Results 101 to 110 of about 134,617 (294)

A Pipeline for Volume Electron Microscopy of the Caenorhabditis elegans Nervous System. [PDF]

, 2018
The "connectome," a comprehensive wiring diagram of synaptic connectivity, is achieved through volume electron microscopy (vEM) analysis of an entire nervous system and all associated non-neuronal tissues. White et al.
Chisholm, Andrew D, Holmyard, Douglas, Meirovitch, Yaron, Mitchell, James, Mulcahy, Ben, Samuel, Aravinthan DT, Witvliet, Daniel, Zhen, Mei   +7 more
core   +1 more source

Hydrogel Confinement Strategies for 3D Cell Culture in Microfluidic Systems

Advanced Materials Technologies, EarlyView.
Hydrogel confinement structures are key to organizing 3D cell cultures in microfluidic devices. This review classifies five structural strategies (micropillar, phaseguide, porous membrane, stepped‐height, and support‐free) and examines their trade‐offs alongside fabrication methods.
Soohyun Kim, Min Seok Lee, Sung Kyun Lee
wiley   +1 more source

Downregulation of genes with a function in axon outgrowth and synapse formation in motor neurones of the VEGF(delta/delta) mouse model of amyotrophic lateral sclerosis [PDF]

, 2010
Background: Vascular endothelial growth factor (VEGF) is an endothelial cell mitogen that stimulates vasculogenesis. It has also been shown to act as a neurotrophic factor in vitro and in vivo.
Bender, F.L.P., Brockington, A., Carmeliet, P., Claes, F., Heath, P.R., Holden, H., Kasher, P., Lambrechts, D., Sendtner, M., Shaw, P.J.   +9 more
core   +4 more sources

Nanomaterial‐Based Muscle Cell/Neural Tissue Biohybrid Robots: From Actuation to Biomedical Applications

Advanced Robotics Research, EarlyView.
Muscle cell‐based biohybrid robot using nanomaterials for function enhancement and neural function for biomedical applications. Biohybrid robotics, an emerging field combining biological tissues with artificial systems, has made significant progress in developing various biohybrid constructs, including muscle‐cell‐driven biorobots and microbots.
Minkyu Shin, Sangeun Lee, Su Ryon Shin, Jin‐Ha Choi, Jeong‐Woo Choi   +4 more
wiley   +1 more source

A diffusion‐based neurite length‐sensing mechanism involved in neuronal symmetry breaking

Molecular Systems Biology, 2010
Although there has been significant progress in understanding the molecular signals that change cell morphology, mechanisms that cells use to monitor their size and length to regulate their morphology remain elusive.
Michinori Toriyama, Yuichi Sakumura, Tadayuki Shimada, Shin Ishii, Naoyuki Inagaki   +4 more
doaj   +1 more source

Reduced tubulin tyrosination as an early marker of mercury toxicity in differentiating N2a cells [PDF]

, 2007
The aims of this work were to compare the effects of methyl mercury chloride and Thimerosal on neurite/process outgrowth and microtubule proteins in differentiating mouse N2a neuroblastoma and rat C6 glioma cells.
A.J. Hargreaves, Atchison, Barra, C. Lloyd Mills, Cambray-Deakin, Castoldi, Counter, Denizot, Dringen, Erck, Flaskos, Goldman, Graff, Hajela, Hargreaves, Heidemann, Jacobson, James, Laemmli, Lowry, M. Iqbal, M. Kontovraki, M. Lawton, Miura, Olivieri, O’Kusky, Parran, Towbin, Ueha-Ishibashi, Webster   +29 more
core   +1 more source

Astrocyte Enrichment of 3D Cortical Constructs Enhances Brain Repair

Advanced Science, EarlyView.
This study highlights the role of astrocytes in supporting neural progenitor cell survival and differentiation after traumatic brain injury. Astrocytes enhanced neuronal differentiation, improved cell survival in co‐cultures, and promoted integration of microfluidics‐based implants with host tissue following implantation. Additionally, increased axonal
Elisa M. Cruz, Luana C. Soares, Gretchen Greene, Fernando Messore, Mohammed Abuelem, Mingyu Li, Caroline Andersen, Mirriam Domocos, Elisa Vitiello, Rabeah Abdul Razak, Marlene Lawston, Gabriel Moser, Talia Vasaturo‐Kolodner, Mona Barkat, Roslyn M. Bill, Edward Mann, Linna Zhou, Mootaz M. Salman, Hagan Bayley, Zoltán Molnár, Francis G. Szele   +20 more
wiley   +1 more source

Cofilactin rod formation mediates inflammation-induced neurite degeneration

Cell Reports
Summary: Stroke, trauma, and neurodegenerative disorders cause loss of neurites (axons and dendrites) in addition to neuronal death. Neurite loss may result directly from a primary insult, secondary to parental neuron death, or secondary to a post-injury
Gökhan Uruk, Ebony Mocanu, Alisa E. Shaw, James R. Bamburg, Raymond A. Swanson   +4 more
doaj   +1 more source

The functionalized amino acid (S)-Lacosamide subverts CRMP2-mediated tubulin polymerization to prevent constitutive and activity-dependent increase in neurite outgrowth

Frontiers in Cellular Neuroscience, 2014
Activity-dependent neurite outgrowth is a highly complex, regulated process with important implications for neuronal circuit remodeling in development as well as in seizure-induced sprouting in epilepsy.
Sarah M Wilson, Aubin eMoutal, Ohannes K Melemedjian, Yuying eWang, Weina eJu, Liberty eFrancois-Moutal, May eKhanna, Rajesh eKhanna   +7 more
doaj   +1 more source

The avian tectobulbar tract: development, explant culture, and effects of antibodies on the pattern of neurite outgrowth [PDF]

, 1990
The tectobulbar tract is the first long-distance projecting fiber pathway to appear during the development of the avian optic tectum (dorsal half of the mesencephalon).
Kröger, Stephan, Schwarz, U.
core   +2 more sources