Results 141 to 150 of about 18,329 (223)
[Research advances in the pathogenesis and treatment of neurodegeneration with brain iron accumulation]. [PDF]
Zhongguo Dang Dai Er Ke Za Zhi, 2021 Wang XS, Jiang L.
europepmc +1 more source
Annals of Neurology, Volume 99, Issue 6, Page 1415-1427, June 2026.Objective The extent of neuronal loss in Parkinson's disease (PD) and the pathogenic processes underlying neuronal dysfunction and loss remain poorly understood. Here, we analyzed the expression of key molecules representing different cell death signaling pathways and their association with Lewy pathology, dopaminergic (DA) neuron loss and stage of PD ...
Yue Jing Heng +3 more
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CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.SCI induces significant upregulation of USP5 in neurons. The overexpressed USP5 stabilizes c‐MAF protein expression through its deubiquitinase activity, activating autophagy and accelerating the degradation of autophagic ferritin, thereby mediating neuronal ferroptosis. This ultimately leads to impaired functional recovery in SCI mice.
Shiyang Weng +4 more
wiley +1 more source
Mitochondrial Dysfunction, Oxidative Stress and Neuroinflammation in Neurodegeneration with Brain Iron Accumulation (NBIA). [PDF]
Antioxidants (Basel), 2020 Hinarejos I +3 more
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CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.This study reveals that 5‐hydroxytryptamine (5‐HT) synapses in the spinal cord and 5‐HT neurons in the brainstem of the SOD1‐G93A amyotrophic lateral sclerosis (ALS) mouse model are significantly altered, showing a decrease in pre‐symptomatic stages but a marked increase as the disease progresses.
Lijun Zhou +7 more
wiley +1 more source
Progress of Immunotherapies in Parkinson's Disease
CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.Parkinson's disease (PD) is caused by an immune disorder triggered by α‐synuclein, leading to a persistent neuroinflammatory cycle that drives the disease from non‐motor symptoms to the motor stage. Second, it presents active and passive immunotherapy strategies targeting α‐synuclein and their potential in slowing down the disease progression.
Yong Peng +10 more
wiley +1 more source
Iron and glutathione at the crossroad of redox metabolism in neurons
Biological Research, 2006 Neurons, as non-dividing cells, encounter a myriad of stressful conditions throughout their lifespan. In particular, there is increasing evidence that iron progressively accumulates in the brain with age and that iron-induced oxidative stress is the ...
PAULA ARACENA +3 more
doaj
Nanoparticles in Vascular Dementia: Advantages and Challenges
CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.This review highlights the dual diagnostic and therapeutic potential of nanomaterials in Vascular Dementia (VaD). By effectively crossing the blood–brain barrier, functionalized nanoparticles facilitate early diagnosis by targeting Aβ deposits and vascular lesions.
Xianxin Liu +8 more
wiley +1 more source
Palliative care in 9 children with neurodegeneration with brain iron accumulation. [PDF]
Neurol Sci, 2020 Dangel T +3 more
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CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.HIV Tat induces ferroptosis and proinflammatory activation in microglia through iron accumulation and oxidative stress. Hydrogen sulfide donor NaHS suppresses HIV Tat‐induced ferroptosis by restoring redox balance, reinforcing the SLC7A11‐GPX4 axis, and attenuating microglial inflammation, highlighting hydrogen sulfide as a potential therapeutic ...
Aitizaz Ul Ahsan +6 more
wiley +1 more source