Results 131 to 140 of about 5,499 (175)
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Social isolation stress and neuroactive steroids
European Neuropsychopharmacology, 2007Social isolation of rats immediately after weaning is associated to a reduction in the cerebrocortical and plasma concentrations of progesterone and its metabolites 3alpha,5alpha-TH PROG and 3alpha,5alpha-THDOC. Although we found that the basal plasma concentration of adrenocorticotropic hormone in isolated rats was slightly decreased compared with ...
SERRA, MARIANGELA +3 more
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Neuroactive Steroids and Neuroinflammation
2016Neuroinflammatory condition is a common characteristic shared by different neurodegenerative diseases. To date, therapeutic interventions able to stop neuroinflammation and promote repair is still lacking. Neuroactive steroids are cholesterol-derived molecules that exert their functions acting on the central nervous system.
Giatti S., Melcangi R. C.
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Neuroactive steroids modulate crustacean locomotor activity
Neuroscience Letters, 2001We examined the effects of neuroactive steroids known to modulate gamma-aminobutyric acid(A) (GABA)(A) receptor activity, on locomotor activity in a submerged circular open-field apparatus. Juvenile male lobsters, Homarus americanus, were treated with a single administration of an agonist, 3alpha-hydroxy-5alpha-pregnan-20-one (allopregnanolone, 3alpha ...
M J, Snyder, H V, Peeke
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Steroids, neuroactive steroids and neurosteroids in psychopathology
Progress in Neuro-Psychopharmacology and Biological Psychiatry, 2005The term "neurosteroid" (NS) was introduced by Baulieu in 1981 to name a steroid hormone, dehydroepiandrosterone sulfate (DHEAS), that was found at high levels in the brain long after gonadectomy and adrenalectomy, and shown later to be synthetized by the brain.
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Neuroactive steroids and peripheral myelin proteins
Brain Research Reviews, 2001The present review summarizes observations obtained in our laboratories which underline the importance of neuroactive steroids (i.e., progesterone (PROG), dihydroprogesterone (5alpha-DH PROG), tetrahydroprogesterone (3alpha, 5alpha-TH PROG), testosterone (T), dihydrotestosterone (DHT) and 5alpha-androstan-3alpha,17beta-diol (3alpha-diol)) in the ...
V. Magnaghi +4 more
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Pharmacology of Endogenous Neuroactive Steroids
Critical Reviews? in Neurobiology, 2004Neuroactive steroids are potent endogenous neuromodulators with rapid actions in the central nervous system. Neuroactive steroids have been claimed to have specific physiological roles in normal or pathological brain function. This article reviews the emerging evidence that progesterone-, deoxycorticosterone-, and testosterone-derived endogenous ...
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Breakthroughs in neuroactive steroid drug discovery
Bioorganic & Medicinal Chemistry Letters, 2018Endogenous and synthetic neuroactive steroids (NASs) or neurosteroids are effective modulators of multiple signaling pathways including receptors for the γ-aminobutyric acid A (GABAA) and glutamate, in particular N-methyl-d-aspartate (NMDA). These receptors are the major inhibitory and excitatory neurotransmitters in the central nervous system (CNS ...
Maria-Jesus Blanco +6 more
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Progesterone receptor-mediated effects of neuroactive steroids
Neuron, 1993Several 3 alpha-hydroxysteroids accumulate in the brain after local synthesis or after metabolization of steroids that are provided by the adrenals. The 3 alpha-hydroxy ring A-reduced pregnane steroids allopregnanolone and tetrahydrodeoxycorticosterone are believed not to interact with intracellular receptors, but enhance GABA-mediated chloride ...
Rupprecht, R +7 more
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The neuropsychopharmacological potential of neuroactive steroids
Journal of Psychiatric Research, 1997In addition to the well-known genomic effects of steroid molecules via intracellular steroid receptors, certain steroids rapidly alter neuronal excitability through interaction with neurotransmitter-gated ion channels. Several of these steroids accumulate in the brain after local synthesis or after metabolism of adrenal steroids.
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