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ETFDH mutation involves excessive apoptosis and neurite outgrowth defect via Bcl2 pathway. [PDF]
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Involvement of Akt in neurite outgrowth
Cellular and Molecular Life Sciences, 2009The regulation of neuronal differentiation and neurite outgrowth is essential during development of the nervous system and is crucial in developing therapies to promote axon regeneration after nerve injury or in neurodegenerative diseases. The serine/threonine kinase Akt has been well documented to promote neuronal survival.
Adrienne M Gorman
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Enhancing and Regulating Neurite Outgrowth
Critical Reviews in Toxicology, 2008Numerous agents have demonstrated the potential to enhance neuronal repair following spinal cord or peripheral nerve injury using neurite outgrowth as a biomarker for axonal extension in primary cell cultures and neuronal cell lines. This article provides an assessment of the dose-response features of chemically induced neuronal outgrowth in a broad ...
Edward Calabrese
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Inhibitor of neurite outgrowth in humans
Nature, 2000Axons are generally believed to be incapable of regeneration in the adult central nervous system1,2. Inhibition results from physical barriers imposed by glial scars, a lack of neurotrophic factors, and growth-inhibitory molecules associated with myelin3,4,5, the insulating axon sheath.
R, Prinjha +8 more
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An algorithm for neurite outgrowth reconstruction
Journal of Neuroscience Methods, 2003We present a numerical method which provides the ability to analyze digitized microscope images of retinal explants and quantify neurite outgrowth. Few parameters are required as input and limited user interaction is necessary to process an entire experiment of images.
Christina M, Weaver +3 more
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Extracellular matrix and neurite outgrowth
Current Opinion in Genetics & Development, 1992The complex relationship between neuronal cells and the extracellular matrix molecules with which they interact both positively and negatively is currently being investigated on many fronts. Major areas of experimental emphasis include the characterization of an increasing number of extracellular matrix and cell surface associated molecules, the ...
P C, Letourneau, M L, Condic, D M, Snow
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Mechanosensitive Channels in Neurite Outgrowth
2007This chapter focuses on the convergence of two areas of investigation in the past: the first is the study of the molecular basis for Ca(2+)-dependent axon pathfinding, and the second is the molecular and the functional characterization of mechanosensitive Ca(2+)-permeant cation channels (MscCa). The convergence of these two fields has reached a pivotal
PELLEGRINO, MARIO, PELLEGRINI M.
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Nanomodified surfaces and neurite outgrowth
2011Here we describe our attempts to study the interaction of nanomodified surfaces with neurons and macrophages. Surfaces with nano-sized topographies produced by UV lithography, electrochemical etching, nanoimprint lithography, microdispensing, or by electrospinning of plastic nanofibers or by making plastic replicas of the extracellular matrix with ...
Martin, Kanje, Fredrik, Johansson
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An inhibitor of neurite outgrowth produced by astrocytes
Journal of Cell Science, 1994ABSTRACT We have produced a number of astrocytic cell lines, some of which promote abundant neurite outgrowth, some of which are poor promoters of neurite outgrowth. The critical difference between these lines lies in the extracellular matrix, cell lines that are good promoters of axon growth producing a matrix that promotes axon growth,
L C, Smith-Thomas +8 more
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The Logic of Neurite Outgrowth
Science Signaling, 2008Cannabinoid receptor 1 (CB1R) regulates neurite outgrowth, has important functions in central nervous system development, and is a drug target for several diseases. Bromberg et al . used a combination of transcriptional profiling on DNA arrays with graph theory analysis of known signaling networks to explore the ...
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