Results 21 to 30 of about 155 (99)

The Alzheimer’s Disease THErapy with NEuroaid II (ATHENE) Study: A Double-Blind Randomized Delayed-Start Trial to Assess the Safety and Efficacy of MLC901 (NeuroAiD™II) as an add-on Treatment to Cholinesterase Inhibitors or Memantine in Patients With Mild to Moderate Alzheimer's Disease [PDF]

, 2021
Abstract BackgroundPreclinical and clinical studies indicate a role for MLC901 (NeuroAiDTMII) in Alzheimer’s Disease (AD). We investigated its safety and efficacy as add-on therapy to standard treatment and evaluated a disease modifying effect in mild to moderate AD.MethodsMild-moderate probable AD patients by NINCDS-ADRDA criteria, stable on ...
Christopher Chen, Qingshu Liu, Rejesh Babu Moorakonda, Nagaendran Kandiah, Boon Yeow Tan, Steven Gayoles Villaraza, Jemelle Cano, Narayanaswamy Venketasubramanian   +7 more
openaire   +1 more source

Regional Analysis of Intact and Defective HIV Proviruses in the Brain of Viremic and Virally Suppressed People with HIV

Annals of Neurology, Volume 94, Issue 4, Page 798-802, October 2023., 2023
Here, we provide the first regional analysis of intact and defective HIV reservoirs within the brain. Brain tissue from both viremic and virally suppressed people with HIV (PWH) harbored HIV pol DNA in all regions tested, with lower levels present in basal ganglia and cerebellum relative to frontal white matter.
Thomas A. Angelovich, Catherine R. Cochrane, Jingling Zhou, Carolin Tumpach, Sarah J. Byrnes, Janna Jamal Eddine, Emily Waring, Kathleen Busman‐Sahay, Claire Deleage, Trisha A. Jenkins, Anna C. Hearps, Stuart Turville, Paul R. Gorry, Sharon R. Lewin, Bruce J. Brew, Jacob D. Estes, Michael Roche, Melissa J. Churchill   +17 more
wiley   +1 more source

Retroviral b‐Zip protein (HBZ) contributes to the release of soluble and exosomal immune checkpoint molecules in the context of neuroinflammation

Journal of Extracellular Biology, Volume 2, Issue 7, July 2023., 2023
Abstract HTLV‐I‐associated myelopathy/tropical spastic paraparesis (HAM/TSP) is a chronic, progressive, neuroinflammatory demyelinating condition of the spinal cord. We have previously shown that aberrant expression and activity of immune checkpoint (ICP) molecules such as PD‐1 and PD‐L1/PD‐L2, negatively associates with the cytolytic potential of T ...
Julie Joseph, Thomas A. Premeaux, Daniel O. Pinto, Abhishek Rao, Shrobona Guha, Amanda R. Panfil, Alison J. Carey, Lishomwa C. Ndhlovu, Elke S. Bergmann‐Leitner, Pooja Jain   +9 more
wiley   +1 more source

Nanostructured Lipid Carriers for Improved Delivery of Therapeutics via the Oral Route

Journal of Nanotechnology, Volume 2023, Issue 1, 2023., 2023
Drug delivery via the oral route has always been challenging for poorly soluble drugs. Acid‐induced hydrolysis, enzymatic degradation, and poor mucosal absorbency remain the primary hiccups for effective oral delivery of medications. With the advent of nanotechnology, nanostructured lipid carriers (NLCs) have emerged as a promising delivery carrier ...
Alok Kumar Mahor, Prem Prakash Singh, Rishikesh Gupta, Peeyush Bhardwaj, Priyanka Rathore, Ankita Kishore, Rohit Goyal, Neeraj Sharma, Jyoti Verma, Jessica M. Rosenholm, Kuldeep K. Bansal, Nasrullah Jan   +11 more
wiley   +1 more source

Antiretroviral therapy restores the homeostatic state of microglia in SIV‐infected rhesus macaques

Journal of Leukocyte Biology, Volume 112, Issue 5, Page 969-981, November 2022., 2022
Graphical Abstract ScRNA‐seq of rhesus monkey microglia reveals clusters of cells in activated states in the setting of SIV infection, which is primarily reversed by suppressing viremia with combination antiretroviral therapy. Abstract Microglia and macrophages are essential for homeostatic maintenance and innate immune response in the brain.
Andrew J. Trease, Meng Niu, Brenda Morsey, Chittibabu Guda, Siddappa N. Byrareddy, Shilpa Buch, Howard S. Fox   +6 more
wiley   +1 more source

Intact HIV Proviruses Persist in the Brain Despite Viral Suppression with ART

Annals of Neurology, Volume 92, Issue 4, Page 532-544, October 2022., 2022
Objective Human immunodeficiency virus (HIV) persistence in blood and tissue reservoirs, including the brain, is a major barrier to HIV cure and possible cause of comorbid disease. However, the size and replication competent nature of the central nervous system (CNS) reservoir is unclear.
Catherine R. Cochrane, Thomas A. Angelovich, Sarah J. Byrnes, Emily Waring, Aleks C. Guanizo, Gemma S. Trollope, Jingling Zhou, Judith Vue, Lachlan Senior, Emma Wanicek, Janna Jamal Eddine, Matthew J. Gartner, Trisha A. Jenkins, Paul R. Gorry, Bruce J. Brew, Sharon R. Lewin, Jacob D. Estes, Michael Roche, Melissa J. Churchill   +18 more
wiley   +1 more source

Osteopontin/secreted phosphoprotein‐1 harnesses glial‐, immune‐, and neuronal cell ligand‐receptor interactions to sense and regulate acute and chronic neuroinflammation

Immunological Reviews, Volume 311, Issue 1, Page 224-233, October 2022., 2022
Abstract Osteopontin (OPN) also known by its official gene designation secreted phosphoprotein‐1 (SPP1) is a fascinating, multifunctional protein expressed in a number of cell types that functions not only in intercellular communication, but also in the extracellular matrix (ECM).
Ashley Yim, Christian Smith, Amanda M. Brown   +2 more
wiley   +1 more source

Coronin 1A facilitates calcium mobilization and promotes astrocyte reactivity in HIV‐1 neuropathogenesis

FASEB BioAdvances, Volume 4, Issue 4, Page 254-272, April 2022., 2022
Abstract Astrocyte reactivity, a phenomenon observed in a variety of neurodegenerative disorders, can have both beneficial and detrimental manifestations which significantly affect neuronal physiology. In neuroAIDS, reactive astrocytes have been observed to severely affect the neuronal population present in their vicinity.
Hriday Shanker Pandey, Rishabh Kapoor, Bindu, Pankaj Seth   +3 more
wiley   +1 more source

[Retracted] Multifunctional Therapeutic Approach of Nanomedicines against Inflammation in Cancer and Aging

Journal of Nanomaterials, Volume 2022, Issue 1, 2022., 2022
Cancer is a fatal disorder that affects people across the globe, yet existing therapeutics are ineffective. The development of submicrometer transport for optimizing the biodistribution of systemically provided medications is the focus of nanomedicine.
Md. Mominur Rahman, Fahadul Islam, Sadia Afsana Mim, Md. Shajib Khan, Md. Rezaul Islam, Md. Anamul Haque, Saikat Mitra, Talha Bin Emran, Abdur Rauf, Rohit Sharma   +9 more
wiley   +1 more source

Nanotechnology‐Based Strategies for Early Diagnosis of Central Nervous System Disorders

Advanced NanoBiomed Research, Volume 1, Issue 10, October 2021., 2021
Advancement of nanotechnology offers highly effective diagnostic approaches for central nervous system (CNS) diseases. Herein, valuable insights into the current status of disease markers and nanoplatform designing for applications of biosensing and bioimaging are outlined.
Sumaira Hanif, Pir Muhammad, Zheng Niu, Muhammad Ismail, Marco Morsch, Xiaoju Zhang, Mingqiang Li, Bingyang Shi   +7 more
wiley   +1 more source