Results 81 to 90 of about 9,496,868 (341)
Cells, 2022 Understanding changes in the expression of genes involved in regulating various components of the neural extracellular matrix (ECM) during aging can provide an insight into aging-associated decline in synaptic and cognitive functions.
David Baidoe-Ansah +8 more
doaj +1 more source
The power of microRNA regulation—insights into immunity and metabolism
FEBS Letters, EarlyView.MicroRNAs are emerging as crucial regulators at the intersection of metabolism and immunity. This review examines how miRNAs coordinate glucose and lipid metabolism while simultaneously modulating T‐cell development and immune responses. Moreover, it highlights how cutting‐edge artificial intelligence applications can identify miRNA biomarkers ...
Stefania Oliveto +2 more
wiley +1 more source
Long-term dynamics of aberrant neuronal activity in awake Alzheimer’s disease transgenic mice
Communications Biology, 2021 To advance our understanding of aberrant neuronal activity in Alzheimer’s disease (AD) Korzhova et al. use in vivo two-photon calcium imaging to record activity from cortical neurons of awake APPPS1 transgenic mice over four weeks, during the early phase
V. Korzhova +7 more
doaj +1 more source
The role of PARP1 in neurodegenerative diseases and aging
The FEBS Journal, 2021 Neurodegenerative diseases, including Alzheimer's disease (AD) and Parkinson's disease (PD), are characterized by progressive memory loss and motor impairment. Aging is a major risk factor for neurodegenerative diseases.
Kanmin Mao, Guo Zhang
semanticscholar +1 more source
Dietary Polyphenols and Their Effects on Cell Biochemistry and Pathophysiology 2014 [PDF]
, 2015 Epidemiological studies suggest that high dietary intake of phytochemicals and in particular of polyphenols is associated with decreased risk of a multitude of diseases states including cardiovascular disease, cancer, and neurodegenerative diseases.
Angeloni, Cristina +3 more
core +5 more sources
Decoding the dual role of autophagy in cancer through transcriptional and epigenetic regulation
FEBS Letters, EarlyView.Transcriptional and epigenetic regulation controls autophagy, which exerts context‐dependent effects on cancer: Autophagy suppresses tumorigenesis by maintaining cellular homeostasis or promotes tumor progression by supporting survival under stress. In this “In a Nutshell” article, we explore the intricate mechanisms of the dual function of autophagy ...
Young Suk Yu, Ik Soo Kim, Sung Hee Baek
wiley +1 more source
npj Parkinson's Disease, 2022 Mutations in the GBA gene that encodes the lysosomal enzyme β-glucocerebrosidase (GCase) are a major genetic risk factor for Parkinson’s disease (PD).
Alba Navarro-Romero +13 more
doaj +1 more source
Interneuronal In Vivo Transfer of Synaptic Proteins
Cells, 2023 Neuron-to-neuron transfer of pathogenic α-synuclein species is a mechanism of likely relevance to Parkinson’s disease development. Experimentally, interneuronal α-synuclein spreading from the low brainstem toward higher brain regions can be reproduced by
Michael Klinkenberg +6 more
doaj +1 more source
Autophagy in cancer and protein conformational disorders
FEBS Letters, EarlyView.Autophagy plays a crucial role in numerous biological processes, including protein and organelle quality control, development, immunity, and metabolism. Hence, dysregulation or mutations in autophagy‐related genes have been implicated in a wide range of human diseases.
Sergio Attanasio
wiley +1 more source
TREM2and Neurodegenerative Disease [PDF]
New England Journal of Medicine, 2013 We and other members of the Alzheimer’s Disease Genetics Consortium assembled multiple data sets from a total of 5896 black patients (1968 cases and 3928 controls). First, the association of Alzheimer’s disease with genotyped and imputed SNPs was individually assessed in each data set with the use of logistic regression for case–control data sets and ...
Rudolph E. Tanzi +2 more
openaire +11 more sources