Results 51 to 60 of about 9,301,430 (292)

Neurodegeneration: Potential Causes, Prevention, and Future Treatment Options [PDF]

open access: yes, 2011
Here I advance a hypothesis that neurodegeneration is a natural process associated with aging due to the loss of genetic redundancy following a mathematical model R(t) = R0(1-αe(βC+γI+δEt)t), where the calorie intake (C) and ...
Zhongtao Zhang
core   +2 more sources

Caudo‐rostral brain spreading of α‐synuclein through vagal connections

open access: yesEMBO Molecular Medicine, 2013
α‐Synuclein accumulation and pathology in Parkinson's disease typically display a caudo‐rostral pattern of progression, involving neuronal nuclei in the medulla oblongata at the earliest stages.
Ayse Ulusoy   +6 more
doaj   +1 more source

Oxidative Stress: A Key Modulator in Neurodegenerative Diseases

open access: yesMolecules, 2019
Oxidative stress is proposed as a regulatory element in ageing and various neurological disorders. The excess of oxidants causes a reduction of antioxidants, which in turn produce an oxidation–reduction imbalance in organisms.
Anju Singh   +3 more
semanticscholar   +1 more source

FRET-based Tau seeding assay does not represent prion-like templated assembly of Tau filaments

open access: yesMolecular Neurodegeneration, 2020
Tau aggregation into amyloid fibers based on the cross-beta structure is a hallmark of several Tauopathies, including Alzheimer Disease (AD). Trans-cellular propagation of Tau with pathological conformation has been suggested as a key disease mechanism ...
Senthilvelrajan Kaniyappan   +9 more
doaj   +1 more source

Ferroptosis Mechanisms Involved in Neurodegenerative Diseases

open access: yesInternational Journal of Molecular Sciences, 2020
Ferroptosis is a type of cell death that was described less than a decade ago. It is caused by the excess of free intracellular iron that leads to lipid (hydro) peroxidation. Iron is essential as a redox metal in several physiological functions.
C. O. Reichert   +6 more
semanticscholar   +1 more source

Neurodegenerative Diseases and Autophagy [PDF]

open access: yes, 2018
Most neurodegenerative diseases are characterized by the accumulation of aggregated proteins within neurons. These aggregate-prone proteins cause toxicity, a phenomenon that is further exacerbated when there is defective protein clearance.
Aflaki   +401 more
core   +1 more source

Computational Studies of the Structural Stability of Rabbit Prion Protein Compared to Human and Mouse Prion Proteins [PDF]

open access: yes, 2011
Prion diseases are invariably fatal and highly infectious neurodegenerative diseases affecting humans and animals. The neurodegenerative diseases such as Creutzfeldt-Jakob disease, variant Creutzfeldt-Jakob diseases, Gerstmann-Str$\ddot{a}$ussler ...
Zhang, Jiapu
core   +2 more sources

The Evolving Landscape of Exosomes in Neurodegenerative Diseases: Exosomes Characteristics and a Promising Role in Early Diagnosis

open access: yesInternational Journal of Molecular Sciences, 2021
Neurodegenerative diseases (ND) remains to be one of the biggest burdens on healthcare systems and serves as a leading cause of disability and death. Alzheimer’s disease (AD) is among the most common of such disorders, followed by Parkinson’s disease (PD)
Simran Rastogi   +6 more
semanticscholar   +1 more source

Improving 3D convolutional neural network comprehensibility via interactive visualization of relevance maps: evaluation in Alzheimer’s disease

open access: yesAlzheimer’s Research & Therapy, 2021
Background Although convolutional neural networks (CNNs) achieve high diagnostic accuracy for detecting Alzheimer’s disease (AD) dementia based on magnetic resonance imaging (MRI) scans, they are not yet applied in clinical routine.
Martin Dyrba   +40 more
doaj   +1 more source

The emerging role of 5-hydroxymethylcytosine in neurodegenerative diseases [PDF]

open access: yes, 2014
Copyright © 2014 Al-Mahdawi, Anjomani Virmouni and Pook. This is an open-access article distributed under the terms of the Creative Commons Attribution License (CC BY).
Al-Mahdawi, S, Pook, MA, Virmouni, SA
core   +1 more source

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