Results 111 to 120 of about 241,511 (306)

Dietary Polyphenols and Their Effects on Cell Biochemistry and Pathophysiology 2014 [PDF]

, 2015
Epidemiological studies suggest that high dietary intake of phytochemicals and in particular of polyphenols is associated with decreased risk of a multitude of diseases states including cardiovascular disease, cancer, and neurodegenerative diseases.
Angeloni, Cristina, Maraldi, Tullia, Milenkovic, Dragan, Vauzour, David   +3 more
core   +5 more sources

Mitochondrial oxidant stress promotes α-synuclein aggregation and spreading in mice with mutated glucocerebrosidase

npj Parkinson's Disease
In this study, heterozygous expression of a common Parkinson-associated GBA1 variant, the L444P mutation, was found to exacerbate α-synuclein aggregation and spreading in a mouse model of Parkinson-like pathology targeting neurons of the medullary vagal ...
Pietro La Vitola, Eva M. Szegö, Rita Pinto-Costa, Angela Rollar, Eugenia Harbachova, Anthony HV Schapira, Ayse Ulusoy, Donato A. Di Monte   +7 more
doaj   +1 more source

Subjective memory impairment: No suitable criteria for case‐finding of dementia in primary care

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring, 2015
Introduction Subjective memory impairment (SMI) might be used for the case‐finding of dementia. Present analyses aim to determine the diagnostic value and the predictive ability of SMI and related worries for the discrimination of patients screened ...
Tilly Eichler, Jochen René Thyrian, Johannes Hertel, Diana Wucherer, Bernhard Michalowsky, Katinka Reiner, Adina Dreier, Ingo Kilimann, Stefan Teipel, Wolfgang Hoffmann   +9 more
doaj   +1 more source

Brain tyrosinase overexpression implicates age-dependent neuromelanin production in Parkinson’s disease pathogenesis

Nature Communications, 2019
It is unclear if neuromelanin plays a role in Parkinson’s disease pathogenesis since common laboratory animals lack this pigment. Authors show here that overexpression of human tyrosinase in the substantia nigra of rats resulted in an age-dependent ...
Iria Carballo-Carbajal, Ariadna Laguna, Jordi Romero-Giménez, Thais Cuadros, Jordi Bové, Marta Martinez-Vicente, Annabelle Parent, Marta Gonzalez-Sepulveda, Núria Peñuelas, Albert Torra, Beatriz Rodríguez-Galván, Andrea Ballabio, Takafumi Hasegawa, Analía Bortolozzi, Ellen Gelpi, Miquel Vila   +15 more
doaj   +1 more source

Calcium modulating ligand confers risk for Parkinson's disease and impacts lysosomes

Annals of Clinical and Translational Neurology, EarlyView.
Abstract Objective Several genetic loci known to confer risk for Parkinson's disease (PD) function in lysosomal pathways. We systematically screened common variants linked to PD risk by genome‐wide association studies (GWAS) for impact on cerebrospinal fluid (CSF) proteins reflecting lysosomal function.
Hanwen Zhang, Daniel Kargilis, Thomas Tropea, John Robinson, Junchao Shen, Eliza M. Brody, Ann Brinkmalm, Simon Sjödin, Adama J. Berndt, Marc Carceles‐Cordon, EunRan Suh, Vivianna M. Van Deerlin, Kaj Blennow, Daniel Weintraub, Edward B. Lee, Henrik Zetterberg, Alice S. Chen‐Plotkin   +16 more
wiley   +1 more source

Striatal dopamine neurotransmission is altered in age- and region-specific manner in a Parkinson’s disease transgenic mouse

Scientific Reports
Dopamine (DA) plays a critical role in striatal motor control. The drop in DA level within the dorsal striatum is directly associated with the appearance of motor symptoms in Parkinson’s disease (PD).
Jose Medina-Luque, Patrick Piechocinski, Paul Feyen, Carmelo Sgobio, Jochen Herms   +4 more
doaj   +1 more source

Implications for oxidative stress and astrocytes following 26S proteasomal depletion in mouse forebrain neurones [PDF]

, 2013
Neurodegenerative diseases are characterized by progressive degeneration of selective neurones in the nervous system, but the underlying mechanisms involved in neuroprotection and neurodegeneration remain unclear.
Abisambra, Ambruso, Andersen, Antunes, Aslihan Ugun-Klusek, Beal, Bedford, Beranova-Giorgianni, Bhandary, Chandra, Chatterjee, Choy, Croisier, Demasi, Dennissen, Ding, Dumitru Constantin-Teodosiu, Ebrahimi-Fakhari, Ellen Billett, Erdelmeier, Federico, Ferreiro, Fisher, Fisher, Fisher, Fisher, Freeman, Fribley, Gandhi, Goemaere, Goldberg, Grune, Hussong, Jain, Jamal Elkharaz, James Lowe, Jin, Jourdain, Kalyanaraman, Kamphuis, Karen Lawler, Kastle, Kim, Krapfenbauer, Leavey, Leuner, Lien, Ling, Lowe, Lynn Bedford, Malhotra, Manevich, Manevich, Mayford, Middeldorp, Morawe, Omura, Orre, Paine, Palacino, Pekny, Pickering, Pickering, Pimentel, Power, Power, Pratico, R John Mayer, Rabilloud, Samali, Schapira, Shringarpure, Slater, Sofroniew, Sofroniew, Strey, Tannu, Tsien, Varcin, Wang, Wang, Wang, Wang, Wang, Wang, Xiong, Yata, Zhang, Zoltewicz   +88 more
core   +1 more source

Epigenome‐wide association study, meta‐analysis, and multiscore profiling of whole blood in Parkinson's disease

Annals of Clinical and Translational Neurology, EarlyView.
Abstract Objectives An increasing body of evidence indicates altered DNA methylation in Parkinson's disease, yet the reproducibility and utility of such methylation changes are largely unexplored. We aimed to further elucidate the role of dysregulated DNA methylation in Parkinson's disease and to evaluate the biomarker potential of methylation‐based ...
Ingeborg Haugesag Lie, Manuela M. X. Tan, Maren Stolp Andersen, Mathias Toft, Lasse Pihlstrøm   +4 more
wiley   +1 more source

Unveiling the power of high-dimensional cytometry data with cyCONDOR

Nature Communications
High-dimensional cytometry (HDC) is a powerful technology for studying single-cell phenotypes in complex biological systems. Although technological developments and affordability have made HDC broadly available in recent years, technological advances ...
Charlotte Kröger, Sophie Müller, Jacqueline Leidner, Theresa Kröber, Stefanie Warnat-Herresthal, Jannis Bastian Spintge, Timo Zajac, Anna Neubauer, Aleksej Frolov, Caterina Carraro, DELCODE Study Group, Frank Jessen, Simone Puccio, Anna C. Aschenbrenner, Joachim L. Schultze, Tal Pecht, Marc D. Beyer, Lorenzo Bonaguro   +17 more
doaj   +1 more source

Relationship of cognitive decline with glucocerebrosidase activity and amyloid‐beta 42 in DLB and PD

Annals of Clinical and Translational Neurology, EarlyView.
Abstract Objective Dementia with Lewy bodies (DLB) and Parkinson's disease (PD) share clinical, pathological, and genetic risk factors, including GBA1 and APOEε4 mutations. Biomarkers associated with the pathways of these mutations, such as glucocerebrosidase enzyme (GCase) activity and amyloid‐beta 42 (Aβ42) levels, may hold potential as predictive ...
Maria Camila Gonzalez, Linn Oftedal, Johannes Lange, Diego Alejandro Tovar‐Rios, Ole‐Bjørn Tysnes, Claire Paquet, Marta Marquié, Mercè Boada, Daniel Alcolea, Konrad Rejdak, Ewa Papuc, Jakub Hort, Cristian Falup‐Pecurariu, Dag Aarsland, Guido Alves, Jodi Maple‐Grødem   +15 more
wiley   +1 more source