Results 111 to 120 of about 9,301,430 (292)

Unveiling the power of high-dimensional cytometry data with cyCONDOR

Nature Communications
High-dimensional cytometry (HDC) is a powerful technology for studying single-cell phenotypes in complex biological systems. Although technological developments and affordability have made HDC broadly available in recent years, technological advances ...
Charlotte Kröger, Sophie Müller, Jacqueline Leidner, Theresa Kröber, Stefanie Warnat-Herresthal, Jannis Bastian Spintge, Timo Zajac, Anna Neubauer, Aleksej Frolov, Caterina Carraro, DELCODE Study Group, Frank Jessen, Simone Puccio, Anna C. Aschenbrenner, Joachim L. Schultze, Tal Pecht, Marc D. Beyer, Lorenzo Bonaguro   +17 more
doaj   +1 more source

Histone Deacetylases Inhibitors in Neurodegenerative Diseases, Neuroprotection and Neuronal Differentiation

Frontiers in Pharmacology, 2020
Histone deacetylases (HADC) are the enzymes that remove acetyl group from lysine residue of histones and non-histone proteins and regulate the process of transcription by binding to transcription factors and regulating fundamental cellular process such ...
S. Shukla, B. Tekwani
semanticscholar   +1 more source

Patient Selection in Deep Brain Stimulation: A Role for Transcranial Direct Current Stimulation to Enhance the Levodopa Challenge?

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Dopaminergic medication and deep brain stimulation (DBS) improve motor symptoms in Parkinson's disease (PD), but levodopa response alone may not predict DBS outcomes. We retrospectively analyzed 19 PD patients undergoing levodopa challenges with and without prior transcranial direct current stimulation targeting a defined PD response network ...
Lukas L. Goede, Patricia Zvarova, Bahne H. Bahners, Andreas Horn   +3 more
wiley   +1 more source

Peripheral whole blood microRNA expression in relation to vascular function: a population-based study

Journal of Translational Medicine
Background As key regulators of gene expression, microRNAs affect many cardiovascular mechanisms and have been associated with several cardiovascular diseases.
Valentina Talevi, Konstantinos Melas, Gökhan Pehlivan, Mohammed A. Imtiaz, Dennis Manfred Krüger, Tonatiuh Pena Centeno, N. Ahmad Aziz, Andre Fischer, Monique M.B. Breteler   +8 more
doaj   +1 more source

Cellular Senescence in Neurodegenerative Diseases

Frontiers in Cellular Neuroscience, 2020
Cellular senescence is a homeostatic biological process characterized by a permanent state of cell cycle arrest that can contribute to the decline of the regenerative potential and function of tissues.
C. Martínez-Cué, N. Rueda
semanticscholar   +1 more source

CSF Biomarker‐Based Cognitive Trajectories in Parkinson's Disease‐Subjective Cognitive Decline

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Cognitive complaints without objective cognitive impairment in Parkinson's Disease, termed Parkinson's Disease‐Subjective Cognitive Decline (PD‐SCD), have been associated with cognitive decline. However, its progression is heterogeneous, highlighting the need for improved identification of patients at greater risk for deterioration ...
Jon Rodriguez‐Antiguedad, Arnau Puig‐Davi, Iñigo Ruíz‐Barrio, Javier Pagonabarraga, Anna Vázquez‐Oliver, Andrea Horta‐Barba, Jaime Kulisevsky, Saül Martínez‐Horta   +7 more
wiley   +1 more source

Why regenerative stem cell medicine progresses slower than expected [PDF]

, 2014
Stem cell research has been acclaimed to revolutionize the future of medicine, and to offer new treatments for previously incurable diseases. Despite years of research, however, the therapeutic potential of stem cell research has not yet been fully ...
Amariglio, Bersenev, Collier, Earls, Feuerstein, Hay, Keating, Keirstead, Keirstead, Knowles, Ledford, Patterson, Rawlins, Rosemann, Sipp, Sleeboom-Faulkner, Wilson   +16 more
core   +1 more source

Mitophagy in Alzheimer’s Disease and Other Age-Related Neurodegenerative Diseases

Cells, 2020
Mitochondrial dysfunction is a central aspect of aging and neurodegenerative diseases, including Alzheimer’s disease, Parkinson’s disease, amyotrophic lateral sclerosis, and Huntington’s disease.
Qian Cai, Yu Young Jeong
semanticscholar   +1 more source

SARS‐CoV‐2 Is Linked to Brain Volume Loss in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The impact of SARS‐CoV‐2 infection on brain and spinal cord pathology in patients with multiple sclerosis (pwMS) remains unclear. We aimed to describe changes in brain lesion activity and brain and spinal cord volumes following SARS‐CoV‐2 infection.
Tomas Uher, Dominika Stastna, Ingrid Menkyova, Vaclav Capek, Jiri Lindner, Petra Nytrova, Jan Krasensky, Eliza Varju, Miguel D'haeseleer, Eva Kubala Havrdova, Dana Horakova, Manuela Vaneckova, Niels Bergsland   +12 more
wiley   +1 more source

Cognitive reserve against Alzheimer’s pathology is linked to brain activity during memory formation

Nature Communications
The cognitive reserve (CR) hypothesis posits that individuals can differ in how their brain function is disrupted by pathology associated with aging and neurodegeneration.
Niklas Vockert, Judith Machts, Luca Kleineidam, Aditya Nemali, Enise I. Incesoy, Jose Bernal, Hartmut Schütze, Renat Yakupov, Oliver Peters, Daria Gref, Luisa Sophie Schneider, Lukas Preis, Josef Priller, Eike Jakob Spruth, Slawek Altenstein, Anja Schneider, Klaus Fliessbach, Jens Wiltfang, Ayda Rostamzadeh, Wenzel Glanz, Stefan Teipel, Ingo Kilimann, Doreen Goerss, Christoph Laske, Matthias H. Munk, Annika Spottke, Nina Roy, Michael T. Heneka, Frederic Brosseron, Michael Wagner, Steffen Wolfsgruber, Laura Dobisch, Peter Dechent, Stefan Hetzer, Klaus Scheffler, Peter Zeidman, Yaakov Stern, Björn H. Schott, Frank Jessen, Emrah Düzel, Anne Maass, Gabriel Ziegler, the DELCODE study group   +42 more
doaj   +1 more source