Looking for the origins of axons
eLife, 2022 Pyramidal neurons with axons that exit from dendrites rather than the cell body itself are relatively common in non-primates, but rare in monkeys and humans.
Kathleen S Rockland
doaj +1 more source
The new Global Multiple Sclerosis Severity Score (MSSS) correlates with axonal but not glial biomarkers [PDF]
, 2006 This study investigated whether the new Global Multiple Sclerosis Severity Scale (MSSS) correlated with cerebrospinal fluid biomarkers for axonal and glial pathology.
Eikelenboom, M.J. +6 more
core +1 more source
Comparison of SimoaTM and EllaTM to assess serum neurofilament‐light chain in multiple sclerosis
Annals of Clinical and Translational Neurology, 2021 We compared SimoaTM and EllaTM immunoassays to assess serum neurofilament‐light chain levels in 203 multiple sclerosis patients from the OFSEP HD study. There was a strong correlation (ρ = 0.86, p < 0.0001) between both platforms.
Audrey Gauthier +22 more
semanticscholar +1 more source
Expression of the cellular prion protein by mast cells in the human carotid body
Prion, 2023 Prion diseases are fatal neurologic disorders that can be transmitted by blood transfusion. The route for neuroinvasion following exposure to infected blood is not known.
Gregory D. Sweetland +4 more
doaj +1 more source
Abnormal white matter tracts resembling pencil fibers involving prefrontal cortex (Brodmann area 47) in autism: a case report. [PDF]
, 2016 BackgroundAutism is not correlated with any neuropathological hallmark as the brain of autistic individuals lack defined lesions. However, previous investigations have reported cortical heterotopias and local distortion of the cytoarchitecture of the ...
Ariza, Jeanelle +4 more
core +1 more source
Association of Plasma Neurofilament Light With Neurodegeneration in Patients With Alzheimer Disease
JAMA Neurology, 2017 Importance Existing cerebrospinal fluid (CSF) or imaging (tau positron emission tomography) biomarkers for Alzheimer disease (AD) are invasive or expensive.
N. Mattsson +3 more
semanticscholar +1 more source
Renal function is associated with blood neurofilament light chain level in older adults
Scientific Reports, 2020 Neurofilament light chain (NfL) is a novel biomarker of neurodegenerative diseases. It is detectable in the peripheral blood, allowing low-invasive assessment of early signs of neurodegeneration.
S. Akamine +16 more
semanticscholar +1 more source
Circulating Biomarkers in Neuromuscular Disorders: What Is Known, What Is New
Biomolecules, 2021 The urgent need for new therapies for some devastating neuromuscular diseases (NMDs), such as Duchenne muscular dystrophy or amyotrophic lateral sclerosis, has led to an intense search for new potential biomarkers.
Andrea Barp +4 more
doaj +1 more source
Chronic thoracic hemisection spinal cord injury in adult rats induces a progressive decline in transmission from uninjured fibers to lumbar motoneurons [PDF]
, 2008 Although most spinal cord injuries are anatomically incomplete, only limited functional recovery has been observed in people and rats with partial lesions.
Arko Ghosh +10 more
core +2 more sources
Neurofilament heavy chain side arm phosphorylation regulates axonal transport of neurofilaments [PDF]
The Journal of Cell Biology, 2003 Neurofilaments possess side arms that comprise the carboxy-terminal domains of neurofilament middle and heavy chains (NFM and NFH); that of NFH is heavily phosphorylated in axons. Here, we demonstrate that phosphorylation of NFH side arms is a mechanism for regulating transport of neurofilaments through axons. Mutants in which known NFH phosphorylation
Ackerley, S +7 more
openaire +3 more sources