Results 221 to 230 of about 48,869 (270)

Neuraminidase inhibitors as a strategy for influenza treatment: pros, cons and future perspectives

Expert Opinion on Pharmacotherapy, 2019
Introduction: Influenza represents a major public health threat worldwide. Implementation of good personal health and hygiene habits, together with vaccination, is the most effective tools to reduce influenza burden both in community and in healthcare ...
M. Bassetti, Nadia Castaldo, A. Carnelutti   +2 more
semanticscholar   +1 more source

Neuraminidase and tumor immunotherapy

Klinische Wochenschrift, 1977
Preliminary results of first clinical studies with the enzyme neuraminidase call attention to a new kind of cancer treatment. This promising approach to tumor immunotherapy was entered into the clinical phase as a consequence of successful experimental studies in tumor-bearing mice, rats and dogs.
H H, Sedlacek, F R, Seiler, H G, Schwick
openaire   +2 more sources

Neuraminidase inhibitor resistance in influenza: a clinical perspective

Current Opinion in Infectious Diseases, 2018
Purpose of review Neuraminidase inhibitors (NAIs), including oseltamivir, zanamivir, and peramivir, is the main class of antiviral available for clinical use.
N. Lee, A. Hurt
semanticscholar   +1 more source

Selective Inhibitors of Human Neuraminidase 1 (NEU1).

Journal of Medicinal Chemistry, 2018
Inhibitors of human neuraminidase enzymes (NEU) are recognized as important tools for the study of the biological functions of NEU and will be potent tools for elucidating the role of these enzymes in regulating the repertoire of cellular glycans.
Tianlin Guo, Rachel Heon-Roberts, Chunxia Zou, R. Zheng, A. Pshezhetsky, C. Cairo   +5 more
semanticscholar   +1 more source

Isoelectric focusing of neuraminidase

Experientia, 1970
Die isoelektrischen Punkte der Neuraminidasen vonVibrio cholerae (pH 4.80) undClostridium perfringens (pH 4.95) wurden mittels isoelektrischer Fokusierung bestimmt. Neuraminidasen zwei verschiedener Influenzaviren (A2/Aichi/68 und B/Mass/66) wurden entsprechend analysiert.
A R, Neurath, R W, Hartzell, B A, Rubin
openaire   +2 more sources

Molecular dynamics simulations of viral neuraminidase inhibitors with the human neuraminidase enzymes: Insights into isoenzyme selectivity.

Bioorganic & Medicinal Chemistry, 2018
Inhibitors of viral neuraminidase enzymes have been previously developed as therapeutics. Humans can express multiple forms of neuraminidase enzymes (NEU1, NEU2, NEU3, NEU4) that share a similar active site and enzymatic mechanism with their viral ...
M. R. Richards, Tianlin Guo, Carmanah D. Hunter, C. Cairo   +3 more
semanticscholar   +1 more source

On the intracellular uptake of neuraminidase

Experimental Cell Research, 1966
Abstract The intracellular uptake of neuraminidase by three different cell types was studied by two independent methods: (1) measurement of the electrophoretic mobility of nuclei isolated from cells with or without previous neuraminidase treatment and (2) direct observation by fluorescence microscopy of the uptake of fluorescein iso-thiocyanate ...
S, Nordling, E, Mayhew
openaire   +2 more sources

Substrate specificity of neuraminidases

The Histochemical Journal, 1973
This presentation is a brief description of neuraminidases and is mainly concerned with the substrate specificity of these enzymes. From the observed great differences in substrate specificity it is clear that we are dealing not with one enzyme called neuraminidase but with a variety of enzymes named neuraminidases.
openaire   +2 more sources

The neuraminidase of measles virus

Biochemical and Biophysical Research Communications, 1969
The agent of measles (rubeola) has been assumed to be a paramyxovirus on the basis of its electron microscopic appearance, its size, its sensitivity to ether and detergents, and the presence of hemagglutinin in the viral envelope. Thus far, however, the one attribute common to myxoviruses, namely neuraminidase, has not been described for measles virus.
C, Howe, E W, Newcomb, L T, Lee
openaire   +2 more sources

The neuraminidases of rat eyes

Experimental Eye Research, 1973
Abstract A soluble neuraminidase is present in the humors (aqueous plus vitreous) of rat eyes, while the lens contains both a soluble and a particle-bound neuraminidase. The pH optima were 4·2 for the particulate and 5·8 for both soluble enzymes.
D R, Tulsiani, R E, Nordquist, R, Carubelli   +2 more
openaire   +2 more sources