Results 41 to 50 of about 245,709 (254)

Solid Pseudopapillary Neoplasm of the Pancreas in Children and Adolescents: Expert Recommendations

Pediatric Blood &Cancer, EarlyView.
ABSTRACT Solid pseudopapillary neoplasm of the pancreas (SPN) is a rare low‐grade malignant exocrine pancreatic tumor, mostly discovered during the second decade of life in females, with a very good prognosis, provided microscopically complete surgical excision is achieved.
Sabine Irtan, Michael Abele, Calogero Virgone, Michaela Kuhlen, Ricardo Lopez‐Almarez, Tal Ben‐Ami, Ewa Bien, Maja Cesen, Malgorzata A. Krawczyk, Andrea Ferrari, Gianni Bisogno, Yves Reguerre, Dominik T. Schneider, Louise Galmiche, Jorg Fuchs, Sarah Braungart, Bilgehan Yalcin, Ines B. Brecht, Daniel Orbach   +18 more
wiley   +1 more source

Surgical Therapy of Pancreatic Neuroendocrine Neoplasms

, 2015
Pancreatic neuroendocrine tumors are relatively rare entities, which consist of single or multiple benign or malignant neoplasms. It will be shown that in 10-20 % of patients, they can be associated with inherited syndromes, such as multiple endocrine ...
Muffatti F., Francesca Muffatti, Sara Nobile, Partelli S., Nobile S., Falconi M., Angela Maurizi, Stefano Partelli, Massimo Falconi, Maurizi A.   +9 more
core   +1 more source

Liver organoids: modelling complexity in homeostasis and disease

FEBS Letters, EarlyView.
Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley   +1 more source

Surgical Procedures for Neuroendocrine Neoplasms of the Appendix: A Consensus Guideline Review [PDF]

Journal of Biomedical & Clinical Research, 2018
According to the consensus and the recommendations of the European Neuroendocrine Tumor Society (ENETS), the frequency of appendicular neuroendocrine tumors (NETs) is 0.15-0.6/100 000 a year.
Paulina Vladova, Sergey Iliev, Savelina Popovska   +2 more
doaj   +3 more sources

The novel mTOR inhibitor RAD001 (Everolimus) induces antiproliferative effects in human pancreatic neuroendocrine tumor cells [PDF]

, 2007
Background/Aim: Tumors exhibiting constitutively activated PI(3) K/Akt/mTOR signaling are hypersensitive to mTOR inhibitors such as RAD001 (everolimus) which is presently being investigated in clinical phase II trials in various tumor entities, including
Brand, Stephan, Göke, Burkhard, Spoettl, Gerald, De Toni, Enrico N., Meyer, Heinrich H. D., Meinecke, Jennifer, Zitzmann, Kathrin, Auernhammer, Christoph J., Zitzmann, Kathrin;De Toni, Enrico N.;Brand, Stephan;Göke, Burkhard;Meinecke, Jennifer;Spöttl, Gerald;Meyer, Heinrich H.D.;Auernhammer, Christoph J.   +8 more
core   +1 more source

Epigenetic reprogramming of lineage switching in cancer

FEBS Letters, EarlyView.
Cancer cells rarely commit to a single identity. Epigenetic mechanisms and tumor microenvironment cues push epithelial cells toward flexible, hybrid states that can shift into mesenchymal, neuroendocrine, or stem‐like fates, driving metastasis, drug resistance, and tumor heterogeneity. Targeting the epigenetic regulators behind these transitions, using
Ezgi Boyvatlı, Burcu Akman, Ezgi Bağırsakçı, Nese Atabey, Serap Erkek‐Ozhan   +4 more
wiley   +1 more source

Analysis of surgical treatment of appendix neuroendocrine neoplasms—17 years of single-center experience

World Journal of Surgical Oncology, 2023
Background/aim This study investigated the clinicopathological characteristics and treatment of appendix neuroendocrine neoplasms in appendectomy specimens of our center.
He-wei Zhang, Yi Jiang, Zhi-yang Huang, Xiao-cong Zhou   +3 more
doaj   +1 more source

Surgical management for pancreatic neuroendocrine neoplasms with synchronous hepatic metastases: A literature review

Surgery in Practice and Science, 2022
Pancreatic neuroendocrine neoplasms (pNENs) are a group of heterogeneous neoplasms originating from pancreatic neuroendocrine cells. In recent years, with the development of diagnostic technology, the incidence has increased in the past decades.
Bohui Yin, Ruichen Gao, Qiang Xu, Xianze Wang, Wenming Wu   +4 more
doaj   +1 more source

The microbiome in human skin aging

FEBS Letters, EarlyView.
Age‐related skin changes encompass the well‐known visible phenotypic alterations, together with microbiome dysbiosis and a series of molecular aging hallmarks. These hallmarks characterize not only a fully stablished aged phenotype but also the skin aging process itself.
Manuel Huerta Arana, Cornelia Wiegand, Omid Omrani, Mario Fabri   +3 more
wiley   +1 more source

Metastatic niche shaped by host factors influences disseminated cancer cell fate

FEBS Letters, EarlyView.
Metastasis is shaped not only by cancer cells but also by the environments they encounter. This review explores how factors such as aging, diet, the microbiome, lifestyle, and environmental exposures remodel organ‐specific niches in the lung, liver, bone, and brain, influencing where metastatic cells survive, remain dormant, or grow, and ultimately ...
Gwennan Delyth Ward, Álvaro Ruiz‐Tabas, Patricia Altea‐Manzano   +2 more
wiley   +1 more source