Results 101 to 110 of about 188,616 (304)

Small cell neuroendocrine carcinoma with adenocarcinoma and high grade squamous intraepithelial neoplasia of the cervix

Autopsy and Case Reports, 2023
Neuroendocrine neoplasm (NEN) of the cervix is a malignant tumor and is classified into low and intermediate-grade neuroendocrine tumor (NET), and high-grade small cell neuroendocrine carcinoma (SCNEC), and large cells neuroendocrine carcinoma (LCNEC ...
Guralarasan Gurubalan, Amber Parwaiz, Surabhi Ajit, Tarun Kumar, Madhu Kumari, Punam Bhadani   +5 more
doaj  

Extended treatment with MY-NEOVAX, personalized neoantigen-enhanced oncolytic viruses, for two end-stage cancer patients. [PDF]

, 2019
Neoantigen vaccines involving multi-peptides and poly-epitope-encoding RNA or DNA have undergone early phase clinical testing with modest reported antitumor effects [ 1].
Bouvet, Michael, Carter, Corey, Larson, Chris, Morris, John C, Oronsky, Bryan, Reid, Tony R   +5 more
core   +1 more source

Multi-Omics Analyses Detail Metabolic Reprogramming in Lipids, Carnitines, and Use of Glycolytic Intermediates between Prostate Small Cell Neuroendocrine Carcinoma and Prostate Adenocarcinoma. [PDF]

, 2019
As the most common cancer in men, prostate cancer is molecularly heterogeneous. Contributing to this heterogeneity are the poorly understood metabolic adaptations of the two main types of prostate cancer, i.e., adenocarcinoma and small cell ...
Alumkal, Joshi J, Fan, Sili, Fiehn, Oliver, Gao, Bei, Lue, Hui-Wen, Podolak, Jennifer, Serawat, Archana, Thomas, George V, Zhang, Ying   +8 more
core   +1 more source

Dynamic Shifts in ER–Plasma Membrane Junctions Signaling Define Pro‐Metastatic N‐Glycosylation and Predict Prostate Cancer Progression

Advanced Science, EarlyView.
Prostate cancer remains a leading cause of male cancer death, yet screening cannot reliably identify aggressive disease, underscoring the need for tissue biomarkers. It is shown that primary tumors increase ER–plasma membrane junction signaling via STIM1/ORP5, whereas metastasis features their loss, Golgi dispersal, and rapid conversion of high‐mannose
Amanda J. Macke, Tania Kamal, Taylor E. Divita, Artem N. Pachikov, Chad A. LaGrange, Rajesh Ravichandran, Martha Morton, Robert Powers, Haowen Qiu, Jean‐Jack M. Riethoven, Colm Morrissey, Melinda Wojtkiewicz, Rebekah L. Gundry, Carol A. Casey, Armen Petrosyan   +14 more
wiley   +1 more source

TGFBI deficiency facilitates tumor associated macrophages M2 polarization and angiogenesis to promote pancreatic neuroendocrine neoplasms progression

Cancer Cell International
Background Tumor-associated macrophages (TAMs) are key components of the tumor microenvironment (TME) that influence tumor progression through immunomodulation, angiogenesis, and extracellular matrix remodeling.
Pengfei Liu, Lin Xu, Qin Long, Fengjuan Chen, Xinyun Qiang, Xu Han, Jinxing Bao, Wei Sun, Ruitong Xu, Mujie Ye   +9 more
doaj   +1 more source

Hyperpolarized 13C-pyruvate MRI detects real-time metabolic flux in prostate cancer metastases to bone and liver: a clinical feasibility study. [PDF]

, 2020
BackgroundHyperpolarized (HP) 13C-pyruvate MRI is a stable-isotope molecular imaging modality that provides real-time assessment of the rate of metabolism through glycolytic pathways in human prostate cancer.
Aggarwal, Rahul, Bok, Robert A, Carvajal, Lucas, Chen, Hsin-Yu, Gordon, Jeremy W, Kurhanewicz, John, Larson, Peder EZ, Lee, Philip, Ohliger, Michael A, Slater, James B, Small, Eric J, van Criekinge, Mark, Vigneron, Daniel B, Zhu, Zi   +13 more
core  

Some considerations on the WHO Histological classification of laryngeal neoplasms [PDF]

, 2019
A new edition of the World Health Organization (WHO) Histological classification of tumours of the hypopharynx, larynx, trachea and parapharyngeal space was published in 2017.
Devaney, Kenneth O., Ferlito, Alfio, Hellquist, Henrik, Hunt, Jennifer L.   +3 more
core   +2 more sources

Real‐World Treatment and Outcomes in Resectable Early‐Stage Non‐Small Cell Cancer: THASSOS‐INTL Australia Cohort

AGING MEDICINE, EarlyView.
Australia cohort of THASSOS‐INTL; non‐interventional, multicenter, retrospective study provides insights into treatment patterns and associated survival outcomes in patients with resectable stage I‐III NSCLC in the pre‐immunotherapy era. Neoadjuvant and adjuvant therapy was reported in < 10% and < 40% patients, respectively.
Pei Ding, Kevin Jasas, Victoria Bray, Abhijit Pal, Rebecca Moor   +4 more
wiley   +1 more source

Preoperative Aortic Calcification Volume Predicts Postoperative Complications in Nonpancreatic Cancer Patients Undergoing Pancreaticoduodenectomy

Annals of Gastroenterological Surgery, EarlyView.
ABSTRACT Background/Objectives Postoperative complications following pancreaticoduodenectomy (PD) remain high, particularly in patients with soft pancreatic texture. Abdominal aortic calcification volume (AACV), a surrogate marker of systemic arteriosclerosis, has been associated with increased surgical risk in lower gastrointestinal procedures ...
Masaki Horiuchi, Kentaro Miyake, Kota Sahara, Jun Yamamoto, Yutaro Kikuchi, Yasuhiro Yabushita, Yu Sawada, Yuki Homma, Ryusei Matsuyama, Itaru Endo   +9 more
wiley   +1 more source

Case Report: Lorlatinib for the treatment of ALK-rearranged poorly differentiated thyroid carcinoma after progression to prior ALK-specific tyrosine-kinase inhibitor

Frontiers in Oncology
ALK rearrangements are rare but actionable oncogenic drivers in thyroid cancer, particularly in aggressive histologies such as poorly differentiated thyroid carcinoma (PDTC), and evidence supporting sequential ALK inhibition in this setting is scarce. We
Jesús Yaringaño, Jorge Hernando, Jorge Hernando, Alejandro García-Álvarez, Alejandro García-Álvarez, Carmela Iglesias-Felip, Carles Zafón, Ana Vivancos, María Roca-Herrera, Sergio Pérez-Fernández, Sergio Pérez-Fernández, Sandra Martínez-Badal, Sandra Martínez-Badal, Belén Elguero, Belén Elguero, Jaume Capdevila, Jaume Capdevila   +16 more
doaj   +1 more source