Results 31 to 40 of about 102,686 (380)

Characterization of immune response to neurofilament light in experimental autoimmune encephalomyelitis [PDF]

, 2013
PMCID: PMC3856490This is an Open Access article distributed under the terms of the Creative Commons Attribution License (http://creativecommons.org/licenses/by/2.0), which permits unrestricted use, distribution, and reproduction in any medium, provided ...
Amor, S, Baker, D, Beyer, C, Gerritsen, W, Huizinga, R, Kipp, M, Peferoen-Baert, R, Pryce, G, Puentes, F, Reijerkerk, A, Ummenthum, K, van der Star, BJ, van der Valk, P, Victor, M   +13 more
core   +5 more sources

Neurofilament Light Chain as Biomarker for Amyotrophic Lateral Sclerosis and Frontotemporal Dementia

Frontiers in Neuroscience, 2021
Amyotrophic lateral sclerosis (ALS) and frontotemporal dementia (FTD) are two related currently incurable neurodegenerative diseases. ALS is characterized by degeneration of upper and lower motor neurons causing relentless paralysis of voluntary muscles,
F. Verde, M. Otto, V. Silani
semanticscholar   +1 more source

Diagnostic Value of Cerebrospinal Fluid Neurofilament Light Protein in Neurology: A Systematic Review and Meta-analysis.

JAMA Neurology, 2019
Importance Neurofilament light protein (NfL) is elevated in cerebrospinal fluid (CSF) of a number of neurological conditions compared with healthy controls (HC) and is a candidate biomarker for neuroaxonal damage.
C. Bridel, W. V. van Wieringen, H. Zetterberg, B. Tijms, C. Teunissen, J. Álvarez-cermeño, U. Andreasson, M. Axelsson, David Bäckström, A. Bartoš, M. Bjerke, K. Blennow, A. Boxer, L. Brundin, J. Burman, T. Christensen, L. Fialová, L. Forsgren, J. Frederiksen, M. Gisslén, E. Gray, M. Gunnarsson, S. Hall, O. Hansson, M. Herbert, J. Jakobsson, Jan Jessen-Krut, S. Janelidze, G. Johannsson, M. Jonsson, L. Kappos, M. Khademi, M. Khalil, J. Kuhle, M. Landén, V. Leinonen, G. Logroscino, Ching-Hua Lu, J. Lycke, N. Magdalinou, A. Malaspina, N. Mattsson, L. Meeter, S. Mehta, S. Modvig, T. Olsson, R. Paterson, Josué Pérez-Santiago, F. Piehl, Y. Pijnenburg, Okko T. Pyykkö, O. Ragnarsson, J. Rojas, J. Romme Christensen, L. Sandberg, Carole S. Scherling, J. Schott, F. Sellebjerg, I. Simone, Tobias Skillbäck, Morten Stilund, P. Sundström, A. Svenningsson, R. Tortelli, C. Tortorella, A. Trentini, M. Troiano, M. Turner, J. V. van Swieten, Mattias Vågberg, M. Verbeek, L. Villar, P. Visser, A. Wallin, A. Weiss, C. Wikkelsø, E. Wild   +76 more
semanticscholar   +1 more source

Early Acquisition of Neural Crest Competence During hESCs Neuralization [PDF]

, 2010
Background: Neural crest stem cells (NCSCs) are a transient multipotent embryonic cell population that represents a defining characteristic of vertebrates.
Bronner-Fraser, Marianne, Cattarossi, Giulio, Cimadamore, Flavio, Curchoe, Carol Lynn, Maurer, Jochen, McKeown, Sonja J., Nilbratt, Mats, Snyder, Evan Y., Terskikh, Alexey V.   +8 more
core   +8 more sources

Association Between Longitudinal Plasma Neurofilament Light and Neurodegeneration in Patients With Alzheimer Disease.

JAMA Neurology, 2019
Importance Plasma neurofilament light (NfL) has been suggested as a noninvasive biomarker to monitor neurodegeneration in Alzheimer disease (AD), but studies are lacking.
N. Mattsson, N. Cullen, U. Andreasson, H. Zetterberg, K. Blennow   +4 more
semanticscholar   +1 more source

The Evolution of Neurofilament Light Chain in Multiple Sclerosis

Frontiers in Neuroscience, 2021
Multiple sclerosis (MS) is an autoimmune, inflammatory neurodegenerative disease of the central nervous system characterized by demyelination and axonal damage.
Carolina Ferreira‐Atuesta, Saúl Reyes, G. Giovanonni, S. Gnanapavan   +3 more
semanticscholar   +1 more source

Extra Axonal Neurofilaments Do Not Exacerbate Disease Caused by Mutant Cu,Zn Superoxide Dismutase

Neurobiology of Disease, 2000
A recent report by T. L. Williamson et al. (1998, Proc. Natl. Acad. Sci. USA 95, 9631–9636) showed that disease caused by expression of mutant Cu,Zn superoxide dismutase (SOD1) in mice was slowed down by disruption of the neurofilament light (NF-L) gene.
Sébastien Couillard-Després, Jürgen Meier, Jean-Pierre Julien   +2 more
doaj   +1 more source

C1q-targeted inhibition of the classical complement pathway prevents injury in a novel mouse model of acute motor axonal neuropathy [PDF]

, 2016
Introduction Guillain-Barré syndrome (GBS) is an autoimmune disease that results in acute paralysis through inflammatory attack on peripheral nerves, and currently has limited, non-specific treatment options.
Barrie, Jennifer A., Cunningham, Madeleine E., Fewou, Simon N., Furukawa, Koichi, McGonigal, Rhona, Sankaranarayanan, Sethu, Willison, Hugh J., Yao, Denggao, Yednock, Ted A.   +8 more
core   +2 more sources

Neurofilament light levels predict clinical progression and death in multiple system atrophy

Brain : a journal of neurology, 2022
Disease-modifying treatments are currently being trialled in multiple system atrophy. Approaches based solely on clinical measures are challenged by heterogeneity of phenotype and pathogenic complexity. Neurofilament light chain protein has been explored
V. Chelban, E. Nikram, A. Pérez-Soriano, C. Wilke, A. Foubert-Samier, N. Vijiaratnam, Tong Guo, E. Jabbari, Simisola Olufodun, Marina Gonzalez, Konstantin Senkevich, B. Laurens, P. Péran, O. Rascol, Anne Pavy Le Traon, E. Todd, Alyssa A. Costantini, Sondos Alikhwan, Ambreen Tariq, Bai Lin Ng, E. Muñoz, C. Painous, Y. Compta, C. Junqué, B. Segura, Kristina Zhelcheska, Henny Wellington, L. Schöls, Z. Jaunmuktane, C. Kobylecki, A. Church, M. Hu, J. Rowe, P. Leigh, L. Massey, D. Burn, N. Pavese, T. Foltynie, S. Pchelina, N. Wood, A. Heslegrave, Henrik Zetterberg, M. Bocchetta, J. Rohrer, M. Marti, M. Synofzik, H. Morris, W. Meissner, H. Houlden   +48 more
semanticscholar   +1 more source

Immunofluorescence characterization of innervation and nerve-immune cell interactions in mouse lymph nodes

European Journal of Histochemistry, 2019
The peripheral nervous system communicates specifically with the immune system via local interactions. These interactions include the “hardwiring” of sympathetic/parasympathetic (efferent) and sensory nerves (afferent) to primary (e.g., thymus and bone ...
Dailun Hu, Philip K. Nicholls, Melissa Claus, Yongkang Wu, Zhongli Shi, Wayne K. Greene, Bin Ma   +6 more
doaj   +1 more source