Results 211 to 220 of about 48,869 (270)

Cross-protection against highly pathogenic avian influenza H5N1 virus from seasonal influenza vaccines: a systematic review and meta-analysis of ferret studies. [PDF]

Emerg Microbes Infect
Tseng I, Huang YC, Shih WL, Chou CH, Vermund SH, Fang CT.   +5 more
europepmc   +1 more source

Strain-specific responses of avian influenza virus to disruption of solute carrier family 35 member A1 (SLC35A1) in chicken cells. [PDF]

Poult Sci
Liu H, Cruvinel JM, Warren WC, Ma W, Chen PR.   +4 more
europepmc   +1 more source

Influenza Infection in Humans Induces Broadly Cross-Reactive and Protective Neuraminidase-Reactive Antibodies

Cell, 2018
SUMMARY Antibodies to the hemagglutinin (HA) and neuraminidase (NA) glycoproteins are the major mediators of protection against influenza virus infection. Here, we report that current influenza vaccines poorly display key NA epitopes and rarely induce NA-
Yao-Qing Chen, Teddy John Wohlbold, Nai-Ying Zheng   +2 more
exaly   +2 more sources

Structural Basis of Protection against H7N9 Influenza Virus by Human Anti-N9 Neuraminidase Antibodies

Cell Host and Microbe, 2019
Influenza virus neuraminidase (NA) is a major target for small-molecule antiviral drugs. Antibodies targeting the NA surface antigen could also inhibit virus entry and egress to provide host protection.
Xueyong Zhu, Hannah L Turner, Shanshan Lang   +2 more
exaly   +2 more sources

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Mutations of neuraminidase implicated in neuraminidase inhibitors resistance

Journal of Clinical Virology, 2008
Influenza constitutes one of the most important upper respiratory tract infections regarding morbidity, and mortality. Prevention and treatment of influenza rely on inactivated vaccines and antiviral drugs. Zanamivir and Oseltamivir, the currently available influenza neuraminidase inhibitors (NAI) can be used in clinical practice for the treatment of ...
Olivier Ferraris, Bruno Lina
exaly   +3 more sources

The neuraminidase of influenza virus

Proteins: Structure, Function and Bioinformatics, 1989
AbstractIt is the enzyme neuraminidase, projecting form the surface of influenza virus particles, which allows the virus to leave infected cells and spread in the body. Antibodies which inhibit the enzyme limit the infection, but antigenic variation of the neuraminidase renders it ineffective in a vaccine.
G M Air, W G Laver
exaly   +3 more sources

Ultrasensitive Fluorogenic Reagents for Neuraminidase Titration

Angewandte Chemie - International Edition, 2017
Zhizeng Gao, Masahiro Niikura, Stephen G Withers   +2 more
exaly   +2 more sources

Impact of influenza A virus neuraminidase mutations on the stability, activity, and sensibility of the neuraminidase to neuraminidase inhibitors

Journal of Clinical Virology, 2008
The influenza neuraminidase plays a critical role in the spread of the influenza A and B viruses. Through the cleavage of terminal sialic acid from glycoconjugates, it facilitates the elution of progeny virions from infected cells and prevents their self-aggregation.Our objective was to study the impact of mutations at framework sites not under direct ...
Mathilde, Richard, Claire, Deléage, Mendy, Barthélémy, Yi Pu, Lin, Alan, Hay, Bruno, Lina, Olivier, Ferraris   +6 more
openaire   +2 more sources

Inhibitor selectivity of a new class of oseltamivir analogs against viral neuraminidase over human neuraminidase enzymes

Bioorganic and Medicinal Chemistry, 2011
The viral neuraminidase enzyme is an established target for anti-influenza pharmaceuticals. However, viral neuraminidase inhibitors could have off-target effects due to interactions with native human neuraminidase enzymes.
Amgad Albohy, Sankar Mohan, B Mario Pinto   +2 more
exaly   +1 more source