Results 191 to 200 of about 174,681 (296)

Use of the PROMIS and Neuro‐QoL to Evaluate Health‐Related Quality of Life following Unilateral Subthalamic Deep Brain Stimulation for Parkinson's Disease

Movement Disorders Clinical Practice, EarlyView.
Abstract Background Subthalamic nucleus deep brain stimulation (STN DBS) improves Parkinson's disease (PD)‐related motor symptoms, but how STN DBS impacts various aspects of patient‐perceived health‐related quality of life (HRQoL) is less clear. The Patient‐Reported Outcome Measurement Instrument (PROMIS) and Quality of Life in Neurological Disorders ...
Sarah A. Brinkerhoff, Frank Robinson, Roy C. Martin, Sandra Morales, Christopher L. Gonzalez, Christopher P. Hurt, Melissa Wade, Gary Cutter, Gitendra Uswatte, Harrison C. Walker, Victor A. Del Bene   +10 more
wiley   +1 more source

Physical activity stimulates neurogenesis via sensory neuron activity in postembryonic zebrafish. [PDF]

iScience
Sherlock S, Appel L, Hall Z, Phan A.
europepmc   +1 more source

Recent Advances in Exosome‐Based Nanodelivery Systems for Traumatic Brain Injury Treatment

Med Research, EarlyView.
An overview of functional modification, therapeutic effects, molecular composition, and delivery strategies for exosomes. ABSTRACT Traumatic brain injury (TBI) is a highly heterogeneous neurological condition with extremely high rates of mortality and disability.
Jue Zhu, Weiquan Liao, Ziqi Lian, Mengdan Zhang, Chenxing Wang, Xingjia Zhu, Lin Zhang, Jian Chen, Zhichao Lu, Peipei Gong   +9 more
wiley   +1 more source

Immature Neurons in the Postnatal Brain: Markers, Modulation, and Involvement in Normal and Aberrant Plasticity. [PDF]

Int J Mol Sci
Riga V, Aniol V, Gulyaeva N.
europepmc   +1 more source

Integrative Multi‐Omics Analysis Reveals Convergent Epigenome and Transcriptome Changes in Parkinson's Disease

Movement Disorders, EarlyView.
Abstract Background The mechanisms that predispose dopaminergic neurons (DAN) to degeneration in Parkinson's disease (PD) are incompletely understood. Objective To perform an integrative multi‐omics reanalysis of single‐cell transcriptomic and epigenomic data to identify convergent alterations predisposing dopaminergic neurons to degeneration in ...
Mirco Macchi, Aurélien Ginolhac, Tony Heurtaux, Borja Gomez‐Ramos, Lasse Sinkkonen, Enrico Glaab, on behalf of the NCER‐PD Consortium, Mariella Graziano, Alexandre Bisdorff, Rene Dondelinger, Elodie Thiry, Gelani Zelimkhanov, Guy Berchem, Liliana Vilas Boas, Linda Hansen, Martine Goergen, Nancy De Bremaeker, Nico Diederich, Romain Nati, Roxane Batutu, Sylvia Herbrink, Jochen Klucken, Rejko Krüger, Claire Pauly, Lukas Pavelka, Marijus Giraitis, Maria Fernanda Niño Uribe, Achilleas Pexaras, Alexander Hundt, Alexia Mendibide, Ana Festas Lopes, Angelo Ferrari, Brian Dewitt, Carlos Gamio, Estelle Henry, Gaël Hamot, Geeta Acharya, Hermann Thien, Ilsé Richard, Johanna Trouet, Kate Sokolowska, Katy Beaumont, Laura Georges, Lorieza Castillo, Lucie Remark, Maeva Munsch, Margaux Henry, Maud Theresine, Olga Kofanova, Olivia Roland, Pauline Lambert, Saïda Mtimet, Wim Ammerlaan, Anne Grünewald, Armin Rauschenberger, Clarissa P.C. Gomes, Dheeraj Reddy Bobbili, Ekaterina Soboleva, Elisa Gómez de Lope, Enrico Glaab, Evi Wollscheid‐Lengeling, Francoise Meisch, Giuseppe Arena, Ibrahim Boussaad, Iñigo Yoldi Bergua, Jens Schwamborn, Kirsten Roomp, Laure Pauly, Michael T. Heneka, Michele Bassis, Muhammad Ali, Jade Jaber, Patricia Martins Conde, Patrick May, Paul Wilmes, Piotr Gawron, Rebecca Ting Jiin Loo, Reinhard Schneider, Ruxandra Soare, Sabine Schmitz, Sarah Nickels, Sascha Herzinger, Sinthuja Pachchek, Soumyabrata Ghosh, Stefano Sapienza, Valentin Groues, Venkata Satagopam, Isabel Schwaninger, Liyousew Borga, Sijmen Van Schagen, Gabriel Martinez Tirado, Alan Castro Mejia, Messaline Fomo, Niloofar Kheradbin, Francesca Boschi, Francesca Terranova, Jochen Ohnmacht, Anne‐Marie Hanff, Carlos Vega, Chouaib Mediouni, Deborah Mcintyre, Eduardo Rosales, Fozia Noor, Gessica Contesotto, Gloria Aguayo, Guilherme Marques, Jérôme Graas, Joëlle Fritz, Magali Perquin, Manon Gantenbein, Maura Minelli, Michel Vaillant, Myriam Alexandre, Myriam Menster, Olena Tsurkalenko, Raquel Severino, Sibylle Béchet, Tainá M. Marques, Ulf Nehrbass, Victoria Lorentz, Zied Landoulsi, Sonja Jónsdóttir, David Bouvier, Katrin Frauenknecht, Michel Mittelbronn, Roseline Lentz, Jean‐Paul Nicolay, Nadine Jacoby   +127 more
wiley   +1 more source

Favorable outcome of engraftment of custom designed RADA16-I based hydrogels functionalized with SDF1 or IL4 mimicking peptides to injured or dystrophic muscles. [PDF]

Sci Rep
Ostaszewska A, Michalska Z, Dzierżyńska M, Grabowska I, Zimowska M, Fularczyk M, Łukaszewicz J, Panasiuk M, Piórkowska G, Kuropka A, Skorupiński P, Charzyńska M, Pluta A, Bomba M, Stremińska W, Jańczyk-Ilach K, Rodziewicz-Motowidło S, Ciemerych MA, Brzoska E, Archacka K.   +19 more
europepmc   +1 more source

Redefining CHI3L1: Therapeutic Opportunities at the Crossroads of Immune Suppression and Disease Progression

Medicinal Research Reviews, EarlyView.
ABSTRACT Chitinase‐3‐like‐1 (CHI3L1, also known as YKL‐40) has been recognized as a biomarker of inflammation and tissue remodeling and has now emerged as a pseudoenzymatic immune checkpoint. Recent structural, immunological, and translational studies redefine it as an active regulator of immune suppression rather than a passive disease marker. Despite
Kirti Upmanyu, Saurabh Upadhyay, Moustafa T. Gabr   +2 more
wiley   +1 more source

Focused ultrasound-mediated blood-brain barrier modulation is associated with adult hippocampal neurogenic responses linked to zinc-dependent signaling. [PDF]

Theranostics
Choi BY, Shin J, Kong C, Park MK, Hong DK, Chung YS, Suh SW, Chang WS.   +7 more
europepmc   +1 more source

Navigating the Complexity: A Comprehensive Review of GSK‐3 Inhibition in Regenerative Medicine

Medicinal Research Reviews, EarlyView.
ABSTRACT Glycogen synthase kinase‐3 (GSK‐3) is a central regulator of numerous cellular signaling pathways, with critical roles in metabolism, proliferation, differentiation, and tissue regeneration. This review explores the multifaceted effects of pharmacological GSK‐3 inhibition across multiple body districts, focusing on its highly context‐dependent
Davide Schiroli, Alessia Merra, Chiara Marraccini, Lucia Merolle, Graziella Pellegrini, Eleonora Maurizi   +5 more
wiley   +1 more source

Humanised Environmental Enrichment: Spatial Effects of Cities and Buildings on Adult Hippocampal Neurogenesis in Humans. [PDF]

Int J Mol Sci
Khalil MH.
europepmc   +1 more source