Results 101 to 110 of about 48,932 (217)

Frontotemporal neurofibrillary tangles and cerebrovascular lesions are associated with autism spectrum behaviors in late-life dementia. [PDF]

J Neurol, 2022
Rhodus EK, Barber J, Kryscio RJ, Abner EL, Bahrani AA, Lewis KES, Carey B, Nelson PT, Van Eldik LJ, Jicha GA.   +9 more
europepmc   +1 more source

Associations between TMEM106B C‐terminal fragment aggregation, age, and TDP‐43 or tau pathology

Brain Pathology, Volume 36, Issue 5, September 2026.
TMEM106B C‐terminal fragment (CTF) aggregation represents an age‐associated, common, diffuse phenomenon emerging after midlife with a weak association with TDP‐43 or tau pathology. These findings suggest that TMEM106B fibrillization may define a distinct axis of protein aggregation in the aging human brain. Abstract Transmembrane protein 106B (TMEM106B)
Albert Acewicz, Sylwia Tarka, Michał Grzegorczyk, Radosław Rzepliński, Teresa Wierzba‐Bobrowicz, Tomasz Stępień   +5 more
wiley   +1 more source

Selective In Vitro and Ex Vivo Staining of Brain Neurofibrillary Tangles and Amyloid Plaques by Novel Ethylene Ethynylene-Based Optical Sensors. [PDF]

Biosensors (Basel), 2023
Monge FA, Fanni AM, Donabedian PL, Hulse J, Maphis NM, Jiang S, Donaldson TN, Clark BJ, Whitten DG, Bhaskar K, Chi EY.   +10 more
europepmc   +1 more source

New perspectives on VEGF signalling in Alzheimer's disease

Brain Pathology, Volume 36, Issue 5, September 2026.
Emery et al. bring together findings from recent multi‐omic studies, including single‐cell mRNA analysis of human post‐mortem brain tissue, and proteomic analysis of matched CSF and blood samples in large clinical studies. The authors present evidence of the involvement of altered VEGF signalling in vascular and immune dysfunction and neurodegeneration
Cherelle E. G. Emery, Seth Love, J. Scott Miners   +2 more
wiley   +1 more source

Phenotypic Displays of Cholinergic Enzymes Associate With Markers of Inflammation, Neurofibrillary Tangles, and Neurodegeneration in Pre- and Early Symptomatic Dementia Subjects. [PDF]

Front Aging Neurosci, 2022
Teitsdottir UD, Darreh-Shori T, Lund SH, Jonsdottir MK, Snaedal J, Petersen PH.   +5 more
europepmc   +1 more source

Brain pathology in relation to somatic diseases: Exploring the body–brain crosstalk

Journal of Internal Medicine, Volume 300, Issue 3, Page 223-237, September 2026.
Abstract Several somatic diseases have been consistently linked with an increased dementia risk. However, the underlying neuropathological substrates remain poorly characterized. This narrative review aims to summarize evidence on the association between common age‐related somatic conditions (i.e., heart diseases, type 2 diabetes, kidney disease, liver
G. Grande, M. Valletta, F. Gasparini, D. L. Vetrano, M. Canevelli, J. R. Bacci, C. Qiu, A. Marengoni, M. Toccaceli Blasi, H. Xu, L. Fratiglioni, M. M. Mielke   +11 more
wiley   +1 more source

CSF p-tau increase in response to Aβ-type and Danish-type cerebral amyloidosis and in the absence of neurofibrillary tangles. [PDF]

Acta Neuropathol, 2022
Kaeser SA, Häsler LM, Lambert M, Bergmann C, Bottelbergs A, Theunis C, Mercken M, Jucker M.   +7 more
europepmc   +1 more source

Intranasal Administration of Isoeugenol Improves Memory Deficits in APP/PS1 Old Mice—A Role Beyond Nrf2 Activation?

The FASEB Journal, Volume 40, Issue 15, 15 August 2026.
Inactivation of the Nrf2/Are pathway in AD leads to decreased antioxidant and anti‐inflammatory response and to the accumulation of beta‐amyloid (Aβ) plaques, resulting in cognitive failure. Treatment with Isoeugenol activates Nrf2, reversing these outcomes by promoting antioxidant response in neuronal cells (N2a) and by increasing the anti ...
Ana Silva, Sónia Silva, Jéssica Macedo, Patrícia Moreira, Diana Baptista, Joana Bicker, Ana Fortuna, Joana Liberal, Beatriz Rodrigues, Rosa Resende, Inês Vitorino, Armanda E. Santos, Bruno Miguel Neves, Cláudia Pereira, Maria Teresa Cruz   +14 more
wiley   +1 more source

From understanding to action: Exploring molecular connections of Down syndrome to Alzheimer's disease for targeted therapeutic approach

Alzheimer’s & Dementia: Diagnosis, Assessment & Disease Monitoring
Down syndrome (DS) is caused by a third copy of chromosome 21. Alzheimer's disease (AD) is a neurodegenerative condition characterized by the deposition of amyloid‐beta (Aβ) plaques and neurofibrillary tangles in the brain.
Sonal Sukreet, Michael S. Rafii, Robert A. Rissman   +2 more
doaj   +1 more source

Tau-proximity ligation assay reveals extensive previously undetected pathology prior to neurofibrillary tangles in preclinical Alzheimer's disease. [PDF]

Acta Neuropathol Commun, 2021
Bengoa-Vergniory N, Velentza-Almpani E, Silva AM, Scott C, Vargas-Caballero M, Sastre M, Wade-Martins R, Alegre-Abarrategui J.   +7 more
europepmc   +1 more source