Results 71 to 80 of about 22,201 (325)

Multimodal Autonomic Biomarkers Predict Phenoconversion in Pure Autonomic Failure

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Background Pure autonomic failure (PAF) presents with autonomic failure without other neurological features. A third develop central neurological features, fulfilling criteria for multiple system atrophy (MSA) and Lewy body diseases (LBD), including Parkinson's disease and Dementia with Lewy bodies.
S. Koay, E. Vichayanrat, F. Bremner, F. Valerio, R. Mackenzie, G. Chiaro, G. Ingle, P. McNamara, L. Watson, J. N. Panicker, M. P. Lunn, C. Mathias, V. Iodice   +12 more
wiley   +1 more source

Microglial Dyshomeostasis: A Common Substrate in Neurodevelopmental and Neurodegenerative Diseases

Neuroglia
Neurodevelopmental disorders such as autism spectrum disorder (ASD) and attention-deficit hyperactivity disorder (ADHD) are clinically distinct, yet share synaptic dysfunction as a common brain pathophysiology.
Vada Andree Furlan, Daria MacAuslan, Khiem Ha, Nitish Patel, Shawn Adam, Beylem Zanagar, Sharmila Venugopal   +6 more
doaj   +1 more source

Neurotoxicity [PDF]

, 2014
Neurotoxicity refers to the direct or indirect effect of chemicals that disrupt the nervous system of humans or animals. Numerous chemicals can produce neurotoxic diseases in humans, and many more are used as experimental tools to disturb or damage the ...
Brust, Creeley, Feldman, Grandjean, Herken, Panzica, Parent, Pessah, Rice, Román, Spencer, Spencer, Tu, Vinken, Yasui, Zawia   +15 more
core   +2 more sources

Cognitive Resilience in Apolipoprotein ε4 Carrier Women Predicted by Neuron‐Derived Extracellular Vesicles

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective The Apolipoprotein (APOE) ε4 allele is the strongest genetic risk factor for late‐onset Alzheimer's disease (AD); however, many ε4 carriers remain cognitively intact into old age. Leveraging plasma neuron‐derived extracellular vesicles (NDEVs), we sought to identify biomarkers of cognitive resilience and their interplay with APOE ...
Apostolos Manolopoulos, Maja Mustapic, Carlos Nogueras‐Ortiz, Francheska Delgado‐Peraza, Krishna A. Pucha, Pamela J. Yao, Joseph Blommer, Michael P. Vreones, William York, De' Larrian Knight, Stephen R. Rapp, Aladdin H. Shadyab, JoAnn E. Manson, Ramon Casanova, Robert B. Wallace, Luigi Ferrucci, Susan M. Resnick, Dimitrios Kapogiannis   +17 more
wiley   +1 more source

Exploring glia to better understand Alzheimer’s disease

Animal Cells and Systems, 2018
The amyloid-β (Aβ) hypothesis has been the leading explanation for the pathogenesis of Alzheimer’s disease (AD). The most common traits of AD are cognitive impairments and memory loss, which are associated with the accumulation of Aβ.
Yoo Sung Kim, Hae Myeong Jung, Bo-Eun Yoon   +2 more
doaj   +1 more source

Density-dependence of functional development in spiking cortical networks grown in vitro

, 2008
During development, the mammalian brain differentiates into specialized regions with distinct functional abilities. While many factors contribute to functional specialization, we explore the effect of neuronal density on the development of neuronal ...
A Tang, B Anderson, Cara L. Santa Maria, DA Wagenaar, E Maeda, E Schneidman, F Rieke, G Bi, G Shahaf, G Spitsyna, H Markram, JH Kim, JM Beggs, JP Pfister, K Nakanishi, L Paninski, LMA Bettencourt, LMA Bettencourt, Luìs M. A. Bettencourt, M Abeles, M Diesmann, MA Corner, Marko A. Rodriguez, MI Ham, Michael I. Ham, O Feinerman, RM Herndon, Ryan A. Bennett, S Marom, TM Cover, Vadas Gintautas, Y Jimbo   +31 more
core   +1 more source

The rs10191329 Risk Allele Is Associated With Pronounced Retinal Layer Atrophy in Multiple Sclerosis

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective To investigate whether the rs10191329 risk allele in the DYSF–ZNF638 locus, which is implicated in central nervous system resilience rather than immune‐mediated pathology, is associated with retinal layer thinning, a biomarker of neuroaxonal damage in relapsing multiple sclerosis (RMS). Methods From a prospective observational study,
Gabriel Bsteh, Ruchi Tanavade, Nik Krajnc, Fabian Föttinger, Theresa König, Martin Krenn, Lukas Haider, Barbara Kornek, Fritz Leutmezer, Kerstin U. Ludwig, Stefan Macher, Tobias Monschein, Markus Ponleitner, Paulus Rommer, Christiane Schmied, Karin Zebenholzer, Tobias Zrzavy, Gudrun Zulehner, Franziska Di Pauli, Axel Schmidt, Harald Hegen, Berthold Pemp, Thomas Berger   +22 more
wiley   +1 more source

PENGARUH PEMBERIAN EKSTRAK METANOL BUNGA FLAMBOYAN (DELONIX REGIA (BOJER EX HOOK.) RAF.) TERHADAP HISTOPATOLOGI CEREBRUM TIKUS (RATTUS NOVERGICUS) DIABETES SETELAH DIINDUKSI ALOKSAN [PDF]

, 2018
ABSTRAKDiabetes melitus merupakan keadaan hiperglikemia kronik yang dapat mengakibatkan kerusakan sel neuron dan neuroglia pada cerebrum otak. Penelitian ini bertujuan untuk mengetahui pengaruh pemberian ekstrak metanol bunga flamboyan (Delonix regia ...
Yudi Gebri Foenna
core  

The Potential for Extracellular Vesicles in Nanomedicine: A Review of Recent Advancements and Challenges Ahead

Advanced Biology, EarlyView.
Extracellular vesicles (EVs) play a dual role in diagnostics and therapeutics, offering innovative solutions for treating cancer, cardiovascular, neurodegenerative, and orthopedic diseases. This review highlights EVs’ potential to revolutionize personalized medicine through specific applications in disease detection and treatment.
Farbod Ebrahimi, Anjali Kumari, Samaneh Ghadami, Saqer Al Abdullah, Kristen Dellinger   +4 more
wiley   +1 more source

Book Review: Microscopic anatomy of invertebrates [PDF]

, 1998
Book Review: Microscopic anatomy of invertebrates, VoL 11, A, B, C, Insecta. Harrison, Frederick W. (editor), and Michael Locke. New York: Wiley-Liss, voL 11A, xxii+381 [+index 1-74], voL 11B, xxii+385-840 [+index 1-74 (repeated)], voL 3, xxii+843-1296 [
Arnett, Ross H. Jr.
core