Results 51 to 60 of about 245,709 (254)

Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment

Molecular Oncology, EarlyView.
This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley   +1 more source

Neuroendocrine tumors of stomach and pancreas: diagnostic potential of radiomics, issues, and solutions

Digital Diagnostics
BACKGROUND: Radiomics is currently a promising and prospective tool for diagnosing and treating neuroendocrine neoplasms at various sites. This method is often used for differential diagnosis of gastrointestinal neuroendocrine tumors with other neoplasms
Nikolay V. Nudnov, Elina S-A. Shakhvalieva, David G. Karelidze, Aleksandr A. Borisov, Mikhail E. Ivannikov   +4 more
doaj   +1 more source

Calcitonin-secreting neuroendocrine neoplasms of the lung: a systematic review and narrative synthesis

Endocrine Connections, 2021
Calcitonin-secreting neuroendocrine neoplasms of the lung are rare, with few cases reported in the literature. Differentiating between medullary th yroid carcinoma and an ectopic source of calcitonin secretion can represent a complex diagnostic conundrum
David C Llewellyn, Rajaventhan Srirajaskanthan, Royce P Vincent, Catherine Guy, Eftychia E Drakou, Simon J B Aylwin, Ashley B Grossman, John K Ramage, Georgios K Dimitriadis   +8 more
doaj   +1 more source

Neuroendocrine NeoplasmsImaging and Pathology of Pancreatic Neoplasms

, 2014
Although interest in pancreatic pathology is very high in the radiological and gastroenterological communities, it is still the case that less is known about pathology of the pancreas than about liver pathology, for example.
Matteo Fassan, D'ONOFRIO, Mirko, Paolo Tinazzi Martini, Aldo Scarpa, Crosara, Stefano, Riccardo De Robertis, SCARPA, Aldo, Roberto Pozzi Mucelli, Paola Capelli, Stefano Gobbo, Capelli, Paola, Martini, Paolo Tinazzi, DE ROBERTIS LOMBARDI, Riccardo, GOBBO, Stefano, FASSAN, MATTEO, Mirko D’Onofrio, Stefano Crosara, POZZI MUCELLI, Roberto   +17 more
core   +1 more source

KDM7A and KDM1A inhibition suppresses tumour promoting pathways in prostate cancer

Molecular Oncology, EarlyView.
Treatment resistance is a major challenge for patients with advanced prostate cancer. This study examined an alternative approach to target the major prostate cancer‐promoting pathway by targeting epigenetic factors, whose levels are higher in tumours.
Jennie N Jeyapalan, Veronika M Metzler, Simone de Brot, Corinne L Woodcock, Anna E Harris, Jennifer Lothion‐Roy, Emeli M Nilsson, Atara Ntekim, Michael S Toss, Jenny L Persson, Francesca Khani, Brian D Robinson, Lorraine J Gudas, Emad Rakha, David M Heery, Catrin S Rutland, Nigel P Mongan   +16 more
wiley   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

ENETS Consensus Guidelines for the management of patients with digestive neuroendocrine neoplasms: colorectal neuroendocrine neoplasms.

, 2012
ENETS Consensus Guidelines for the management of patients with digestive neuroendocrine neoplasms: colorectal neuroendocrine ...
O'Connor J, Baum R, Cadiot G, K. J. Klose, Grossman A, Sauvanet A, Scoazec JY, Bartsch D, Delle Fave G, Costa F, Pascher A, Brandi ML, Salazar R, Kianmanesh R, Plöckinger U, Klose KJ, Knigge U, Baudin E, Sundin A, Kelestimur F, FALCONI , MASSIMO, O. Nillson, M. Papotti, R. Salazar, Denecke T, Klöppel G, M. Caplin, Perren A, Eriksson B, F. Kelestimur, de Herder W, A. Sundin, Kwekkeboom D, Krenning E, Komminoth P, Ruszniewski P, Pavel M, Taal B, Vullierme MP, Nilsson O, Niederle B, Kos Kudla B, Arnold R, Rindi G, Tomassetti P, FALCONI, Massimo, Couvelard A, A. Pascher, Van Cutsem E, Öberg K, Jensen R, Sasano H, Caplin M, B. C. Conference Anlauf M, Wiedenmann B., U. Plöckinger, Gress T, Lopes JM, O'Toole D, Steinmüller T, Papotti M, Kaltsas G, Pape UF, Gross D, R. P. Baum   +64 more
core   +1 more source

Somatostatin receptor 4 (SSTR4) is a tumor suppressor in cutaneous and head & neck squamous cell carcinomas

Molecular Oncology, EarlyView.
This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi, Tuan Khang Huynh, Adway Kadam, Zahra Kardan, Yue Yan, Amina Jamal Laham, Sampath Kumar Loganathan   +6 more
wiley   +1 more source

Primary Laryngeal Neuroendocrine Carcinoma – A Rare Entity with Deviant Clinical Presentation [PDF]

Journal of Clinical and Diagnostic Research, 2014
Primary laryngeal neuroendocrine carcinomas are rare neoplasms. WHO classifies them under five categories of which, the moderately differentiated neuroendocrine carcinoma is synonymous with atypical or malignant carcinoid tumour.
Hemalatha A. L, Anoosha K, Amita K, Vijay Shankar S, Avadhani Geeta K   +4 more
doaj   +1 more source

Castration‐resistant prostate cancer cells are addicted to the high activity of cyclin‐dependent kinase 2

Molecular Oncology, EarlyView.
We show that emergence of castration‐resistant prostate (CRPC) is associated with significant upregulation of cyclins that positively regulate cyclin‐dependent kinase 2 (CDK2) and concomitant downregulation of CDK4 cyclins. This renders CRPC cells dependent on the high activity of CDK2, and CDK2 inhibitors synergistically sensitize CRPC cells to both ...
Joyeeta Chatterjee, Alessia Marin, Shivani Yalala, Harri M. Itkonen   +3 more
wiley   +1 more source