Results 51 to 60 of about 9,496,868 (341)
Nature Communications, 2023 GBA1 mutations cause Gaucher’s disease and are the strongest risk factor for Parkinson’s disease. Using stable cell lines and patient iPSCs, the authors show mitochondrial localization of GBA1, which may affect neurodegenerative disease risk.
Pascale Baden +16 more
doaj +1 more source
Exploring the ATN classification system using brain morphology
Alzheimer’s Research & Therapy, 2023 Background The NIA-AA proposed amyloid-tau-neurodegeneration (ATN) as a classification system for AD biomarkers. The amyloid cascade hypothesis (ACH) implies a sequence across ATN groups that patients might undergo during transition from healthy towards ...
Nils Heinzinger +42 more
doaj +1 more source
SIRT1 and SIRT2 Activity Control in Neurodegenerative Diseases
Frontiers in Pharmacology, 2021 Sirtuins are NAD+ dependent histone deacetylases (HDAC) that play a pivotal role in neuroprotection and cellular senescence. SIRT1-7 are different homologs from sirtuins.
R. Manjula, K. Anuja, F. Alcaín
semanticscholar +1 more source
Neurofilamentopathy in Neurodegenerative Diseases [PDF]
The Open Neurology Journal, 2011 Neurofilament protein alterations are found in many neurodegenerative diseases, such as amyotrophic lateral sclerosis, Parkinson, Alzheimer, and Charcot-Marie-Tooth. Abnormal modifications of neurofilament, such as mutation, oxidation and phosphorylation, are linked to the disease-related alteration.
Liu, Quan +6 more
openaire +4 more sources
Inhibition of Stat3‐mediated astrogliosis ameliorates pathology in an Alzheimer's disease model
EMBO Molecular Medicine, 2019 Reactive astrogliosis is a hallmark of Alzheimer's disease (AD), but its role for disease initiation and progression has remained incompletely understood.
Nicole Reichenbach +7 more
doaj +1 more source
Nrf2 and Ferroptosis: A New Research Direction for Neurodegenerative Diseases
Frontiers in Neuroscience, 2020 Ferroptosis is a kind of regulated cell death (RCD) caused by the redox state disorder of intracellular microenvironment controlled by glutathione (GSH) peroxidase 4 (GPX4), which is inhibited by iron chelators and lipophilic antioxidants. In addition to
Xiaohua Song, Dingxin Long
semanticscholar +1 more source
CSPα in neurodegenerative diseases
Frontiers in Aging Neuroscience, 2022 Adult-onset neuronal ceroid lipofuscinosis (ANCL) is a rare neurodegenerative disease characterized by epilepsy, cognitive degeneration, and motor disorders caused by mutations in the DNAJC5 gene. In addition to being associated with ANCL disease, the cysteine string proteins α (CSPα) encoded by the DNAJC5 gene have been implicated in several ...
Liqin Huang, Zhaohui Zhang
openaire +3 more sources
FRET-based Tau seeding assay does not represent prion-like templated assembly of Tau filaments
Molecular Neurodegeneration, 2020 Tau aggregation into amyloid fibers based on the cross-beta structure is a hallmark of several Tauopathies, including Alzheimer Disease (AD). Trans-cellular propagation of Tau with pathological conformation has been suggested as a key disease mechanism ...
Senthilvelrajan Kaniyappan +9 more
doaj +1 more source
Astrocytes: a double-edged sword in neurodegenerative diseases
Neural Regeneration Research, 2021 Astrocytes play multifaceted and vital roles in maintaining neurophysiological function of the central nervous system by regulating homeostasis, increasing synaptic plasticity, and sustaining neuroprotective effects.
Z. Ding +5 more
semanticscholar +1 more source
Ketotherapeutics for neurodegenerative diseases
, 2020 Alzheimer's disease (AD) and Parkinson's disease (PD) are, respectively, the most prevalent and fastest growing neurodegenerative diseases worldwide. The former is primarily characterized by memory loss and the latter by the motor symptoms of tremor and bradykinesia.
Javier Gilbert Jaramillo +3 more
openaire +2 more sources