Results 271 to 280 of about 9,572,367 (390)

Editorial: Metabolic dysregulation in neurodegenerative diseases. [PDF]

Front Cell Neurosci
Jimenez-Gonzalez M.
europepmc   +1 more source

Bilirubin Targeting WNK1 to Alleviate NLRP3‐Mediated Neuroinflammation

Advanced Science, EarlyView.
At physiological concentrations, bilirubin binds to the kinase domain of WNK1, thereby augmenting its activity and facilitating the phosphorylation of downstream SPAK/OSR1. This phosphorylation inhibits KCC2 activity, leading to elevate intracellular chloride levels in neurons.
Linfei Mao, Jiayu Lu, Quanjun Yang, Zhenqi Liu, Cuiping Wu, Bingbing Ke, Kaiyan Su, Haolin Yuan, Yaqi Cui, Yao Wang, Richard Salvi, Guang Yang, Shankai Yin, Feng Liu, Chunyan Li   +14 more
wiley   +1 more source

Editorial: Neuroinflammation and neurodegenerative diseases. [PDF]

Front Neurosci
Kumar P, Bhaskar K.
europepmc   +1 more source

The Role of Mitochondria in Neurodegenerative Diseases: the Lesson from Alzheimer’s Disease and Parkinson’s Disease

Molecular Neurobiology, 2020
G. Monzio Compagnoni, A. Di Fonzo, S. Corti, G. Comi, N. Bresolin, E. Masliah   +5 more
semanticscholar   +1 more source

RONIN/HCF1‐TFEB Axis Protects Against D‐Galactose‐Induced Cochlear Hair Cell Senescence Through Autophagy Activation

Advanced Science, EarlyView.
D‐galactose (D‐gal) induced inner ear hair cell senescence by inhibiting TFEB transcription. RONIN/HCF1 promotes TFEB transcription to prevent cochlear HCs from D‐gal‐induced senescence through autophagy activation. Abstract Age‐related hearing loss is characterized by senescent inner ear hair cells (HCs) and reduced autophagy.
Yongjie Wei, Yuhua Zhang, Wei Cao, Nan Cheng, Yun Xiao, Yongjun Zhu, Yan Xu, Lei Zhang, Lingna Guo, Jun Song, Su‐hua Sha, Buwei Shao, Fang Ma, Jingwen Yang, Zheng Ying, Zuhong He, Renjie Chai, Qiaojun Fang, Jianming Yang   +18 more
wiley   +1 more source

Oxidative Stress: Pathological Driver in Chronic Neurodegenerative Diseases. [PDF]

Antioxidants (Basel)
Chong ZZ, Souayah N.
europepmc   +1 more source

Inflammation in Neurodegenerative Disease—A Double-Edged Sword [PDF]

, 2002
Tony Wyss‐Coray, Lennart Mucke
openalex   +1 more source

Single Administration of AAV‐mAtp6v1b2 Gene Therapy Rescues Hearing and Vestibular Disorders Caused by Atp6v1b2‐Induced Lysosomal Dysfunction in Hair Cells

Advanced Science, EarlyView.
Wei et al. establish a hair cell‐specific conditional knockout mouse model (Atp6v1b2fl/fl;Atoh1Cre/+), and demonstrate the importance of Atp6v1b2 for hair cell through maintaining the survival of lysosomes. A single administration of AAV‐ie‐Eh3‐mAtp6v1b2 through scala media at P0‐P2 realizes function compensation and restores hearing and balance ...
Gege Wei, Shiwei Qiu, Xue Gao, Lu Zheng, Yijin Chen, Ying Ma, Haifeng Feng, Jinyuan Yang, Guojie Dong, Huiyi Nie, Weihao Zhao, Xiaoge Li, Guangqin Wang, Wei Xiong, Pu Dai, Yongyi Yuan   +15 more
wiley   +1 more source

Unveiling mysteries of aging: the potential of melatonin in preventing neurodegenerative diseases in older adults. [PDF]

Biogerontology
Unal O, Akgun-Unal N, Baltaci AK.
europepmc   +1 more source

Role of Trophic Factors on Neuroimmunity in Neurodegenerative Infectious Diseases [PDF]

, 2002
Dianne Langford, Eliezer Masliah
openalex   +1 more source