LPM682000012, a Synthetic Neuroactive Steroid That Ameliorates Epileptic Seizures by Downregulating the Serpina3n/NF-κB Signaling Pathway [PDF]
MoleculesEpilepsy is characterized by abnormal neuronal firing in the brain. Several therapeutic strategies exist for epilepsy; however, several patients remain poorly treated.
Xiaofan Zhang +9 more
doaj +2 more sources
Epigenetic dysregulation of steroidogenesis and neuroactive steroid deficiency in premature ovarian insufficiency: implications for neurodegenerative risk [PDF]
Biomarker ResearchPremature ovarian insufficiency (POI) is associated with an increased risk of neurodegenerative diseases, but the underlying mechanisms remain unclear.
Qian Wang +8 more
doaj +2 more sources
Neuroactive steroid effects on autophagy in a human embryonic kidney 293 (HEK) cell model [PDF]
Scientific ReportsNeuropsychiatric and neurodegenerative disorders are correlated with cellular stress. Macroautophagy (autophagy) may represent an important protective pathway to maintain cellular homeostasis and functionality, as it targets cytoplasmic components to ...
Sofia V. Salvatore +8 more
doaj +2 more sources
Expanding our understanding of (mal)adapted stress physiology in psychiatric disorders: achieving single-cell characterisation of steroids and neuropeptides [PDF]
Neurobiology of StressSteroid hormones and neurosteroids (collectively neuroactive steroids), alongside neuropeptides, are key modulators of the central nervous system. These signalling molecules integrate environmental cues into neurobiological responses by regulating gene ...
Katrina Z. Edmond, Natalie Matosin
doaj +2 more sources
Analytical Methods for the Determination of Neuroactive Steroids
Biomolecules, 2021 Neuroactive steroids are a family of all steroid-based compounds, of both natural and synthetic origin, which can affect the nervous system functions.
Michal Kaleta +3 more
doaj +1 more source
Frontiers in Psychiatry, 2023 IntroductionBenzodiazepines (BZs) are prescribed as anxiolytics, but their use is limited by side effects including abuse liability and daytime drowsiness.
Jemma E. Cook +3 more
doaj +1 more source
Steroid Sulfation in Neurodegenerative Diseases
Frontiers in Molecular Biosciences, 2022 Steroid sulfation and desulfation participates in the regulation of steroid bioactivity, metabolism and transport. The authors focused on sulfation and desulfation balance in three neurodegenerative diseases: Alzheimer´s disease (AD), Parkinson´s disease
Jana Vitku +4 more
doaj +1 more source
Neuroactive Steroids in Schizophrenia [PDF]
The Canadian Journal of Psychiatry, 2005 Schizophrenia is a psychiatric disorder with a complicated pathophysiology, involving many biochemical abnormalities in the brain. Because neuroactive steroids (NASs) modulate neurotransmitter systems that are implicated in the pathology of schizophrenia, recent research has focused on examining the role that NASs play in the illness.
Yanina, Shulman, Philip G, Tibbo
openaire +2 more sources
Biomolecules, 2022 Chronic cocaine use leads to adaptations in stress biology and in neuroactive steroid system. These adaptations are associated with high cocaine craving and increased relapse risk.
Verica Milivojevic +4 more
doaj +1 more source
Axonal transport in a peripheral diabetic neuropathy model: sex-dimorphic features
Biology of Sex Differences, 2018 Background Disruption of axonal transport plays a pivotal role in diabetic neuropathy. A sex-dimorphism exists in the incidence and symptomatology of diabetic neuropathy; however, no studies so far have addressed sex differences in axonal motor proteins ...
Marzia Pesaresi +9 more
doaj +1 more source