Results 81 to 90 of about 134,617 (294)

Structural aging of human neurons is opposite of the changes in schizophrenia.

PLoS ONE, 2023
Human mentality develops with age and is altered in psychiatric disorders, though their underlying mechanism is unknown. In this study, we analyzed nanometer-scale three-dimensional structures of brain tissues of the anterior cingulate cortex from eight ...
Ryuta Mizutani, Rino Saiga, Yoshiro Yamamoto, Masayuki Uesugi, Akihisa Takeuchi, Kentaro Uesugi, Yasuko Terada, Yoshio Suzuki, Vincent De Andrade, Francesco De Carlo, Susumu Takekoshi, Chie Inomoto, Naoya Nakamura, Youta Torii, Itaru Kushima, Shuji Iritani, Norio Ozaki, Kenichi Oshima, Masanari Itokawa, Makoto Arai   +19 more
doaj   +1 more source

Mitochondria modulate programmed neuritic retraction [PDF]

Proceedings of the National Academy of Sciences, 2018
Significance Neuritic retraction in the absence of overt neuronal death occurs during aging and early in neurodegenerative disorders. However, mechanisms responsible for physiologic and pathologic neuritic retraction are unknown. We demonstrate that progressive distal mitochondrial protein damage, resulting in impaired mitochondrial protein ...
Sergei V, Baranov, Oxana V, Baranova, Svitlana, Yablonska, Yalikun, Suofu, Alberto L, Vazquez, Takashi D Y, Kozai, X Tracy, Cui, Lisa M, Ferrando, Timothy M, Larkin, Yulia Y, Tyurina, Valerian E, Kagan, Diane L, Carlisle, Bruce S, Kristal, Robert M, Friedlander   +13 more
openaire   +2 more sources

Decellularized Extracellular Matrix (dECM) in Tendon Regeneration: A Comprehensive Review

Advanced Healthcare Materials, EarlyView.
Decellularized Extracellular Matrix (dECM) offers a promising solution by replicating the native tendon microenvironment and promoting regeneration. This review highlights advances in the decellularization methods, as well as their integration with emerging technologies and translational progress in tendon tissue engineering.
Kumaresan Sakthiabirami, Yeonwoo Park, Seong Kyeong Jo, Min Hee Kim, Jae Hwang Song   +4 more
wiley   +1 more source

Restoration from polyglutamine toxicity after free electron laser irradiation of neuron-like cells [PDF]

, 2019
学位記番号 ...
Mohara, Miho, モハラ, ミホ, 茂原, 美穂   +2 more
core  

Isolation, characterization, and substrate properties of the external limiting membrane from the avian embryonic optic tectum [PDF]

, 1990
The external limiting membrane of the avian embryonic optic tectum is isolated by mechanically separating the neuronal mesencephalon from the overlying mesenchymal tissue.
Adler, Anderson, Avnur, Bodick, Bonhoeffer, Bovolenta, Condic, Davis, DeLong, Dodd, Dow, Dziadek, Dziadek, Easter, Fallon, Goldberg, Halfter, Halfter, Halfter, Halfter, Halfter, Hantaz-Ambroise, Harris, Hinds, Holley, Holt, Kanwar, Kuffler, Kuwada, Letourneau, Manthorpe, Matsusaka, Nakamura, Nardi, Newgreen, Newgreen, Nordlander, Patterson, Puelles, Rager, Reynolds, Roberts, Rogers, Rösner, Rösner, Sanes, Scherer, Schittny, Silver, Singer, Thanos, Thanos, Thanos, Timpl, Timpl, Vanselow, Walter, Walter, Williams   +58 more
core   +1 more source

Targeting the ARRDC3–DRP1 Axis via hUMSC‐Derived Exosomal CRYAB for Neuroprotection in Cerebral Ischemia/Reperfusion Injury

Advanced Healthcare Materials, EarlyView.
Intranasally administered hUMSC‐derived exosomes modulate the CRYAB–ARRDC3–Drp1 axis, alleviating mitochondrial dysfunction and ferroptosis, enhancing neuronal survival, reducing oxidative stress, and promoting functional recovery in ischemia‐reperfusion injury, offering a promising therapeutic strategy for ischemic stroke.
Rong ji, Zengyu Zhang, Zhuohang Liu, Kaicheng Yang, Xueyu Mao, Min Chu, Yong Wang, Jing Zhao   +7 more
wiley   +1 more source

Muscarinic Acetylcholine Type 1 Receptor Activity Constrains Neurite Outgrowth by Inhibiting Microtubule Polymerization and Mitochondrial Trafficking in Adult Sensory Neurons

Frontiers in Neuroscience, 2018
The muscarinic acetylcholine type 1 receptor (M1R) is a metabotropic G protein-coupled receptor. Knockout of M1R or exposure to selective or specific receptor antagonists elevates neurite outgrowth in adult sensory neurons and is therapeutic in diverse ...
Mohammad G. Sabbir, Nigel A. Calcutt, Paul Fernyhough, Paul Fernyhough   +3 more
doaj   +1 more source

Caldendrin represses neurite regeneration and growth in dorsal root ganglion neurons

Scientific Reports, 2023
Caldendrin is a Ca2+ binding protein that interacts with multiple effectors, such as the Cav1 L-type Ca2+ channel, which play a prominent role in regulating the outgrowth of dendrites and axons (i.e., neurites) during development and in response to ...
Josue A. Lopez, Annamarie Yamamoto, Joseph T. Vecchi, Jussara Hagen, Kyungmoo Lee, Milan Sonka, Marlan R. Hansen, Amy Lee   +7 more
doaj   +1 more source

Interactions of a neuronal cell line (PC12) with laminin, collagen IV, and fibronectin: identification of integrin-related glycoproteins involved in attachment and process outgrowth. [PDF]

, 1987
Neuronal responses to extracellular matrix (ECM) constituents are likely to play an important role in nervous system development and regeneration. We have studied the interactions of a neuron-like rat pheochromocytoma cell line, PC12, with ECM protein ...
Damsky, CH, Reichardt, LF, Tomaselli, KJ
core  

Boron‐Doped Nano‐Crystalline Coated Carbon Fibers for Phasic Dopamine Sensing

Advanced Healthcare Materials, EarlyView.
This uniform coating presents a mix of graphitic and diamond‐like carbon to create a mechanically and electrically robust alternative for the electrochemical detection of dopamine. The electrodes in this work possess the equivalent sensitivity to the state‐of‐the‐art FSCV dopamine detecting electrodes, whilst demonstrating an ability to withstand ...
Simon J. Higham, Juan M. Rojas Cabrera, Youngjong Kwak, Lydia Hong, Andre Chambers, Athavan Nadarajah, Sorel E. De Leon, Young Jun Jung, Negin Jalilinejad, Charles Blaha, Dong Pyo Jang, Yoonbae Oh, Kendall Lee, Alastair Stacey, Shaun L. Cloherty, Michael R. Ibbotson, David J. Garrett, Steven Prawer, Hojin Shin, Wei Tong   +19 more
wiley   +1 more source