Results 51 to 60 of about 345,011 (339)

Integrating Bulk-seq and Single-cell-seq Reveals Estrogen and MAPK Pathways Associating with Neuroblastoma Outcome

Cancer Control, 2023
Introduction Neuroblastoma is the most common extracranial solid tumor in children. Patients with high-risk neuroblastoma have a 5-year survival rate less than 50% after extensive treatment. Signaling pathways control cell fate decisions that dictate the
Xin Li, Yanlong Zheng, Qiao Ge, Zhenbo Dai, Dejun Zhou, Xiangdong Tian   +5 more
doaj   +1 more source

Adenovirus-mediated hPNPase(old-35) gene transfer as a therapeutic strategy for neuroblastoma [PDF]

, 2009
Current treatment options for neuroblastoma fail to eradicate the disease in the majority of high-risk patients, clearly mandating development of innovative therapeutic strategies. Gene therapy represents a promising approach for reversing the neoplastic
Ardelt, Arnold, Beck, Benito, Brodeur, Chan, Cinatl, Cinatl, D'Alessio, Hellemans, Holmes, Jasty, Kotchetkov, Lebedeva, Lebedeva, Leszczyniecka, Leszczyniecka, Maris, McConville, Michaelis, Pattyn, Pattyn, Ross, Sarkar, Sarkar, Sarkar, Sarkar, Sarkar, Sarkar, Su, Tweddle, Van Maerken, Vandesompele, Vandesompele, Vasandani, Vasandani, Youle, Young   +37 more
core   +2 more sources

Novel Therapies for Relapsed and Refractory Neuroblastoma

Children, 2018
While recent increases in our understanding of the biology of neuroblastoma have allowed for more precise risk stratification and improved outcomes for many patients, children with high-risk neuroblastoma continue to suffer from frequent disease relapse,
Peter E. Zage
doaj   +1 more source

Intermittent hypoxia effect on osteoclastogenesis stimulated by neuroblastoma cells. [PDF]

PLoS ONE, 2014
Neuroblastoma is the most common extracranial pediatric solid tumor. Intermittent hypoxia, which is characterized by cyclic periods of hypoxia and reoxygenation, has been shown to positively modulate tumor development and thereby induce tumor growth ...
Vasantha Kumar Bhaskara, Indra Mohanam, Meena Gujrati, Sanjeeva Mohanam   +3 more
doaj   +1 more source

Frizzled receptor 6 marks rare, highly tumourigenic stem-like cells in mouse and human neuroblastomas [PDF]

, 2011
Copyright © 2011 Cantilena et al. This is an open-access article distributed under the terms of the Creative Commons Attribution 3.0 License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and ...
Cantilena, S, Chayka, O, Pastorino, F, Pezzolo, A, Pistoia, V, Ponzoni, M, Sala, A   +6 more
core   +2 more sources

Pan-neuroblastoma analysis reveals age- and signature-associated driver alterations

Nature Communications, 2020
Neuroblastoma is a pediatric malignancy with heterogeneous clinical outcomes. To better understand neuroblastoma pathogenesis, here we analyze whole-genome, whole-exome and/or transcriptome data from 702 neuroblastoma samples.
Samuel W. Brady, Yanling Liu, Xiaotu Ma, A. Gout, Kohei Hagiwara, Xin Zhou, Jian Wang, Michael Macias, Xiaolong Chen, J. Easton, H. Mulder, Michael C. Rusch, Lu Wang, J. Nakitandwe, Shaohua Lei, Eric M. Davis, A. Naranjo, Cheng Cheng, J. Maris, J. Downing, N. Cheung, M. Hogarty, M. Dyer, Jinghui Zhang   +23 more
semanticscholar   +1 more source

Genetic variation associated with childhood and adult stature and risk of MYCN‐amplified neuroblastoma

Cancer Medicine, 2020
Background Neuroblastoma is the most common pediatric solid tumor. MYCN‐amplification is an important negative prognostic indicator and inherited genetic contributions to risk are incompletely understood.
Eleanor C. Semmes, Erica Shen, Jennifer L. Cohen, Chenan Zhang, Qingyi Wei, Jillian H. Hurst, Kyle M. Walsh   +6 more
doaj   +1 more source

Binimetinib inhibits MEK and is effective against neuroblastoma tumor cells with low NF1 expression. [PDF]

, 2016
BackgroundNovel therapies are needed for children with high-risk and relapsed neuroblastoma. We hypothesized that MAPK/ERK kinase (MEK) inhibition with the novel MEK1/2 inhibitor binimetinib would be effective in neuroblastoma preclinical models ...
Liu, Yin, Scorsone, Kathleen A, Woodfield, Sarah E, Zage, Peter E, Zhang, Linna   +4 more
core   +2 more sources

Transcriptional Profiling Reveals a Common Metabolic Program in High-Risk Human Neuroblastoma and Mouse Neuroblastoma Sphere-Forming Cells

Cell Reports, 2016
High-risk neuroblastoma remains one of the deadliest childhood cancers. Identification of metabolic pathways that drive or maintain high-risk neuroblastoma may open new avenues of therapeutic interventions.
Mengling Liu, Yingfeng Xia, Jane Ding, Bingwei Ye, Erhu Zhao, Jeong-Hyeon Choi, Ahmet Alptekin, Chunhong Yan, Zheng Dong, Shuang Huang, Liqun Yang, Hongjuan Cui, Yunhong Zha, Han-Fei Ding   +13 more
doaj   +1 more source

Patient-derived models: Advanced tools for precision medicine in neuroblastoma

Frontiers in Oncology, 2023
Neuroblastoma is a childhood cancer derived from the sympathetic nervous system. High-risk neuroblastoma patients have a poor overall survival and account for ~15% of childhood cancer deaths.
Kristina Aaltonen, Katarzyna Radke, Aleksandra Adamska, Alexandra Seger, Adriana Mañas, Daniel Bexell   +5 more
doaj   +1 more source