Results 11 to 20 of about 212 (123)

Translational Medicine in Acute Ischemic Stroke and Traumatic Brain Injury—NeuroAiD Trials, from Traditional Beliefs to Evidence-Based Therapy [PDF]

Biomolecules
Acute ischemic stroke (AIS) and traumatic brain injury (TBI) are two severe neurological events, both being major causes of death and prolonged impairment.
Narayanaswamy Venketasubramanian, Tseng Tsai Yeo, Christopher Li Hsian Chen   +2 more
doaj   +4 more sources

Mechanical scratch injury on differentiated motor neuron of NSC-34 cells as an in vitro model for evaluation of neuroregeneration potential of NeuroAiD II (MLC901). [PDF]

In Vitro Model
Anjum A, Yazid MD, Daud MF, Idris J, Ng AMH, Naicker AS, Ismail OH, Athi Kumar RK, Lokanathan Y.   +8 more
europepmc   +4 more sources

Evaluation of Neuroprotective and Neuroregenerative Potential of NeuroAiD™ II(MLC901) in a Rat Model of Kainic Acid-Induced Spinal Cord Injury. [PDF]

Mol Neurobiol
Abstract Excitotoxic damage caused by high extracellular levels of glutamate in the spinal cord results in neuronal loss and severe locomotor impairment. This study investigates the efficacy of NeuroAiD II (MLC901), an herbal formulation, in promoting nerve regeneration following spinal cord injury (SCI) induced by kainic acid (KA).
Anjum A, Yazid MD, Daud MF, Idris J, Ng AMH, Naicker AS, Ismail OHR, Athi Kumar RK, Lokanathan Y.   +8 more
europepmc   +3 more sources

NeuroAid™-II (MLC901) provides neuroprotection and enhances neuronal cell survival against kainic acid-induced excitotoxicity in vitro by activating the PI3K/AKT pathway

Future Journal of Pharmaceutical Sciences
In the twenty-first century, in vitro models of excitotoxic injury, leveraging advanced cellular and molecular technologies, offer a promising alternative to animal studies. These models provide a more precise understanding of injury mechanisms.
Anam Anjum, Muhammad Dain Yazid, Muhammad Fauzi Daud, Jalilah Idris, Angela Min Hwei Ng, Amaramalar Selvi Naicker, Ohnmar Htwe Ismail, Ramesh Kumar Athi Kumar, Yogeswaran Lokanathan   +8 more
doaj   +3 more sources

Effect of Combined Treatment with MLC601 (NeuroAiDTM) and Rehabilitation on Post-Stroke Recovery: The CHIMES and CHIMES-E Studies. [PDF]

Cerebrovasc Dis, 2018
Background and Purpose: MLC601 has been shown in preclinical studies to enhance neurorestorative mechanisms after stroke. The aim of this post hoc analysis was to assess whether combining MLC601 and rehabilitation has an effect on improving functional ...
Suwanwela NC, Chen CLH, Lee CF, Young SH, Tay SS, Umapathi T, Lao AY, Gan HH, Baroque Ii AC, Navarro JC, Chang HM, Advincula JM, Muengtaweepongsa S, Chan BPL, Chua CL, Wijekoon N, de Silva HA, Hiyadan JHB, Wong KSL, Poungvarin N, Eow GB, Venketasubramanian N, CHIMES-E Study Investigators.   +22 more
europepmc   +2 more sources

A double-blind, placebo-controlled, randomized, multi-centre, phase III study of MLC901 (NeuroAiDTMII) for the treatment of cognitive impairment after mild traumatic brain injury. [PDF]

PLoS One
Introduction About half of the world population will suffer from a traumatic brain injury (TBI) during their lifetime, of which about 90% of cases are mild TBI. Although up to 40% of adults with mild TBI experience persistent functional deficits, there is no proven-effective treatment to facilitate recovery after it.
Pilipenko PI, Ivanova AA, Kotsiubinskaya YV, Grigoryeva VN, Khrulev AY, Skorokhodov AV, Gavrik MM, Mkrtchan NN, Majdan M, Valkovic P, Rabarova D, Barker-Collo S, Jones K, Feigin VL.   +13 more
europepmc   +4 more sources

The NeuroAiD II (MLC901) in Vascular Cognitive Impairment Study (NEURITES) [PDF]

Cerebrovascular Diseases, 2013
<b><i>Background:</i></b> A substantial proportion of patients after nondisabling stroke are cognitively impaired compared to age- and education-matched community-dwelling controls. Moreover, poststroke patients who have ‘vascular cognitive impairment no dementia' (VCIND) of moderate severity have a high risk of incident ...
Chen, Christopher L.H., Ikram, Kamran, Anqi, Qiu, Yin, Wong Tien, Venketasubramanian, Narayanaswamy, Chen, Annabel Shen-Hsing   +5 more
openaire   +7 more sources

The value of patient selection in demonstrating treatment effect in stroke recovery trials: lessons from the CHIMES study of MLC601 (NeuroAiD). [PDF]

J Evid Based Med, 2015
© 2015 Chinese Cochrane Center, West China Hospital of Sichuan University and Wiley Publishing Asia Pty Ltd. Objective: The CHIMES Study compared MLC601 to placebo in patients with ischemic stroke of intermediate severity in the preceding 72 hours.
Venketasubramanian N, Lee CF, Wong KS, Chen CL.   +3 more
europepmc   +3 more sources

The potential of MLC901 (NeuroAiD II™), a traditional Chinese medicine

Neuroscience Research Notes, 2019
Stroke, also known as cerebral ischemia, is a common neurological disease. The therapeutic potential of MLC901 (NeuroAiD II™) has been reported in clinical trials on traumatic brain injury as well as in animal and cell models. MLC901 reduced the infarction size, ischemia-induced neurological deficits and pro-inflammatory infiltration of phagocyte.
Suhua Huang, Mingxia Lin, Xiaowei Pan, Qiwen Tan, Kai-Leng Tan   +4 more
core   +4 more sources

Effectiveness of biomedical interventions on the chronic stage of traumatic brain injury: a systematic review of randomized controlled trials. [PDF]

Front Neurol
Traumatic brain injury (TBI), in any form and severity, can pose risks for developing chronic symptoms that can profoundly hinder patients’ work/academic, social, and personal lives. In the past 3 decades, a multitude of pharmacological, stimulation, and
Kawata K, Rettke DJ, Thompson C, Mannix R, Bazarian JJ, Datta D.   +5 more
europepmc   +3 more sources