Results 171 to 180 of about 18,329 (223)
MedComm, Volume 7, Issue 6, June 2026.This graphical abstract delineates noncanonical protein secretion systems across eukaryotes and prokaryotes. Eukaryotic UcPS covers four ER–Golgi bypass pathways, enabling rapid leaderless protein export via direct transmembrane translocation or vesicle‐mediated release.
Qiyuan Yang +8 more
wiley +1 more source
Encephalopathy: Cause, Pathogenesis, and Treatment
MedComm, Volume 7, Issue 6, June 2026.Various encephalopathies (sepsis‐associated, hepatic, hypoxic–ischemic, diabetic, uremic, toxic) have incompletely elucidated pathogenesis, which severely restricts targeted therapy development. Small molecule drugs show unique multitarget potential but face toxicity, poor blood–brain barrier penetration and unclear specificity.
Shimeng Lv +7 more
wiley +1 more source
Redox Regulation and Oxidative Stress in Health and Disease: Mechanisms and Therapeutic Targeting
MedComm – Future Medicine, Volume 5, Issue 2, June 2026.Reactive species serve crucial roles which are tightly regulated in both physiological as well as disease states. At physiological levels, these species are integral to redox signaling, while uncontrolled redox promotes disease pathology. This review examines the dysregulation of these processes.
Mohammad Hossein Azadi +2 more
wiley +1 more source
The Dual Role of Autophagy in Cancer: Mechanisms and Therapeutic Strategies
MedComm – Oncology, Volume 5, Issue 2, June 2026.Autophagy is a conserved cellular process degrading dysfunctional organelles and protein aggregates to maintain cell homeostasis, and it exhibits context‐dependent duality in cancer. Autophagy functions as a critical tumor‐suppressive mechanism by preventing DNA damage and mutation during tumor initiation.
Xiang‐Zheng Gao +4 more
wiley +1 more source
NBIA - neurodegeneration with brain iron accumulation [PDF]
Neurologie pro praxi, 2016 Lenka Hvizdošová +3 more
openaire +1 more source
Protein Science, Volume 35, Issue 6, June 2026.Abstract Alzheimer's disease (AD) is characterized by the intracellular aggregation of the microtubule‐associated protein Tau. While the presence of large, insoluble neurofibrillary tangles has long been the primary focus of this research, a paradigm shift in the field now highlights smaller, soluble oligomers as the more neurotoxic Tau species leading
Joshua T. Skrehot, Dmitry Kurouski
wiley +1 more source
AP4 deficiency: A novel form of neurodegeneration with brain iron accumulation? [PDF]
Neurol Genet, 2018 Roubertie A +15 more
europepmc +1 more source
Impaired proteasome activity and neurodegeneration with brain iron accumulation in FBXO7 defect
Altres ajuts: This work was funded by Instituto de Salud Carlos III; Ministerio de Educación, Cultura y Deporte; Spanish Foundation per Amor a l'Art (FPAA) grant ; Fundació la Marató de TV3 grants 20143130; and 20143131; Generalitat Valenciana grants OP ...
Pérez, Belén +18 more
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Pharmacology Research &Perspectives, Volume 14, Issue 3, June 2026.ABSTRACT Statins, widely prescribed for cardiovascular prevention, have emerged as potential disease‐modifying agents in neurodegenerative disorders due to their pleiotropic effects on cholesterol metabolism, neuroinflammation, oxidative stress, and protein aggregation.
Luigi Maria Chiatto +7 more
wiley +1 more source
Chemical Biology &Drug Design, Volume 107, Issue 6, June 2026.Total flavonoid intake was significantly inversely associated with neurodegenerative diseases risk. Participants in the highest quartile (Q4) of total flavonoid intake exhibited a 48% lower risk compared to those in the lowest quartile (Q1) (OR = 0.52, 95% CI: 0.31–0.90; p for trend = 0.016).
Chenzhong Zong +5 more
wiley +1 more source