Results 11 to 20 of about 155 (99)

Evaluation of Neuroprotective and Neuroregenerative Potential of NeuroAiD™ II(MLC901) in a Rat Model of Kainic Acid-Induced Spinal Cord Injury. [PDF]

Mol Neurobiol
Abstract Excitotoxic damage caused by high extracellular levels of glutamate in the spinal cord results in neuronal loss and severe locomotor impairment. This study investigates the efficacy of NeuroAiD II (MLC901), an herbal formulation, in promoting nerve regeneration following spinal cord injury (SCI) induced by kainic acid (KA).
Anjum A, Yazid MD, Daud MF, Idris J, Ng AMH, Naicker AS, Ismail OHR, Athi Kumar RK, Lokanathan Y.   +8 more
europepmc   +3 more sources

NeuroAid™-II (MLC901) provides neuroprotection and enhances neuronal cell survival against kainic acid-induced excitotoxicity in vitro by activating the PI3K/AKT pathway

Future Journal of Pharmaceutical Sciences
In the twenty-first century, in vitro models of excitotoxic injury, leveraging advanced cellular and molecular technologies, offer a promising alternative to animal studies. These models provide a more precise understanding of injury mechanisms.
Anam Anjum, Muhammad Dain Yazid, Muhammad Fauzi Daud, Jalilah Idris, Angela Min Hwei Ng, Amaramalar Selvi Naicker, Ohnmar Htwe Ismail, Ramesh Kumar Athi Kumar, Yogeswaran Lokanathan   +8 more
doaj   +3 more sources

Translational Medicine in Acute Ischemic Stroke and Traumatic Brain Injury—NeuroAiD Trials, from Traditional Beliefs to Evidence-Based Therapy [PDF]

Biomolecules
Acute ischemic stroke (AIS) and traumatic brain injury (TBI) are two severe neurological events, both being major causes of death and prolonged impairment.
Narayanaswamy Venketasubramanian, Tseng Tsai Yeo, Christopher Li Hsian Chen   +2 more
doaj   +2 more sources

A double-blind, placebo-controlled, randomized, multi-centre, phase III study of MLC901 (NeuroAiDTMII) for the treatment of cognitive impairment after mild traumatic brain injury. [PDF]

PLoS One
Introduction About half of the world population will suffer from a traumatic brain injury (TBI) during their lifetime, of which about 90% of cases are mild TBI. Although up to 40% of adults with mild TBI experience persistent functional deficits, there is no proven-effective treatment to facilitate recovery after it.
Pilipenko PI, Ivanova AA, Kotsiubinskaya YV, Grigoryeva VN, Khrulev AY, Skorokhodov AV, Gavrik MM, Mkrtchan NN, Majdan M, Valkovic P, Rabarova D, Barker-Collo S, Jones K, Feigin VL.   +13 more
europepmc   +4 more sources

Mechanical scratch injury on differentiated motor neuron of NSC-34 cells as an in vitro model for evaluation of neuroregeneration potential of NeuroAiD II (MLC901). [PDF]

In Vitro Model
Anjum A, Yazid MD, Daud MF, Idris J, Ng AMH, Naicker AS, Ismail OH, Athi Kumar RK, Lokanathan Y.   +8 more
europepmc   +2 more sources

Current Status and Evaluation of Randomized Clinical Trials of Traditional Chinese Medicine in the Treatment of Cardiovascular Diseases. [PDF]

Evid Based Complement Alternat Med, 2022
Traditional Chinese medicine has long been applied to various diseases in China for a few thousand years. In recent years, its market has gradually developed from Asian countries to Western countries. At present, due to the lack of evidence‐based medicine research, the effect of traditional Chinese medicine on the prevention and treatment of ...
Guo X, Chen X, Chen J, Tan Z, Yang Y, Zhang H.   +5 more
europepmc   +2 more sources

Mitochondrial quality control in stroke: From the mechanisms to therapeutic potentials. [PDF]

J Cell Mol Med, 2022
Abstract Mitochondrial damage is a critical contributor to stroke‐induced injury, and mitochondrial quality control (MQC) is the cornerstone of restoring mitochondrial homeostasis and plays an indispensable role in alleviating pathological process of stroke.
Tian H, Chen X, Liao J, Yang T, Cheng S, Mei Z, Ge J.   +6 more
europepmc   +2 more sources

Molecular Mechanism of MLC 901 in Acute Ischemic Stroke: A Review. [PDF]

Stroke Res Treat
Ischemic stroke is the leading cause of stroke all around the world. Ischemic stroke can cause severe and irreversible damage to the brain. Brain neuroprotection is a promising treatment strategy. Moleac (MLC) 901, a traditional Chinese medicine, is one alternative adjunctive therapy that enhances neuroprotection.
Hunaifi I, Bintang AK, Tammasse J, Wahid I, Hatta M, Islam AA, Zainuddin AA, Sugianto P.   +7 more
europepmc   +2 more sources

The NeuroAiD II (MLC901) in Vascular Cognitive Impairment Study (NEURITES) [PDF]

Cerebrovascular Diseases, 2013
<b><i>Background:</i></b> A substantial proportion of patients after nondisabling stroke are cognitively impaired compared to age- and education-matched community-dwelling controls. Moreover, poststroke patients who have ‘vascular cognitive impairment no dementia' (VCIND) of moderate severity have a high risk of incident ...
Chen, Christopher L.H., Ikram, Kamran, Anqi, Qiu, Yin, Wong Tien, Venketasubramanian, Narayanaswamy, Chen, Annabel Shen-Hsing   +5 more
openaire   +4 more sources

Neuro‐HIV—New insights into pathogenesis and emerging therapeutic targets

The FASEB Journal, Volume 37, Issue 12, December 2023., 2023
HIV infection (blue circle) by definition is the key contributor to the pathogenesis of HAND with many other contributing factors greatly influencing the progression of the disease. These factors are grouped according to their common features; HAND is at the intersection of these groups (dash‐line circle).
Dmitri Sviridov, Michael Bukrinsky
wiley   +1 more source