Results 21 to 30 of about 5,499 (175)
Biomolecules, 2023 Background: Allopregnanolone is one of the most studied neuroactive steroids; yet, despite its relevance to neuropsychiatric research, it is not known how it, as well as its ratio to progesterone, varies across all six subphases of the menstrual cycle ...
Ajna Hamidovic +4 more
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Stress, ethanol, and neuroactive steroids [PDF]
Pharmacology & Therapeutics, 2007 Neurosteroids play a crucial role in stress, alcohol dependence and withdrawal, and other physiological and pharmacological actions by potentiating or inhibiting neurotransmitter action. This review article focuses on data showing that the interaction among stress, ethanol, and neuroactive steroids may result in plastic molecular and functional changes
Biggio G +4 more
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Frontiers in Pharmacology, 2016 Endogenous neurosteroids and neuroactive steroids have potent and widespread actions on the brain via inhibitory GABAA receptors. In recombinant receptors and genetic mouse models their actions depend on the alpha, beta and delta subunits of the receptor,
Elli Leppä +8 more
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Allopregnanolone in the bed nucleus of the stria terminalis modulates contextual fear in rats
Frontiers in Behavioral Neuroscience, 2015 Trauma- and stress-related disorders are among the most common types of mental illness affecting the U.S. population. For many of these disorders, there is a striking sex difference in lifetime prevalence; for instance, women are twice as likely as men ...
Naomi eNagaya +4 more
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The Allopregnanolone Response to Acute Stress in Females: Preclinical and Clinical Studies
Biomolecules, 2022 The neuroactive steroid allopregnanolone ((3α,5α)-3-hydroxypregnan-20-one or 3α,5α-THP) plays a key role in the response to stress, by normalizing hypothalamic-pituitary-adrenal (HPA) axis function to restore homeostasis. Most studies have been conducted
Maria Giuseppina Pisu +4 more
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Neuroactive steroids and the new decade [PDF]
Journal of Neuroendocrinology, 2020 The term ‘neurosteroids’ started to be used in the 1980s to indicate a family of steroids synthesised within the brain and regulating, via steroid receptors or other receptors, several brain functions. Later on, the term ‘neuroactive steroids’ was introduced to include those steroids that are not synthesised in the brain or are only partly me ...
Giancarlo Panzica, Roberto C. Melcangi
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Genomic and Non-genomic Action of Neurosteroids in the Peripheral Nervous System
Frontiers in Neuroscience, 2020 Since the former evidence of biologic actions of neurosteroids in the central nervous system, also the peripheral nervous system (PNS) was reported as a structure affected by these substances.
Alessandra Colciago +3 more
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Cells, 2020 Protein kinase type C-ε (PKCε) plays important roles in the sensitization of primary afferent nociceptors, such as ion channel phosphorylation, that in turn promotes mechanical hyperalgesia and pain chronification.
Veronica Bonalume +10 more
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Neuroactive steroids and peripheral neuropathy
Brain Research Reviews, 2008 Peripheral neuropathy, either inherited or acquired, represents a very common disorder for which effective clinical treatments are not available yet. Observations here summarized indicate that neuroactive steroids, such as progesterone, testosterone and their reduced metabolites, might represent a promising therapeutic option.
I. Roglio +7 more
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Archives of Epilepsy, 2018 When seizures occur in clusters during certain stages of the menstrual cycle (perimenstrual and periovulatory stages), it is defined as catamenial epilepsy. The prevalence varies between 10% and 70%.
Rabia Gökçen GÖZÜBATIK ÇELİK +1 more
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