Results 41 to 50 of about 102,686 (380)
Molecular biomarkers in multiple sclerosis [PDF]
Arhiv za farmaciju, 2022 Multiple sclerosis (MS) is a highly heterogenous disease regarding radiological, pathological, and clinical characteristics and therapeutic response, including both the efficacy and safety profile of treatments.
Michaličková Danica +4 more
doaj +1 more source
Neurofilaments at a glance [PDF]
Journal of Cell Science, 2012 Neurofilaments (NFs) are intermediate filaments with a diameter of 10 nm, similar to that of neurons. Although they are present in perikarya and dendrites, neurofilaments are particularly abundant in axons, where they are essential for the radial growth of axons during development, the ...
Aidong, Yuan +3 more
openaire +2 more sources
Serum Neurofilament light: A biomarker of neuronal damage in multiple sclerosis
Annals of Neurology, 2017 Neurofilament light chains (NfL) are unique to neuronal cells, are shed to the cerebrospinal fluid (CSF), and are detectable at low concentrations in peripheral blood. Various diseases causing neuronal damage have resulted in elevated CSF concentrations.
G. Disanto +33 more
semanticscholar +1 more source
Blood neurofilament light: a critical review of its application to neurologic disease
Annals of Clinical and Translational Neurology, 2020 Neuronal injury is a universal event that occurs in disease processes that affect both the central and peripheral nervous systems. A blood biomarker linked to neuronal injury would provide a critical measure to understand and treat neurologic diseases ...
Christian Barro, T. Chitnis, H. Weiner
semanticscholar +1 more source
How the projection domains of NF-L and alpha-internexin determine the conformations of NF-M and NF-H in neurofilaments [PDF]
, 2010 Making use of a numerical self-consistent field method and polymer brush concepts, we model the solvated corona of neurofilaments (NF) composed of projection domains (unstructured tails) of constituent proteins.
Leermakers, F.A.M., Zhulina, E.B.
core +2 more sources
Blood neurofilament light chain as a biomarker of MS disease activity and treatment response
Neurology, 2019 Objective To assess the value of blood neurofilament light chain (NfL) as a biomarker of recent, ongoing, and future disease activity and tissue damage and its utility to monitor treatment response in relapsing-remitting multiple sclerosis.
J. Kuhle +9 more
semanticscholar +1 more source
Frontiers in Cell and Developmental Biology, 2022 Neurofilament light (NFL) is one of the proteins forming multimeric neuron-specific intermediate filaments, neurofilaments, which fill the axonal cytoplasm, establish caliber growth, and provide structural support.
M. Sainio +14 more
semanticscholar +1 more source
Serum Neurofilament Light Chain Levels in Patients With Presymptomatic Multiple Sclerosis.
JAMA Neurology, 2020 Importance Unrecognized demyelinating events often precede the clinical onset of multiple sclerosis (MS). Identification of these events at the time of occurrence would have implications for early diagnosis and the search of causal factors for the ...
K. Bjørnevik +8 more
semanticscholar +1 more source
Confounding effect of blood volume and body mass index on blood neurofilament light chain levels
Annals of Clinical and Translational Neurology, 2020 Blood Neurofilament light chain (NfL) has been suggested as a promising biomarker in several neurological conditions. Since blood NfL is the consequence of leaked NfL from the cerebrospinal fluid, differences in individuals’ Body Mass Index (BMI) or ...
A. Manouchehrinia +6 more
semanticscholar +1 more source
Deciphering Multiple Sclerosis Progression
Frontiers in Neurology, 2021 Multiple sclerosis (MS) is primarily an inflammatory and degenerative disease of the central nervous system, triggered by unknown environmental factors in patients with predisposing genetic risk profiles.
Virginia Meca-Lallana +11 more
doaj +1 more source