Results 41 to 50 of about 5,499 (175)

Neuroactive steroids and metabolic axis

Frontiers in Neuroendocrinology, 2018
Neuroactive steroids (i.e., steroids synthesised both in peripheral glands and in nervous system) are important physiological regulators of the nervous functions. In particular, they are involved in the control of many physiological aspects of reproduction, stress response, and metabolism, as well as in several pathologies including depression, obesity,
Melcangi, R. C., Panzica, G. C.
openaire   +3 more sources

Tandem MADS‐Box Genes FUL2 and MADS1 Form a Regulatory Module to Repress Serotonin Biosynthesis via Direct ASMT5 Activation in Tomato Fruit

Plant Biotechnology Journal, EarlyView.
ABSTRACT The regulation of serotonin metabolism during fruit development and ripening remains poorly understood, despite its potential roles in plant defence and human nutrition. Here, we demonstrated that the MADS‐box transcription factor FUL2 acts as a key repressor of serotonin accumulation in tomato by forming a functional module with MADS1. CRISPR‐
Yaping Xu, Huimin Jia, Dengguo Tang, Lijun Zhang, Xinqin Liu, Junjie Rong, Yunai Lv, Zhaobo Lang, Qingfeng Niu   +8 more
wiley   +1 more source

Distinct mechanisms of allopregnanolone and diazepam underlie neuronal oscillations and differential antidepressant effect

Frontiers in Cellular Neuroscience
The rapid relief of depressive symptoms is a major medical requirement for effective treatments for major depressive disorder (MDD). A decrease in neuroactive steroids contributes to the pathophysiological mechanisms associated with the neurological ...
Keiko Takasu, Yosuke Yawata, Ryoichi Tashima, Hiroyuki Aritomi, Shinji Shimada, Tsukasa Onodera, Teruhiko Taishi, Koichi Ogawa   +7 more
doaj   +1 more source

Menstrual cycle effects on sex differences in motor control during dynamic balance perturbations

Experimental Physiology, EarlyView.
Abstract This study investigated sex differences in neuromuscular responses during dynamic balance perturbations and isometric maximal voluntary contractions (IMVCs) by examining if menstrual cycle (MC) phase and the fluctuations in endogenous hormones influence the observation of sex differences.
Samuli Nevanperä, Ritva S. Mikkonen, Simon Walker, Jarmo M. Piirainen   +3 more
wiley   +1 more source

Multiple sclerosis lesions exhibit sex-specific steroid changes

Neurobiology of Disease
Sex differences in disease susceptibility and progression in multiple sclerosis (MS) indicate hormonal influences. We previously found sex differences in steroidogenic enzyme expression in mixed active/inactive (mixed) and inactive lesions, suggesting ...
Sabina Luchetti, Matthew R.J. Mason, Philippe Liere, Antoine Pianos, Sara Cossu, Marloes Hofstee, Arja Sluiter, Adelia, Jackelien van Scheppingen, Eleonora Aronica, Michael Schumacher, Inge Huitinga   +11 more
doaj   +1 more source

Unraveling Chronic Pain: From Mechanisms and Risks to Diagnosis and Treatment

MedComm, Volume 7, Issue 4, April 2026.
Chronic pain arises through distinct molecular pathways categorized into nociceptive, neuropathic, and nociplastic types. Nociceptive pain begins with TRP channel activation in peripheral nociceptors, signaling via Aδ‐ and C‐fibers through the spinal dorsal horn and spinothalamic tracts to the brain, regulated by descending inhibition and involving ...
Xiaofeng Dai, Chongxiang Wang, Ping Jiang, Xiaopeng Mei   +3 more
wiley   +1 more source

Neurosteroids as novel antidepressants and anxiolytics: GABA-A receptors and beyond

Neurobiology of Stress, 2019
The recent FDA approval of the neurosteroid, brexanolone (allopregnanolone), as a treatment for women with postpartum depression, and successful trials of a related neuroactive steroid, SGE-217, for men and women with major depressive disorder offer the ...
Charles F. Zorumski, Steven M. Paul, Douglas F. Covey, Steven Mennerick   +3 more
doaj   +1 more source

Mechanisms of action of Zishen Yutai pills in treating premature ovarian failure determined by integrating UHPLC-Q-TOF-MS and network pharmacology analysis

BMC Complementary Medicine and Therapies, 2022
Background Zishen Yutai (ZSYT) pill, a patent Chinese medicine, has been widely used in the treatment of infertility, abortion, and adjunctive treatment of in vitro fertilization (IVF) for decades.
Lei Dang, Chunbo Zhang, Biru Su, Na Ning, Qiuling Huang, Su Zhou, Meng Wu, Wenqing Ma, Man Wang, Pengfei Cui, Yan Li, Shixuan Wang   +11 more
doaj   +1 more source

Intravenous ganaxolone in pediatric super-refractory status epilepticus: A single hospital experience

Epilepsy & Behavior Reports, 2022
Synaptic GABAA receptor (GABAAR) internalization contributes to the drug resistant nature of super-refractory status epilepticus (SRSE). Ganaxolone is a 3β-methylated synthetic analog of the endogenous neuroactive steroid, allopregnanolone, that has ...
Rani K. Singh, Rajdeep Singh, Alejandra Stewart, Katherine Van Poppel, Sarah Klinger, Joseph Hulihan, Heather Van Heusen, Henrikas Vaitkevicius, Maciej Gasior   +8 more
doaj   +1 more source

Neuroactive steroids, their metabolites, and neuroinflammation [PDF]

Journal of Molecular Endocrinology, 2012
Neuroinflammation represents a common feature of many neurodegenerative diseases implicated both in their onset and progression. Neuroactive steroids act as physiological regulators and protective agents in the nervous system. Therefore, the attention of biomedical research has been recently addressed in evaluating whether neuroactive steroids, such as
S. Giatti, M. Boraso, R.C. Melcangi, B. Viviani   +3 more
openaire   +3 more sources