Results 191 to 200 of about 155,428 (262)

Psychedelics, entactogens and psychoplastogens for depression and related disorders

British Journal of Pharmacology, EarlyView.
Currently, the most actively investigated rapidly acting antidepressants, anxiolytics and/or anti PTSD agents, include psychedelics e.g. psilocybin, LSD, N,N‐dimethyltryptamine, ayahuasca; non‐hallucinogenic entactogens, e.g. MDMA; psychoplastogens which rapidly promote neuroplasticity, e.g.
Daniel Hoyer
wiley   +1 more source

The microcephaly protein Abnormal Spindle has an essential role in symmetrically dividing neural precursors to promote brain growth and development. [PDF]

Dev Biol
Chakraborty S, Florez S, Govaerts J, Hawke A, Schoborg T.   +4 more
europepmc   +1 more source

Cancer pain: current practice and emerging targets

British Journal of Pharmacology, EarlyView.
Cancer pain (CP) arises from a complex interplay between the tumour and its microenvironment. Many patients experience a mixed pain phenotype that encompasses nociceptive, neuropathic and neuroinflammatory mechanisms, and vary across tumour type and disease stage. Despite decades of intensive research, the mainstay of cancer pain treatment is still non‐
Yi Ye, Marcin Chwistek, Zhiting Gong, Vanessa Uzonwanne, Xiaojie Shi, Arpad Szallasi   +5 more
wiley   +1 more source

Molecular signatures and lineage diversification of neurogenic and gliogenic radial glia in the gyrencephalic ferret cortex. [PDF]

Commun Biol
Li J, Yang F, Li W, Fu T, Li Z, Sha Z, Zheng W, Yang C, Yu J, Han D, Jiang X, You Y, Li X, Ma T, He M, Xu Z, Song X, Chen B, Ding J, Wang X, Zhang Z, Yang Z.   +21 more
europepmc   +1 more source

In rats, neurodevelopmental disorders induced by maternal hypoxia are associated with attenuated excitatory neurotransmission in the cingulate cortex

British Journal of Pharmacology, EarlyView.
Background and Purpose Maternal hypoxia is a recognised risk factor for neurodevelopmental disorders in offspring. Although rodent models of hypoxia have been reported, the detailed pathogenesis of maternal hypoxia‐induced neurodevelopmental disorders remains unclear.
Kentaro Tokudome, Masaaki Ueki, Takujiro Homma, Shinji Matsunaga, Saki Shimizu, Yukihiro Ohno, Shuhei Tomita   +6 more
wiley   +1 more source

Irisin as an Exerkine of Neuroprotection in Aging and Alzheimer's Disease. [PDF]

Biomolecules
White ZJ, Hall SE.
europepmc   +1 more source

Priming with interleukin‐1α and chemical hypoxia modulates the mesenchymal stem cell secretome to dampen microglial inflammation and promote neuroprotection

British Journal of Pharmacology, EarlyView.
Abstract Background and Purpose We hypothesised that dual priming of human bone marrow‐derived human mesenchymal stem cells (hBMSCs) with interleukin‐1alpha (IL‐1α) and CoCl2 (a hypoxia mimetic) would modulate their therapeutic efficacy for hypoxic‐ischaemic conditions. Experimental Approach hBMSCs were primed individually or in combination.
Maryam Adenike Salaudeen, Stuart M. Allan, Emmanuel Pinteaux   +2 more
wiley   +1 more source

Mixed Signals and Interspecies Variation in the Plasticity of Adult Mammal Brains. [PDF]

Cells
Pattaro A, Ghibaudi M, Zanone A, Cerrato V, Sherwood CC, Bonfanti L.   +5 more
europepmc   +1 more source

Correction for Lim et al., Longitudinal transformation of mitochondrial metabolism during neurogenesis. [PDF]

Proc Natl Acad Sci U S A
europepmc   +1 more source

Independent control of neurogenesis and dorsoventral patterning by NKX2-2. [PDF]

Genes Dev
Jang S, Abarinov EV, Dobkin JA, Hurley EC, Closser M, Sussel L, Wichterle H.   +6 more
europepmc   +1 more source