Results 41 to 50 of about 4,274 (180)

Calcium-driven regulation of voltage-sensing domains in BK channels

eLife, 2019
Allosteric interactions between the voltage-sensing domain (VSD), the Ca2+-binding sites, and the pore domain govern the mammalian Ca2+- and voltage-activated K+ (BK) channel opening.
Yenisleidy Lorenzo-Ceballos, Willy Carrasquel-Ursulaez, Karen Castillo, Osvaldo Alvarez, Ramon Latorre   +4 more
doaj   +1 more source

Building dementia‐friendly futures: A qualitative exploration of an immersive event's impact on early‐ and mid‐career professionals

Alzheimer's &Dementia: Behavior &Socioeconomics of Aging, Volume 2, Issue 3, September 2026.
Abstract INTRODUCTION Early‐ and mid‐career professionals (EMCPs) face gaps in professional development and engagement with lived experience. Walking the Talk for Dementia (WTD), an immersive global program, aims to combat stigma, increase awareness, and foster inclusion.
Belen Custodio, Maira Okada de Oliveira, Valeria Macias‐Aguinaga, Sherril Gelmon, Walter D. Dawson, Meron Abey, Florencia Altschuler, Juan Pablo Barbosa‐Carvajal, Lenisa Brandao, Maria Florencia Clarens, Jayashree Dasgupta, Madalena Liougas, Joaquin Migeot, Daniel Quesada Astorga, Prabha Shrestha, Sridhar Vaitheswaran, Sara Laureen Bartels   +16 more
wiley   +1 more source

Educación y Neurociencias

Formazione & Insegnamento, 2017
Se presentan algunos resultados recientes de las neurociencias acerca del conocimiento, el yo, la conciencia, que llevan a una nueva idea acerca de la educación. Las neurociencias ofrecen una visión evolutiva del hombre y su cerebro genética y funcionalmente: mapas neuronales, interacción entre ellos que son determinantes en la acción cognitiva.
openaire   +2 more sources

Unveiling the Functional Role of KIF21B in Microglia Inflammatory Response

Glia, Volume 74, Issue 9, September 2026.
Microglia express KIF21B in both sexes. KIF21B binds to microglia cytoskeleton; inflammation alters such interaction promoting a phagocytic state in females. In male microglia KIF21B modulates migration. ABSTRACT Microglia are brain immune cells that maintain homeostasis and respond to injury, changing cell morphology to drive inflammation, migration ...
Danny Ganchala, Alvaro Bautista‐Abad, Daniel Pinto‐Benito, Julia Simon‐Areces, Daniela Grassi, Francesco Paolo Ulloa Severino, Maria‐Angeles Arevalo   +6 more
wiley   +1 more source

APOE and genetic risk variants influence Alzheimer's disease onset in carriers of an extra copy of APP, with and without Down syndrome

Alzheimer's &Dementia, Volume 22, Issue 8, August 2026.
Abstract INTRODUCTION An extra copy of the amyloid precursor protein (APP) gene causes autosomal dominant Alzheimer's disease (AD) and AD in Down syndrome (DS), but the factors underlying variability in age at onset (AAO) remain unclear. We investigated whether sporadic AD risk variants modify AAO. METHODS We analyzed clinical and genetic data from 100
Joan Groeneveld, Danna Perlaza, Clàudia Olivé, Lou Grangeon, Niccolo Tesi, Aude Nicolas, Chenyang Jiang, Itziar de Rojas, David Wallon, Stéphane Rousseau, Marta Rovira, Diego Real de Asúa, Fernando Moldenhauer, Ruihao Mu, Kévin Cassinari, Aline Zarea, Joaquim Aumatell Escabias, Jean‐Charles Lambert, Yolande A. L. Pijnenburg, Marc Hulsman, Everard G. B. Vijverberg, Johannes Levin, Mathias Jucker, Eric McDade, Juan Fortea, Henne Holstege, Flora H. Duits, Lisa Vermunt, Maulikkumar Patel, Matthew Johnson, Alan E. Renton, Alison M. Goate, Carlos Cruchaga, Cyril Pottier, Maria Victoria Fernandez, Olivia Belbin, Gael Nicolas, Oriol Dols‐Icardo, Sven J. van der Lee, Dominantly Inherited Alzheimer Network   +39 more
wiley   +1 more source

Evaluation of the in vitro otoprotective potential of 4-aminopyridine for cisplatin-induced ototoxicity

Frontiers in Audiology and Otology
BackgroundCisplatin, an effective chemotherapy, is a cause of ototoxicity. It enters inner ear cells through Organic Cation Transporter 2 (OCT2). Recently, we identified another cochlear transporter, Multidrug and Toxin Extrusion Protein 1 (MATE1); it ...
Sofia Waissbluth, Cindel Figueroa-Cares, Cindel Figueroa-Cares, Helmuth A. Sánchez, Agustin Demetrio Martinez, Agustin Demetrio Martinez   +5 more
doaj   +1 more source

Modelos cognitivos formales: Una herramienta para la integración del conocimiento en psicología cognitiva y neurociencia cognitiva

Actualidades en Psicología, 2014
El objetivo de la presente revisión fue proponer algunas recomendaciones para aquellos psicólogos cognitivos interesados en incorporar el estudio del sistema nervioso en sus investigaciones.
Odir Rodríguez Villagra
doaj   +1 more source

NEUROCIENCIA Y ANESTESIA

Revista Médica Clínica Las Condes, 2017
RESUMEN: Uno de los focos principales de la neurociencia es entender las funciones cerebrales superiores y cómo estas son inhibidas de manera reversible por los anestésicos generales. Por ello, la comprensión del mecanismo de acción de estos fármacos, que rutinariamente se utilizan en la práctica clínica, ha permitido avanzar enormemente en entender ...
Antonello Penna S., Dr., MD, PhD, Rodrigo Gutiérrez R., Dr., MD PhD(c)   +1 more
openaire   +2 more sources

Schedule‐dependent neuroprotection by pioglitazone in a novel model of α‐synucleinopathy in rats: Integrated behavioural and histological outcomes

British Journal of Pharmacology, Volume 183, Issue 15, Page 4227-4245, August 2026.
Background and Purpose α‐Synucleinopathies are neurodegenerative disorders characterized by the aggregation and propagation of misfolded α‐synuclein. In Parkinson's disease (PD), the most common α‐synucleinopathy, the progression of motor and nonmotor deficits, and dopaminergic neuron loss, are closely linked to the spreading of misfolded α‐synuclein ...
Alberto Santiago‐Balmaseda, Marcos M. Villegas‐Rojas, Isaac Pérez‐Segura, Maricela Espino‐Cambrón, Daniel Martinez‐Fong, Luis O. Soto‐Rojas   +5 more
wiley   +1 more source

Neurociencia

, 2021
Neurociencia. Emoción y aprendizaje; es una contribución más para los maestros y maestras que aman y valoran la educación de los niños, púberes, adolescentes y jóvenes; cuyo propósito es compartir experiencias y vivencias de este emocionante camino para encontrar una verdadera educación que mejore la vida de las personas en la forma de ser, pensar ...
openaire   +1 more source