolly, N, Kessler   +4 more
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Brain Neuraminidases and Gangliosides

1976
A number of data of kinetics nature indicate that brain neuraminidases (the cytosol and the membrane bound enzyme) recognize the physical state of gangliosidic substrate, with immediate modification of the activity. The interactions between the enzyme(s) and the different physical forms of the substrate are still to be studied at the molecular level ...
G, Tettamanti, B, Venerando, B, Cestaro, A, Preti   +3 more
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Substrate specificity of neuraminidases

The Histochemical Journal, 1973
This presentation is a brief description of neuraminidases and is mainly concerned with the substrate specificity of these enzymes. From the observed great differences in substrate specificity it is clear that we are dealing not with one enzyme called neuraminidase but with a variety of enzymes named neuraminidases.
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Neuraminidase-Inhibition Assay for the Identification of Influenza A Virus Neuraminidase Virus Subtype or Neuraminidase Antibody Specificity

2008
The neuraminidase-inhibition (NI) assay is a laboratory procedure for the identification of the neuraminidase (NA) glycoprotein subtype in influenza viruses or the NA subtype specificity of antibodies to influenza virus. A serological procedure for subtyping the NA glycoprotein is critical for the identification and classification of avian influenza ...
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[Neuraminidase inhibitor].

Nihon rinsho. Japanese journal of clinical medicine, 2001
Amantadine, effective to influenza A virus, is now widely used in Japan. Recently new anti-influenzal agents, neuramidase inhibitor has been developed. Both Zanamivir (inhaled type) and Oseltamivir(oral use), are proved to be effective in treatment of influenza A and B.
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