Results 81 to 90 of about 5,499 (175)

NEUROACTIVE STEROIDS [PDF]

Pediatric Research, 1993
openaire   +1 more source

Sex-specific hypnotic effects of the neuroactive steroid (3β,5β,17β)-3-hydroxyandrostane-17-carbonitrile are mediated by peripheral metabolism into an active hypnotic steroid. [PDF]

Br J Anaesth, 2023
Manzella FM, Cabrera OH, Wilkey D, Fine-Raquet B, Klawitter J, Krishnan K, Covey DF, Jevtovic-Todorovic V, Todorovic SM.   +8 more
europepmc   +1 more source

A neuroactive steroid with a therapeutically interesting constellation of actions at GABA_A and NMDA receptors. [PDF]

Neuropharmacology, 2021
Ziolkowski L, Mordukhovich I, Chen DM, Chisari M, Shu HJ, Lambert PM, Qian M, Zorumski CF, Covey DF, Mennerick S.   +9 more
europepmc   +1 more source

Gut dysbiosis mediates neurotoxic effects of environmentally relevant tylosin exposure in adult zebrafish

Ecotoxicology and Environmental Safety
Tylosin, a widely used veterinary macrolide antibiotic, raises environmental concerns due to its persistence and potential health risks. However, the neurotoxic effects of chronic low-dose tylosin exposure remain unclear.
Wenbo Li, Nengzheng Wang, Donghao Lyu, Xiaogang Yu, Xuejian He, Kan Yu, Yushu Qiu, Xianting Jiao   +7 more
doaj   +1 more source

Evaluating zuranolone: Discrepancies and insights from multiple systematic reviews and meta-analyses on major depression and postpartum depression treatment

Brain Disorders
Zuranolone, a novel neuroactive steroid and positive allosteric modulator of γ-aminobutyric acid type A (GABAA) receptors, has been explored for its potential in treating major depressive disorder (MDD) and postpartum depression (PPD).
Abdulqadir J. Nashwan, Areesha Jawed
doaj   +1 more source

Effects of prenatal stress on neuroactive steroid responses to acute stress in adult male and female rats. [PDF]

J Neuroendocrinol, 2021
Sze Y, Brunton PJ.
europepmc   +1 more source

Neurosteroid Modulation of Synaptic and Extrasynaptic GABA_A Receptors of the Mouse Nucleus Accumbens

Biomolecules
The recent approval of formulations of the endogenous neurosteroid allopregnanolone (brexanolone) and the synthetic neuroactive steroid SAGE-217 (zuranolone) to treat postpartum depression (PPD) has encouraged further research to elucidate why these ...
Scott J. Mitchell, Grant D. Phillips, Becks Tench, Yunkai Li, Delia Belelli, Stephen J. Martin, Jerome D. Swinny, Louise Kelly, John R. Atack, Michael Paradowski, Jeremy J. Lambert   +10 more
doaj   +1 more source

Neuroactive steroids and anxiety disorders

Journal of Psychiatry and Neuroscience, 2002
Jean-Michel, Le Mellédo, Glen B, Baker
openaire   +2 more sources

Preclinical characterization of zuranolone (SAGE-217), a selective neuroactive steroid GABA_A receptor positive allosteric modulator. [PDF]

Neuropharmacology, 2020
Althaus AL, Ackley MA, Belfort GM, Gee SM, Dai J, Nguyen DP, Kazdoba TM, Modgil A, Davies PA, Moss SJ, Salituro FG, Hoffmann E, Hammond RS, Robichaud AJ, Quirk MC, Doherty JJ.   +15 more
europepmc   +1 more source

Longitudinal proneuroactive and neuroactive steroid profiles in medication-free women with, without and at-risk for perinatal depression: A liquid chromatography-tandem mass spectrometry analysis. [PDF]

Psychoneuroendocrinology, 2020
Deligiannidis KM, Kroll-Desrosiers AR, Tan Y, Dubuke ML, Shaffer SA.   +4 more
europepmc   +1 more source