Results 261 to 270 of about 102,895 (315)
Some of the next articles are maybe not open access.
Biochemical and Biophysical Research Communications, 1981
Two neuraminidase activities have been found in normal human liver, one soluble and the other particulate and essentially bound to the lysosomes. With storage of the liver at −80°C, no loss of either type of activity was noted for up to a year. KCl extracts of the soluble enzyme were stable for 15 days when stored in liquid nitrogen. For the sediments (
D M, Meyer, M, Lemonnier, R, Bourrillon
openaire +2 more sources
Two neuraminidase activities have been found in normal human liver, one soluble and the other particulate and essentially bound to the lysosomes. With storage of the liver at −80°C, no loss of either type of activity was noted for up to a year. KCl extracts of the soluble enzyme were stable for 15 days when stored in liquid nitrogen. For the sediments (
D M, Meyer, M, Lemonnier, R, Bourrillon
openaire +2 more sources
Mutations of neuraminidase implicated in neuraminidase inhibitors resistance
Journal of Clinical Virology, 2008Influenza constitutes one of the most important upper respiratory tract infections regarding morbidity, and mortality. Prevention and treatment of influenza rely on inactivated vaccines and antiviral drugs. Zanamivir and Oseltamivir, the currently available influenza neuraminidase inhibitors (NAI) can be used in clinical practice for the treatment of ...
Olivier, Ferraris, Bruno, Lina
openaire +2 more sources
Neuraminidase inhibitors as a strategy for influenza treatment: pros, cons and future perspectives
Expert Opinion on Pharmacotherapy, 2019Introduction: Influenza represents a major public health threat worldwide. Implementation of good personal health and hygiene habits, together with vaccination, is the most effective tools to reduce influenza burden both in community and in healthcare ...
M. Bassetti +2 more
semanticscholar +1 more source
Neuraminidase Gangliosides Interactions
1978Gangliosides are sialoglycolipids containing one hydrophilic (the acidic oligosaccharide) and one hydrophobic (the N-acylsphingosine) portion. Due to this chemical property they behave, in water, as soluble amphiphilic compounds and occur as free molecules (monomers), below a certain concentration, and as aggregates (micelles) over that concentration ...
G, Tettamanti +3 more
openaire +2 more sources
Neuraminidase inhibitor resistance in influenza: a clinical perspective
Current Opinion in Infectious Diseases, 2018Purpose of review Neuraminidase inhibitors (NAIs), including oseltamivir, zanamivir, and peramivir, is the main class of antiviral available for clinical use.
N. Lee, A. Hurt
semanticscholar +1 more source
Selective Inhibitors of Human Neuraminidase 1 (NEU1).
Journal of Medicinal Chemistry, 2018Inhibitors of human neuraminidase enzymes (NEU) are recognized as important tools for the study of the biological functions of NEU and will be potent tools for elucidating the role of these enzymes in regulating the repertoire of cellular glycans.
Tianlin Guo +5 more
semanticscholar +1 more source
Bioorganic & Medicinal Chemistry, 2018
Inhibitors of viral neuraminidase enzymes have been previously developed as therapeutics. Humans can express multiple forms of neuraminidase enzymes (NEU1, NEU2, NEU3, NEU4) that share a similar active site and enzymatic mechanism with their viral ...
M. R. Richards +3 more
semanticscholar +1 more source
Inhibitors of viral neuraminidase enzymes have been previously developed as therapeutics. Humans can express multiple forms of neuraminidase enzymes (NEU1, NEU2, NEU3, NEU4) that share a similar active site and enzymatic mechanism with their viral ...
M. R. Richards +3 more
semanticscholar +1 more source
Neuraminidase and tumor immunotherapy
Klinische Wochenschrift, 1977Preliminary results of first clinical studies with the enzyme neuraminidase call attention to a new kind of cancer treatment. This promising approach to tumor immunotherapy was entered into the clinical phase as a consequence of successful experimental studies in tumor-bearing mice, rats and dogs.
H H, Sedlacek, F R, Seiler, H G, Schwick
openaire +2 more sources
Isoelectric focusing of neuraminidase
Experientia, 1970Die isoelektrischen Punkte der Neuraminidasen vonVibrio cholerae (pH 4.80) undClostridium perfringens (pH 4.95) wurden mittels isoelektrischer Fokusierung bestimmt. Neuraminidasen zwei verschiedener Influenzaviren (A2/Aichi/68 und B/Mass/66) wurden entsprechend analysiert.
A R, Neurath, R W, Hartzell, B A, Rubin
openaire +2 more sources
Developments in biologicals, 2004
Anti-neuraminidase (NA) antibodies (Ab) play a role in protection against influenza and in combination with anti-HA Ab they increase the protection in mice. To control the NA content of vaccines, which should improve vaccine standardisation and may benefit vaccine efficacy, a series of questions must be addressed: 1) The antigenic characterization of ...
M, Aymard +4 more
openaire +1 more source
Anti-neuraminidase (NA) antibodies (Ab) play a role in protection against influenza and in combination with anti-HA Ab they increase the protection in mice. To control the NA content of vaccines, which should improve vaccine standardisation and may benefit vaccine efficacy, a series of questions must be addressed: 1) The antigenic characterization of ...
M, Aymard +4 more
openaire +1 more source