Results 1 to 10 of about 5,460 (136)

Neuroactive Steroid–Gut Microbiota Interaction in T2DM Diabetic Encephalopathy [PDF]

Biomolecules, 2023
The pathological consequences of type 2 diabetes mellitus (T2DM) also involve the central nervous system; indeed, T2DM patients suffer from learning and memory disabilities with a higher risk of developing dementia.
Silvia Diviccaro, Lucia Cioffi, Rocco Piazza, Donatella Caruso, Roberto Cosimo Melcangi, Silvia Giatti   +5 more
doaj   +2 more sources

Widespread Cortical Thickness Is Associated With Neuroactive Steroid Levels [PDF]

Frontiers in Neuroscience, 2019
BackgroundNeuroactive steroids are endogenous molecules with regenerative and neuroprotective actions. Both cortical thickness and many neuroactive steroid levels decline with age and are decreased in several neuropsychiatric disorders.
Rajendra A. Morey, Rajendra A. Morey, Rajendra A. Morey, Sarah L. Davis, Sarah L. Davis, Courtney C. Haswell, Courtney C. Haswell, Jennifer C. Naylor, Jennifer C. Naylor, Jason D. Kilts, Jason D. Kilts, Steven T. Szabo, Steven T. Szabo, Larry J. Shampine, Larry J. Shampine, Gillian J. Parke, Gillian J. Parke, Delin Sun, Delin Sun, Chelsea A. Swanson, Chelsea A. Swanson, Henry R. Wagner, Henry R. Wagner, Henry R. Wagner, Mid-Atlantic MIRECC Workgroup, Christine E. Marx, Christine E. Marx   +26 more
doaj   +2 more sources

Electrophysiological Characterization of Sex-Dependent Hypnosis by an Endogenous Neuroactive Steroid Epipregnanolone [PDF]

Biomolecules
Neuroactive steroids (NAS) have long been recognized for their hypnotic and anesthetic properties in both clinical and preclinical settings. While sex differences in NAS sensitivity are acknowledged, the underlying mechanisms remain poorly understood ...
Tamara Timic Stamenic, Ian Coulter, Douglas F. Covey, Slobodan M. Todorovic   +3 more
doaj   +2 more sources

Realising the therapeutic potential of neuroactive steroid modulators of the GABAA receptor [PDF]

Neurobiology of Stress, 2020
In the 1980s particular endogenous metabolites of progesterone and of deoxycorticosterone were revealed to be potent, efficacious, positive allosteric modulators (PAMs) of the GABAA receptor (GABAAR).
Delia Belelli, Derk Hogenkamp, Kelvin W. Gee, Jeremy J. Lambert   +3 more
doaj   +2 more sources

Comparative electrophysiological study of neuroactive steroid-induced hypnosis in mice: sex and drug-specific differences [PDF]

Experimental Biology and Medicine
Since the discovery of their anesthetic effects, some neuroactive steroids have been used as general anesthetics. However, their effects on thalamocortical oscillations and potential sex differences that are associated with their hypnotic/sedative ...
Abigail Martin, Ian Coulter, Reginald Cox, Douglas F. Covey, Douglas F. Covey, Slobodan M. Todorovic, Slobodan M. Todorovic, Tamara Timic Stamenic   +7 more
doaj   +2 more sources

An open-label, proof-of-mechanism trial evaluating a neuroactive steroid GABA modulator in tinnitus [PDF]

Frontiers in Neurology
Imbalances of excitatory and inhibitory signaling within the central auditory pathways are hypothesized to underlie tinnitus pathophysiology. Neuroactive steroids, such as allopregnanolone, are positive allosteric modulators of GABAA receptors that ...
Luke S. Watson, Patricio O’Donnell, Kemi Bankole, Youssef Toubouti, Richard S. Tyler, Richard S. Tyler, Jason K. Johannesen   +6 more
doaj   +2 more sources

Advances in pharmacotherapy for postpartum depression: a structured review of standard-of-care antidepressants and novel neuroactive steroid antidepressants [PDF]

Therapeutic Advances in Psychopharmacology, 2022
Postpartum depression is one of the most common morbidities of childbearing, yet it is underdiagnosed and undertreated with negative consequences for mother and offspring.
Yardana Kaufman, Sara V. Carlini, Kristina M. Deligiannidis   +2 more
doaj   +2 more sources

The Neuroactive Steroid Pregnanolone Glutamate: Anticonvulsant Effect, Metabolites and Its Effect on Neurosteroid Levels in Developing Rat Brains [PDF]

Pharmaceuticals, 2021
Pregnanolone glutamate (PA-G) is a neuroactive steroid that has been previously demonstrated to be a potent neuroprotective compound in several biological models in vivo.
Eva Kudova, Pavel Mares, Martin Hill, Katerina Vondrakova, Grygoriy Tsenov, Hana Chodounska, Hana Kubova, Karel Vales   +7 more
doaj   +2 more sources

Neuroactive steroids in the programming of neurodevelopment: implications of maternal obesity [PDF]

Frontiers in Endocrinology
Neuroactive steroids synthesized within the maternal-placental-fetal unit play a crucial role in fetal neurodevelopment by regulating cell proliferation, migration, and myelination, neurogenesis, gliogenesis, and synaptogenesis, ultimately shaping brain ...
Carmen J. Zamora-Sánchez, Juan Carlos González-Orozco, Jonatan Mendoza-Ortega, Jonatan Mendoza-Ortega, Mariana L. Villegas-Soto, Ignacio Camacho-Arroyo, Guadalupe Estrada-Gutierrez   +6 more
doaj   +2 more sources

Novel Inhibitory Actions of Neuroactive Steroid [3α,5α]-3-Hydroxypregnan-20-One on Toll-like Receptor 4-Dependent Neuroimmune Signaling [PDF]

Biomolecules
The endogenous neurosteroid (3α,5α)-3-hydroxypregnan-20-one (3α,5α-THP) modulates inflammatory and neuroinflammatory signaling through toll-like receptors (TLRs) in human and mouse macrophages, human blood cells and alcohol-preferring (P) rat brains ...
Alejandro G. Lopez, Venkat R. Chirasani, Irina Balan, Todd K. O’Buckley, Makayla R. Adelman, A. Leslie Morrow   +5 more
doaj   +2 more sources