Results 211 to 220 of about 43,769 (228)
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The neuraminidases of rat eyes
Experimental Eye Research, 1973Abstract A soluble neuraminidase is present in the humors (aqueous plus vitreous) of rat eyes, while the lens contains both a soluble and a particle-bound neuraminidase. The pH optima were 4·2 for the particulate and 5·8 for both soluble enzymes.
R.E. Nordquist +2 more
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Action of Neuraminidase on Haptoglobin
Nature, 1961IN the course of work on the chemical structure of haptoglobin (Hp)1, we have had occasion to investigate the action of neuraminidase on the Hp and on the complex of Hp with haemoglobin (Hb-Hp). The neuraminidase employed was prepared as described by Mayron and Rafelson2,3 from influenza virus, Asian strain (Jap.
Jean Moretti +3 more
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Substrate specificity of neuraminidases
The Histochemical Journal, 1973This presentation is a brief description of neuraminidases and is mainly concerned with the substrate specificity of these enzymes. From the observed great differences in substrate specificity it is clear that we are dealing not with one enzyme called neuraminidase but with a variety of enzymes named neuraminidases.
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Neuraminidase inhibitors for influenza
BMJ, 2014The whole truth and nothing but the truth Informed choice requires comprehensive and credible information. Much of the rationale for the currently evolving movement to fully share data is to provide information for decision making, particularly in situations involving the need to balance the potential benefits and harms of medical products.
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Biochemical and Biophysical Research Communications, 1981
Two neuraminidase activities have been found in normal human liver, one soluble and the other particulate and essentially bound to the lysosomes. With storage of the liver at −80°C, no loss of either type of activity was noted for up to a year. KCl extracts of the soluble enzyme were stable for 15 days when stored in liquid nitrogen. For the sediments (
Denise Meyer +2 more
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Two neuraminidase activities have been found in normal human liver, one soluble and the other particulate and essentially bound to the lysosomes. With storage of the liver at −80°C, no loss of either type of activity was noted for up to a year. KCl extracts of the soluble enzyme were stable for 15 days when stored in liquid nitrogen. For the sediments (
Denise Meyer +2 more
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Zhonghua yi xue za zhi, 2010
To study the impact of avian influenza virus H5N1 neuraminidase mutations I117V, I314V and I117V + I314V on the sensibility of neuraminidase inhibitors (NAIs) and the activity of neuraminidase (NA).The mutations were introduced into NA genes of virus strain A/Vietnam/1203/04 (H5N1) by site-directed mutagenesis.
Yuhuang Zheng +4 more
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To study the impact of avian influenza virus H5N1 neuraminidase mutations I117V, I314V and I117V + I314V on the sensibility of neuraminidase inhibitors (NAIs) and the activity of neuraminidase (NA).The mutations were introduced into NA genes of virus strain A/Vietnam/1203/04 (H5N1) by site-directed mutagenesis.
Yuhuang Zheng +4 more
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Neuraminidase Gangliosides Interactions
1978Gangliosides are sialoglycolipids containing one hydrophilic (the acidic oligosaccharide) and one hydrophobic (the N-acylsphingosine) portion. Due to this chemical property they behave, in water, as soluble amphiphilic compounds and occur as free molecules (monomers), below a certain concentration, and as aggregates (micelles) over that concentration ...
Benvenuto Cestaro +3 more
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Inhibition of Neuraminidase by Polyanions
Nature, 1966THE function of viral neuraminidase (N-acetylneuraminate glycohydrolase, EC 3.2.1.18) during the reproductive cycle of myxoviruses is not yet clearly defined. It was therefore considered that potent inhibitors might be utilized to gain further insight into the role of this enzyme.
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Extracellular Streptococcal Neuraminidase [PDF]
Journal of Bacteriology, 1968 James A. Hayashi +5 more
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Neuraminidase inhibitors as antivirals
Vaccine, 2002The description of the three-dimensional structure of the influenza virus neuraminidase in 1983 opened a new phase in the search for inhibitors of the enzyme. Two compounds in late development (February 1999) have similar levels of potency against influenza A viruses, different routes of administration and, surprisingly, different resistance profiles ...
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