Results 51 to 60 of about 268,028 (214)

EZH2 inhibition decreases neuroblastoma proliferation and in vivo tumor growth.

PLoS ONE, 2021
Investigation of the mechanisms responsible for aggressive neuroblastoma and its poor prognosis is critical to identify novel therapeutic targets and improve survival.
Laura V Bownes, Adele P Williams, Raoud Marayati, Laura L Stafman, Hooper Markert, Colin H Quinn, Nikita Wadhwani, Jamie M Aye, Jerry E Stewart, Karina J Yoon, Elizabeth Mroczek-Musulman, Elizabeth A Beierle   +11 more
doaj   +1 more source

Patient-derived models: Advanced tools for precision medicine in neuroblastoma

Frontiers in Oncology, 2023
Neuroblastoma is a childhood cancer derived from the sympathetic nervous system. High-risk neuroblastoma patients have a poor overall survival and account for ~15% of childhood cancer deaths.
Kristina Aaltonen, Katarzyna Radke, Aleksandra Adamska, Alexandra Seger, Adriana Mañas, Daniel Bexell   +5 more
doaj   +1 more source

A Pilot Study of Relating MYCN-Gene Amplification with Neuroblastoma-Patient CT Scans [PDF]

arXiv, 2022
Neuroblastoma is one of the most common cancers in infants, and the initial diagnosis of this disease is difficult. At present, the MYCN gene amplification (MNA) status is detected by invasive pathological examination of tumor samples. This is time-consuming and may have a hidden impact on children.
arxiv  

CD44-high neural crest stem-like cells are associated with tumour aggressiveness and poor survival in neuroblastoma tumours [PDF]

, 2019
BACKGROUND: Neuroblastoma is a paediatric tumour originated from sympathoadrenal precursors and characterized by its heterogeneity and poor outcome in advanced stages.
Aguilar Morante, Diana, Cabello Laureano, Rosa, Colmenero Repiso, Ana, Gómez Muñoz, María A., Márquez Vega, Catalina, Pardal Redondo, Ricardo, Ramírez Villar, Gema, Rodríguez Prieto, Ismael, Vega Moreno, Francisco Manuel   +8 more
core   +1 more source

Transcriptional Profiling Reveals a Common Metabolic Program in High-Risk Human Neuroblastoma and Mouse Neuroblastoma Sphere-Forming Cells

Cell Reports, 2016
High-risk neuroblastoma remains one of the deadliest childhood cancers. Identification of metabolic pathways that drive or maintain high-risk neuroblastoma may open new avenues of therapeutic interventions.
Mengling Liu, Yingfeng Xia, Jane Ding, Bingwei Ye, Erhu Zhao, Jeong-Hyeon Choi, Ahmet Alptekin, Chunhong Yan, Zheng Dong, Shuang Huang, Liqun Yang, Hongjuan Cui, Yunhong Zha, Han-Fei Ding   +13 more
doaj   +1 more source

Deep neuroevolution for limited, heterogeneous data: proof-of-concept application to Neuroblastoma brain metastasis using a small virtual pooled image collection [PDF]

arXiv, 2022
Artificial intelligence (AI) in radiology has made great strides in recent years, but many hurdles remain. Overfitting and lack of generalizability represent important ongoing challenges hindering accurate and dependable clinical deployment. If AI algorithms can avoid overfitting and achieve true generalizability, they can go from the research realm to
arxiv  

Identification of lncRNAs Associated With Neuroblastoma in Cross-Sectional Databases: Potential Biomarkers

Frontiers in Molecular Neuroscience, 2019
Long non-coding RNAs (lncRNAs) have emerged as an important regulatory control in biological systems. Though the field of lncRNA has been progressing rapidly, a complete understanding of the role of lncRNAs in neuroblastoma pathogenesis is still lacking.
Bharat Prajapati, Mena Fatma, Mahar Fatima, Md Tipu Khan, Subrata Sinha, Subrata Sinha, Prahlad K. Seth   +6 more
doaj   +1 more source

Applications and prospects of targeted therapy for neuroblastoma

World Journal of Pediatric Surgery, 2020
Background Neuroblastoma is an extremely malignant tumor in children. For advanced or recurrent cases, existing treatment modalities are limited and efficacy remains disappointing.
Jing Wang, Kai Li, Wei Yao
doaj   +1 more source

Exploring the Role of Fibroblasts in Promoting Neuroblastoma Cell Migration and Invasion

Journal of Nanotheranostics
Neuroblastoma, the most common pediatric extracranial solid tumor, arises from the malignant transformation of neural crest progenitors in the peripheral nervous system.
Diana Corallo, Cristina Nardelli, Marcella Pantile, Sara Menegazzo, Alessandra Biffi, Sanja Aveic   +5 more
doaj   +1 more source

Genetic variation associated with childhood and adult stature and risk of MYCN‐amplified neuroblastoma

Cancer Medicine, 2020
Background Neuroblastoma is the most common pediatric solid tumor. MYCN‐amplification is an important negative prognostic indicator and inherited genetic contributions to risk are incompletely understood.
Eleanor C. Semmes, Erica Shen, Jennifer L. Cohen, Chenan Zhang, Qingyi Wei, Jillian H. Hurst, Kyle M. Walsh   +6 more
doaj   +1 more source