Results 91 to 100 of about 188,616 (304)

Treatment modalities favoring outcome in well-differentiated neuroendocrine tumors G3

Frontiers in Endocrinology
IntroductionNeuroendocrine neoplasms (NEN) are a rare and heterogenous group of tumors arising from neuroendocrine cells in multiple organs. Neuroendocrine tumors (NET) G3 encompass a small subgroup accounting for less than 10% of all neuroendocrine ...
Martina Hinterleitner, Martina Hinterleitner, Martina Hinterleitner, Ruben Pfeiffer, Nils F. Trautwein, Nils F. Trautwein, Bence Sipos, Bence Sipos, Bence Sipos, Stephan Singer, Stephan Singer, Silvio Nadalin, Silvio Nadalin, Alfred Königsrainer, Alfred Königsrainer, Ulrich M. Lauer, Ulrich M. Lauer, Ulrich M. Lauer, Ulrich M. Lauer, Christian la Fougère, Christian la Fougère, Christian la Fougère, Christian la Fougère, Lars Zender, Lars Zender, Lars Zender, Lars Zender, Clemens Hinterleitner, Clemens Hinterleitner, Clemens Hinterleitner, Clemens Hinterleitner   +30 more
doaj   +1 more source

Neuroendocrine tumors involving the gastroenteropancreatic tract: a clinicopathological evaluation of 773 cases

Clinics, 2011
OBJECTIVE: Description of some of the clinical pathological characteristics of neuroendocrine tumors of the gastroenteropancreatic tract in Brazilian patients.
Bruna Estrozi, Carlos E. Bacchi
doaj   +1 more source

Rapid, ultra low coverage copy number profiling of cell-free DNA as a precision oncology screening strategy. [PDF]

, 2017
Current cell-free DNA (cfDNA) next generation sequencing (NGS) precision oncology workflows are typically limited to targeted and/or disease-specific applications.
Alva, Ajjai S, Brockman, Scott, Chinnaiyan, Arul M, Chugh, Rashmi, Feng, Felix Y, Grasso, Catherine S, Gursky, Amy, Haakenson, Christine, Henderson, James, Herman, Kirk, Hovelson, Daniel H, Husain, Hatim, Hussain, Maha H, Kamberov, Emmanuel, Kandarpa, Malathi, Kang, Qing, Krauss, John C, Langmore, John, Liu, Chia-Jen, Lonigro, Robert J, Mills, Ryan E, Morgan, Todd M, Quist, Michael J, Ramnath, Nithya, Robinson, Dan, Smith, David C, Talpaz, Moshe, Tesmer, Tim, Tewari, Muneesh, Tomlins, Scott A, Tuck, Missy, Wang, Yugang   +31 more
core   +1 more source

Tumor‐Derived Alpha‐1 Antitrypsin Promotes Liver Metastasis of Colorectal Cancer Through the Neutrophil Extracellular Traps–CCDC25 Pathway

Advanced Science, EarlyView.
ABSTRACT Liver metastasis is a leading cause of mortality in colorectal cancer (CRC), where the inflammatory tumor microenvironment, specifically neutrophil infiltration, significantly promotes metastatic colonization. This study reveals a pro‐metastatic role for alpha‐1 antitrypsin (A1AT) in CRC liver metastasis via a dual mechanism involving ...
Qian Fei, Chunning Li, Lei Zhan, Xiaoyan Li, Yan Hui, Yue Jin, Jing Zhang, Lu Yang, Xin Sun, Xiaoxi Li, Qian Dong, Jingdong Zhang   +11 more
wiley   +1 more source

Research turns hope into reality

eLife
Two scientists describe how an acute myeloid leukemia diagnosis underscores the need for continued federal support for research and access to care.
Anna C Greene, Casey S Greene
doaj   +1 more source

Pheochromocytoma – clinical manifestations, diagnosis and current perioperative management [PDF]

, 2019
Pheochromocytoma is a neuroendocrine tumor characterized by the excessive production of catecholamines (epinephrine, norepinephrine, and dopamine). The diagnosis is suspected due to hypertensive paroxysms, associated with vegetative phenomena, due to the
Bratu, Ovidiu G, Diaconu, Camelia C, Gaman, Mihnea A, Manea, Maria, Marcu, Dragos R, Pantea Stoian, Anca, Stanescu, Ana M   +6 more
core   +2 more sources

Macrophage Extracellular Traps in Immunity and Cancer

Advanced Science, EarlyView.
As a macrophage‐mediated innate defense mechanism, the dysregulated release of METs drives chronic inflammation and influences tumor progression. Furthermore, METs exhibit a functional duality within the tumor microenvironment, capable of both promoting and suppressing tumor development.
Junyao Li, Eugenie Nepovimova, Adam Grundel, Lukas Peter, Qinghua Wu, Kamil Kuca   +5 more
wiley   +1 more source

Initial results of in vivo non-invasive cancer imaging in the human breast using near-infrared photoacoustics [PDF]

, 2007
Near-infrared photoacoustic images of regions-of-interest in 4 of the 5 cases of patients with symptomatic breasts reveal higher intensity regions which we attribute to vascular distribution associated with cancer.
Engh, Frank M. van den, Hespen, Johan C.G. van, Klaase, Joost M., Leeuwen, Ton G. van, Manohar, Srirang, Steenbergen, Wiendelt, Vaartjes, Susanne E.   +6 more
core   +3 more sources

Dysregulation of Oral Microbial Eicosapentaenoic Acid Induced by Chronic Restraint Stress Exacerbates Periodontitis via M1 Macrophage Polarization

Advanced Science, EarlyView.
ABSTRACT The intricate interplay between chronic psychological stress and periodontitis, mediated by oral microbiota and macrophage polarization, remains largely enigmatic. Here, we demonstrate that chronic restraint stress (CRS) exacerbates periodontitis by inducing oral microbial dysbiosis and a consequential shift in host metabolism.
Shihong Luo, Fangzhi Lou, Peiran Yang, Yu Zhang, Li Yan, Yunmei Dong, Bing Yang, Haiyang Wang, Yiyun Liu, Juncai Pu, Richard D. Cannon, Peng Xie, Ping Ji, Xin Jin   +13 more
wiley   +1 more source

High incidence and poor prognosis of bone metastases in functioning small intestinal neuroendocrine tumors

Frontiers in Endocrinology
BackgroundThe prevalence and clinical relevance of bone metastases (BM) in advanced small intestinal neuroendocrine tumors (siNETs) is not well-documented.MethodsWe analyzed data from 458 patients (54% male, median age 58 years) with histologically ...
Annie Mathew, Annie Mathew, Pia Hauptmeier, Pia Hauptmeier, Benedikt M. Schaarschmidt, Benedikt M. Schaarschmidt, Wolfgang P. Fendler, Wolfgang P. Fendler, Dagmar Führer, Dagmar Führer, Harald Lahner, Harald Lahner   +11 more
doaj   +1 more source