Results 21 to 30 of about 212 (123)

Nature's magic: how natural products work hand in hand with mitochondria to treat stroke. [PDF]

Front Pharmacol
BackgroundMitochondria, as the energy factories of cells, are involved in a wide range of vital activities, including cell differentiation, signal transduction, the cell cycle, and apoptosis, while also regulating cell growth.
Cheng L, Lv S, Wei C, Li S, Liu H, Chen Y, Luo Z, Cui H.   +7 more
europepmc   +3 more sources

A Double-Blind, Placebo-Controlled, Randomized Phase II Pilot Study to Investigate the Potential Efficacy of the Traditional Chinese Medicine Neuroaid (MLC 601) in Enhancing Recovery after Stroke (TIERS)

Cerebrovascular Diseases, 2009
<i>Background and Objective:</i> Previous clinical studies have shown that Neuroaid (MLC 601) may be beneficial in post-stroke rehabilitation. Our aim was to investigate the efficacy of Neuroaid on motor recovery in ischemic stroke patients using rehabilitation endpoints in accordance with the International Conference on Harmonization/Good ...
Kong, K.H., Wee, S.K., Ng, C.Y., Chua, K., Chan, K.F., Venketasubramanian, N., Chen, C.   +6 more
openaire   +3 more sources

Neuroprotective and neuroproliferative activities of NeuroAid (MLC601, MLC901), a Chinese medicine, in vitro and in vivo.

Neuropharmacology, 2010
International audienceAlthough stroke remains a leading cause of death and adult disability, numerous recent failures in clinical stroke trials have led to some pessimism in the field.
Borsotto, M., Brau, F., Gandin, C., Heurteaux, C., Lazdunski, Michel, Lhuillier, M., Onteniente, B., Widmann, C.   +7 more
core   +4 more sources

Current Status and Evaluation of Randomized Clinical Trials of Traditional Chinese Medicine in the Treatment of Cardiovascular Diseases. [PDF]

Evid Based Complement Alternat Med, 2022
Traditional Chinese medicine has long been applied to various diseases in China for a few thousand years. In recent years, its market has gradually developed from Asian countries to Western countries. At present, due to the lack of evidence‐based medicine research, the effect of traditional Chinese medicine on the prevention and treatment of ...
Guo X, Chen X, Chen J, Tan Z, Yang Y, Zhang H.   +5 more
europepmc   +2 more sources

New Directions in Treatments Targeting Stroke Recovery. [PDF]

Stroke, 2018
Lin DJ, Finklestein SP, Cramer SC.
europepmc   +3 more sources

Mitochondrial quality control in stroke: From the mechanisms to therapeutic potentials. [PDF]

J Cell Mol Med, 2022
Abstract Mitochondrial damage is a critical contributor to stroke‐induced injury, and mitochondrial quality control (MQC) is the cornerstone of restoring mitochondrial homeostasis and plays an indispensable role in alleviating pathological process of stroke.
Tian H, Chen X, Liao J, Yang T, Cheng S, Mei Z, Ge J.   +6 more
europepmc   +2 more sources

Molecular Mechanism of MLC 901 in Acute Ischemic Stroke: A Review. [PDF]

Stroke Res Treat
Ischemic stroke is the leading cause of stroke all around the world. Ischemic stroke can cause severe and irreversible damage to the brain. Brain neuroprotection is a promising treatment strategy. Moleac (MLC) 901, a traditional Chinese medicine, is one alternative adjunctive therapy that enhances neuroprotection.
Hunaifi I, Bintang AK, Tammasse J, Wahid I, Hatta M, Islam AA, Zainuddin AA, Sugianto P.   +7 more
europepmc   +2 more sources

Traditional Chinese medicines in the management of cardiovascular diseases:A comprehensive systematic review [PDF]

, 2016
AIMS: The aim was to perform a systematic review of the efficacy of traditional Chinese medicines (TCM) in cardiovascular disease. METHODS: Electronic databases were searched up to 11 November 2015 for all randomized‐controlled trials evaluating the ...
Ferro, Albert, Layne, Kerry
core   +4 more sources

The Alzheimer’s Disease THErapy with NEuroaid II (ATHENE) Study: A Double-Blind Randomized Delayed-Start Trial to Assess the Safety and Efficacy of MLC901 (NeuroAiD™II) as an add-on Treatment to Cholinesterase Inhibitors or Memantine in Patients With Mild to Moderate Alzheimer's Disease [PDF]

, 2021
Abstract BackgroundPreclinical and clinical studies indicate a role for MLC901 (NeuroAiDTMII) in Alzheimer’s Disease (AD). We investigated its safety and efficacy as add-on therapy to standard treatment and evaluated a disease modifying effect in mild to moderate AD.MethodsMild-moderate probable AD patients by NINCDS-ADRDA criteria, stable on ...
Christopher Chen, Qingshu Liu, Rejesh Babu Moorakonda, Nagaendran Kandiah, Boon Yeow Tan, Steven Gayoles Villaraza, Jemelle Cano, Narayanaswamy Venketasubramanian   +7 more
openaire   +1 more source

Neuro‐HIV—New insights into pathogenesis and emerging therapeutic targets

The FASEB Journal, Volume 37, Issue 12, December 2023., 2023
HIV infection (blue circle) by definition is the key contributor to the pathogenesis of HAND with many other contributing factors greatly influencing the progression of the disease. These factors are grouped according to their common features; HAND is at the intersection of these groups (dash‐line circle).
Dmitri Sviridov, Michael Bukrinsky
wiley   +1 more source