Results 61 to 70 of about 25,703 (229)
Targeting KRAS for cancer therapy
British Journal of Pharmacology, EarlyView.In recent years, therapeutics targeted against KRAS proto‐oncogene GTPase (KRAS)‐mutant cancers have seen significant progress. Herein we outline the biology and epidemiology of KRAS alterations at the lineage and allele levels, reviewing the clinical evidence for KRASG12C inhibition from the discovery of the recessive switch pocket to sotorasib ...
Jianlong Jia +4 more
wiley +1 more source
Clinical Genetics, EarlyView.Noonan syndrome and related conditions are caused by variants in multiple genes. We analyzed 456 Russian patients using a 23‐gene panel and found disease‐causing variants in non‐PTPN11 genes in 85 cases. NF1, SOS1, BRAF, and SHOC2 explained half of these diagnoses.
Anna Orlova +5 more
wiley +1 more source
Journal of Craniovertebral Junction and Spine, 2019 The clinical presentation of spinal or extraspinal neurofibroma is radiculopathy or myelopathy, pain, and motor weakness. Extraspinal neurofibroma presenting with acute-onset monoparesis and Horner's syndrome is very rare. We report the case of a 55-year-
Lokesh S Nehete +4 more
doaj +1 more source
PDGFD‐Rearranged Dermatofibrosarcoma Protuberans With S100 and Pan‐TRK Expression
Journal of Cutaneous Pathology, EarlyView.ABSTRACT Dermatofibrosarcoma protuberans (DFSP) is a fibroblastic malignancy characterized in most cases by COL1A1::PDGFB fusion. Rare cases exhibit alternative rearrangements involving PDGFD. Here, we describe a female patient in her third decade of life who presented with a spindle cell proliferation on the shoulder.
Venezia Podesta +4 more
wiley +1 more source
International Journal of Dermatology, EarlyView.This review provides an update on the epidemiology, pathogenesis, and clinical/histologic features of cutaneous leiomyosarcoma. Prognostic factors (e.g., depth of tumor involvement, grade, etc.) that can facilitate risk stratification are also discussed, as are treatment approaches for this rare malignancy.
Tejas P. Joshi +4 more
wiley +1 more source
Ancient Schwannoma in the Nasal Cavity—A Rare Case Report With Brief Literature Review
Eye &ENT Research, EarlyView.
Shikhar Chohan +2 more
wiley +1 more source
BMC Surgery, 2021 Background Neurofibromatosis type 1 (NF1) is an autosomal dominant condition with a high rate of new mutation and variable expression. Diffuse neurofibroma of the epidermis invading deeper organs is rare.We report a case of diffuse subcutaneous ...
Xian-shuai Li +2 more
doaj +1 more source
Periodontal Disease and Salivary Gland Dysfunction in Neurofibromatosis Type 1: A Case–Control Study
Oral Diseases, EarlyView.ABSTRACT Objectives Neurofibromatosis type 1 (NF1) presents with diverse systemic and oral manifestations. The aim of this study was to investigate the periodontal status and salivary alterations in NF1 individuals. Methods A total of 38 individuals with NF1 diagnostic criteria were compared with a control group paired by age and sex.
Eloá Borges Luna +6 more
wiley +1 more source
BMJ Case Reports, 2011 Tumours of neurogenic origin are rare in parotid gland. The authors are presenting here a case of neurofibroma in a 40-year-male who presented with slow growing tumour in preauricular region of 1 year duration.
Veena, Maheshwari +6 more
openaire +2 more sources
Intraosseous neurofibroma in a 13-year-old male patient: A case report with review of literature
Journal of Cancer Research and Therapeutics, 2018 Neurofibroma is a benign tumor of nerve tissue origin, derived from the cells that constitute the nerve sheath. It is commonly found in soft tissues, but the intraosseous occurrence of solitary neurofibroma in the head and neck is comparatively rare ...
A. Iqbal +3 more
semanticscholar +1 more source