Results 231 to 240 of about 48,869 (270)
Some of the next articles are maybe not open access.
Neuraminidase Gangliosides Interactions
1978Gangliosides are sialoglycolipids containing one hydrophilic (the acidic oligosaccharide) and one hydrophobic (the N-acylsphingosine) portion. Due to this chemical property they behave, in water, as soluble amphiphilic compounds and occur as free molecules (monomers), below a certain concentration, and as aggregates (micelles) over that concentration ...
G, Tettamanti +3 more
openaire +2 more sources
Neuraminidase and Anti‐Neuraminidase Serum: Effect on the Cell Surface Properties
Vox Sanguinis, 1973Abstract. Neuraminidase lowers the electrical cell surface charge by cleavage of N‐acetylneuraminic acid (NANA) from the cell periphery. Neuraminidase antisera prepared in rabbits increase the surface charge density of neuraminidase‐treated cells. It is suggested that the lowering of the cell surface charge is due not only to enzymatic splitting of ...
P, Sachtleben, R, Gsell, J N, Mehrishi
openaire +2 more sources
Inhibition of Neuraminidase by Polyanions
Nature, 1966THE function of viral neuraminidase (N-acetylneuraminate glycohydrolase, EC 3.2.1.18) during the reproductive cycle of myxoviruses is not yet clearly defined. It was therefore considered that potent inhibitors might be utilized to gain further insight into the role of this enzyme.
openaire +2 more sources
Action of Neuraminidase on Haptoglobin
Nature, 1961IN the course of work on the chemical structure of haptoglobin (Hp)1, we have had occasion to investigate the action of neuraminidase on the Hp and on the complex of Hp with haemoglobin (Hb-Hp). The neuraminidase employed was prepared as described by Mayron and Rafelson2,3 from influenza virus, Asian strain (Jap.
M E, RAFELSON +3 more
openaire +2 more sources
2008
The neuraminidase-inhibition (NI) assay is a laboratory procedure for the identification of the neuraminidase (NA) glycoprotein subtype in influenza viruses or the NA subtype specificity of antibodies to influenza virus. A serological procedure for subtyping the NA glycoprotein is critical for the identification and classification of avian influenza ...
openaire +3 more sources
The neuraminidase-inhibition (NI) assay is a laboratory procedure for the identification of the neuraminidase (NA) glycoprotein subtype in influenza viruses or the NA subtype specificity of antibodies to influenza virus. A serological procedure for subtyping the NA glycoprotein is critical for the identification and classification of avian influenza ...
openaire +3 more sources
Mitogenic action of neuraminidase
Experientia, 1977A new effect of NCV on lymphocytes is demonstrated. This property is the capacity to act as a mitogen in and of itself. The possible mechanisms of this phenomenon are discussed.
SEMENZATO, GIANPIETRO CARLO +3 more
openaire +2 more sources
Neuraminidase inhibitors as antivirals
Vaccine, 2002The description of the three-dimensional structure of the influenza virus neuraminidase in 1983 opened a new phase in the search for inhibitors of the enzyme. Two compounds in late development (February 1999) have similar levels of potency against influenza A viruses, different routes of administration and, surprisingly, different resistance profiles ...
openaire +2 more sources
Biochemical and Biophysical Research Communications, 1981
Two neuraminidase activities have been found in normal human liver, one soluble and the other particulate and essentially bound to the lysosomes. With storage of the liver at −80°C, no loss of either type of activity was noted for up to a year. KCl extracts of the soluble enzyme were stable for 15 days when stored in liquid nitrogen. For the sediments (
D M, Meyer, M, Lemonnier, R, Bourrillon
openaire +2 more sources
Two neuraminidase activities have been found in normal human liver, one soluble and the other particulate and essentially bound to the lysosomes. With storage of the liver at −80°C, no loss of either type of activity was noted for up to a year. KCl extracts of the soluble enzyme were stable for 15 days when stored in liquid nitrogen. For the sediments (
D M, Meyer, M, Lemonnier, R, Bourrillon
openaire +2 more sources
Nature Microbiology, 2019
Influenza vaccine strain selection is informed by international efforts to track antigenic change, focusing on the viral hemagglutinin protein. Recent research advocates monitoring neuraminidase for immune escape mutations that could reduce vaccine efficacy.
Annette, Fox, Louise, Carolan
openaire +2 more sources
Influenza vaccine strain selection is informed by international efforts to track antigenic change, focusing on the viral hemagglutinin protein. Recent research advocates monitoring neuraminidase for immune escape mutations that could reduce vaccine efficacy.
Annette, Fox, Louise, Carolan
openaire +2 more sources
Micro Neuraminidase-Inhibition Assay for Classification of Influenza A Virus Neuraminidases
Avian Diseases, 1983A neuraminidase-inhibition (NI) assay performed in microtiter plates is described. This micro-NI assay is a modification of the NI assay recommended by the World Health Organization. It reduces the quantity of reagents required and permits antigenic classification of many isolates simultaneously.
R A, Van Deusen +3 more
openaire +2 more sources